Results 111 to 120 of about 359,710 (297)

Personalized Phage Therapy in an ICU Patient with Polymicrobial Pulmonary Infections: a case from a single-arm trial

Nature Communications
Ventilator-associated infections (VAIs) caused by multidrug-resistant (MDR) pathogens poses a significant challenge in intensive care units (ICUs). Phage therapy has emerged as a promising alternative for VAIs, though its efficacy depends on multiple ...
Yongxin Shi, Jie Li, Qian Yang, Jianhui Li, Linlin Li, Jianfang Liu, Jia Dai, Yumeng Shang, Xin Zhou, Lan Yang, Chuanjiang Chen, Ziqi Zhao, Huiqin Zhang, Juan Bao, Tongyu Zhu, Mengjun Cheng, Nannan Wu, He Wang   +17 more
doaj   +1 more source

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

Advanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu, Wanlin Chen, Ben Cristofori‐Armstrong, Theo Crawford, Kai‐En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt, Jennifer D. Naughton, Nicholas D. Condon, Åsa Andersson, Farhad Dehkhoda, Kirsten L. McMahon, Tabea Klasfauseweh, Ashvriya Thapa, Hue Tran, Poanna Tran, Sina Jami, Lotten Ragnarsson, Sebastian G. B. Furness, Jennifer R. Deuis, Brett M. Collins, Wai‐Hong Tham, Indira Prasadam, Irina Vetter, Mehdi Mobli   +27 more
wiley   +1 more source

Correction: Morphological, biological, and genomic characterization of Klebsiella pneumoniae phage vB_Kpn_ZC2

Virology Journal, 2023
Mohamed S. Fayez, Toka A. Hakim, Bishoy Maher Zaki, Salsabil Makky, Mohamed Abdelmoteleb, Kareem Essam, Anan Safwat, Abdallah S. Abdelsattar, Ayman El-Shibiny   +8 more
doaj   +1 more source

Efficacy of phage vB_EcoP_ZCEC16 in controlling Escherichia coli contamination in fresh poultry meat

BMC Microbiology
Avian pathogenic Escherichia coli (APEC) poses a substantial economic and health challenges for poultry and meat industries. One of the promising alternative approaches to overcome bacterial contamination in food products is bacteriophage, due to its ...
Azza G. Kamel, Zainab K. Hammouda, Sohaila Tarek, Yousef Nassar, Eman E. Elawsya, Ahmed Osama, Bishoy Maher Zaki, Mohammad Gharaibeh, Rashad Al-Hindi, Ihab Habib, Ayman El-Shibiny   +10 more
doaj   +1 more source

METAGENOMIC STUDY TOWARDS PHAGE THERAPY INPROVEMENT: WHAT DO WE LEARN FROM BALANCE AND BACTERIA / PHAGE RATIO? [PDF]

Phage therapy can be most simply understood as an alternative to antibiotics, especially in the context of bacterial infections that have developed resistance to conventional treatments.
Cristina Giaroni, Gustavo Di Lallo, David Brandtner, Pietro D’Addabbo, Roberto Malinverni, Walter Sanseverino, Giuseppina La Rosa, FREZZA Domenico, Andreina Baj, Annalisa Bosi, Pamela Mancini, Rossella Cianci., Marcello Iaconelli   +12 more
core  

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Characterization of a new lytic bacteriophage vB_RanS_GDF21 and its endolysin LysGDF21 with antimicrobial activity against Riemerella anatipestifer

Frontiers in Microbiology
IntroductionRiemerella anatipestifer (R. anatipestifer) presents as a major pathogen causing septicemia among poultry. The complex serotype diversity and multidrug resistance of R.
Yaru Zhao, Yaru Zhao, Yulan Liu, Yulan Liu, Yina Jiang, Yina Jiang, Xiaoting Li, Xiaoting Li, Zhenshu Si, Zhenshu Si, Jianbiao Lu, Jianbiao Lu, Shengliang Cao, Shengliang Cao, Xijuan Xue, Yubao Li, Yubao Li, Cheng Liu, Cheng Liu   +18 more
doaj   +1 more source