Results 81 to 90 of about 7,386,473 (331)

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Designing an educational software of mathematics for elementary school students from the point of view of constructivism and its effectiveness [PDF]

فصلنامه نوآوری‌های آموزشی, 2004
This investigation studies the view of constructivism computer-based education. The purpose of this study was to produce mathematics educational software based on constructivism and studies its effectiveness with two randomly chosen groups of subjects ...
Mostafa Sheykhzadeh, Mahmood Mehrmohammadi   +1 more
doaj  

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Aspects of (2+1) dimensional gravity: AdS3 asymptotic dynamics in the framework of Fefferman-Graham-Lee theorems [PDF]

, 1999
Using the Chern-Simon formulation of (2+1) gravity, we derive, for the general asymptotic metrics given by the Fefferman-Graham-Lee theorems, the emergence of the Liouville mode associated to the boundary degrees of freedom of (2+1) dimensional anti de ...
Rooman, M., Spindel, Ph.
core   +1 more source

A continuous low star formation rate in IZw 18 ?

, 2000
Deep long-slit spectroscopic observations of the blue compact galaxy IZw 18 obtained with the CFH 3.6 m Telescope are presented. The very low value of oxygen abundance previously reported is confirmed and a very homogeneous abundance distribution is ...
Kunth, D., Legrand, F., Mas-Hesse, J. M., Roy, J. -R., Walsh, J. R.   +4 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Caracterización de aleaciones de magnesio mediante microscopía de fuerza atómica con sonda Kelvin de barrido (SKPFM)

Iteckne, 2011
Dos aleaciones de magnesio ZE41 y AZ91D, producidas comercialmente, fueron estudiadas mediante microscopía de fuerza atómica con sonda Kelvin de barrido (SKPFM, siglas en inglés) con el fin de evaluar el papel de sus fases microconstituyentes en ...
Ana Emilse Coy-Echeverría, Fernando Viejo Abrante, Sandra Judith García Vergara, George Thompson, Peter Skeldon, Am Hich   +5 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Education and continuing professional development of physical education teachers – structures, challenges and current research tendencies

Schweizerische Zeitschrift für Bildungswissenschaften, 2023
Christelle Hayoz, Ilaria Ferrari, Matthias Baumgartner   +2 more
doaj   +1 more source