Results 91 to 100 of about 469,268 (356)

Modeling the architecture of depolymerase-containing receptor binding proteins in Klebsiella phages [PDF]

open access: yes, 2019
Klebsiella pneumoniae carries a thick polysaccharide capsule. This highly variable chemical structure plays an important role in its virulence. Many Klebsiella bacteriophages recognize this capsule with a receptor binding protein (RBP) that contains a ...
Briers, Yves   +3 more
core   +2 more sources

Highly Resolved Community Sewage Metagenomics Unveiling Landscape and Transmission Patterns of Antibiotic Resistome in Hong Kong Populations

open access: yesAdvanced Science, EarlyView.
A large‐scale, high‐resolution antimicrobial resistance (AMR) surveillance in Hong Kong community sewage combining short‐ and long‐read sequencing. The resistome profile is comprehensively characterized, and this upstream sampling strategy demonstrated superiority in reflecting the human gut resistome.
Jiahui Ding   +11 more
wiley   +1 more source

Molecular characterization of Salmonella Enteritidis : comparison of an optimized multi-locus variable-number of tandem repeat analysis (MLVA) and pulsed-field gel electrophoresis [PDF]

open access: yes, 2012
Salmonella Enteritidis (SE) is a genetically homogenous serovar, which makes optimal subtype discrimination crucial for epidemiological research. This study describes the development and evaluation of an optimized multiple-locus variable number tandem ...
Bertrand, Sophie   +9 more
core   +2 more sources

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

open access: yesAdvanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun   +23 more
wiley   +1 more source

Network Models of Phage-Bacteria Coevolution [PDF]

open access: yes, 2006
Bacteria and their bacteriophages are the most abundant, widespread and diverse groups of biological entities on the planet. In an attempt to understand how the interactions between bacteria, virulent phages and temperate phages might affect the ...
Dodd, Ian B.   +3 more
core   +2 more sources

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

open access: yesAdvanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong   +6 more
wiley   +1 more source

Teaching Trigonometry in Alfred Nzo West Education District: Educator Perspective and Challenges

open access: yesAraştırma Temelli Etkinlik Dergisi
This qualitative case study investigates challenges faced by educators teaching trigonometry in Grade 12 within the Alfred Nzo West Education District, where persistent underperformance is linked to socio-economic and resource limitations.
Kereditse Gladys Chake   +2 more
doaj  

Mutual exclusion between related phages [PDF]

open access: yes, 1952
The discovery of the breakdown of superinfecting phage needs to be supplemented by genetic tests to find out whether the phage whose nucleic acid is broken down is, indeed, unable to contribute genetic markers to the progeny.
Dulbecco, R.
core   +1 more source

Author response for "A rapid novel strategy for screening of antibody phage libraries for production, purification, and functional characterization of amber stop codons containing single‐chain antibody fragments ( scFvs )"

open access: gold, 2021
Reshma Perween   +10 more
openalex   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

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