Results 121 to 130 of about 327,788 (316)

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy, Darby Alistair C, Alistair C Darby, Allison Heather E, Rooks David J, Rooks, David, Smith, Darren, Paul CM Fogg, Thomson, Nicholas, David J Rooks, Smith Darren L, McCarthy Alan J, McCarthy, Alan, Heather E Allison, Darren L Smith, Allison, Heather, Fogg Paul CM, Nick R Thomson, Fogg, Paul, Darby, Alistair, Thomson Nick R   +20 more
core   +1 more source

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Correction: Morphological, biological, and genomic characterization of Klebsiella pneumoniae phage vB_Kpn_ZC2

Virology Journal, 2023
Mohamed S. Fayez, Toka A. Hakim, Bishoy Maher Zaki, Salsabil Makky, Mohamed Abdelmoteleb, Kareem Essam, Anan Safwat, Abdallah S. Abdelsattar, Ayman El-Shibiny   +8 more
doaj   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Phage vB_Ec_ZCEC14 to treat antibiotic-resistant Escherichia coli isolated from urinary tract infections

Virology Journal
Escherichia coli is a commensal bacterial species in the human gastrointestinal tract; however, it could be pathogenic and cause severe infections in intra and extra-intestinal sites. Uropathogenic E.
Nedaa M. Ismael, Mohamed Azzam, Mohamed Abdelmoteleb, Ayman El-Shibiny   +3 more
doaj   +1 more source

Characterization of a new lytic bacteriophage vB_RanS_GDF21 and its endolysin LysGDF21 with antimicrobial activity against Riemerella anatipestifer

Frontiers in Microbiology
IntroductionRiemerella anatipestifer (R. anatipestifer) presents as a major pathogen causing septicemia among poultry. The complex serotype diversity and multidrug resistance of R.
Yaru Zhao, Yaru Zhao, Yulan Liu, Yulan Liu, Yina Jiang, Yina Jiang, Xiaoting Li, Xiaoting Li, Zhenshu Si, Zhenshu Si, Jianbiao Lu, Jianbiao Lu, Shengliang Cao, Shengliang Cao, Xijuan Xue, Yubao Li, Yubao Li, Cheng Liu, Cheng Liu   +18 more
doaj   +1 more source

Between Centralization and Fragmentation: The Past, Present, and Future of Phage Collections [PDF]

International audienceDespite over a century of collecting bacteriophages, there has been a persistent lack of interest in systematically cataloging resulting phage banks.
Resch, Grégory, Kirchhelle, Claas, Laurent, Frédéric, Moineau, Sylvain, Hodges, Francesca, Rohde, Christine, Debarbieux, Laurent, Brives, Charlotte, Martins, Ana Filipa Moreira   +8 more
core   +1 more source

Gephyrin Neurological Autoimmunity

Annals of Neurology, EarlyView.
Gephyrin is a postsynaptic scaffold protein essential for inhibitory neurotransmission. Gephyrin‐immunoglobulin G (IgG) was reported, decades ago, in a single case of paraneoplastic stiff‐person‐like syndrome, but its broader clinical relevance remains unknown.
Maria Chiara Pantuliano, Friederike A. Arlt, Naomi Arenson, Irena Dujmovic Basuroski, Divyanshu Dubey, Connie E. Lesnick, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael A. Lane, Andrew McKeon   +10 more
wiley   +1 more source

Efficacy of systemic temozolomide‐activated phage‐targeted gene therapy in human glioblastoma

EMBO Molecular Medicine, 2019
Glioblastoma multiforme (GBM) is the most lethal primary intracranial malignant neoplasm in adults and most resistant to treatment. Integration of gene therapy and chemotherapy, chemovirotherapy, has the potential to improve treatment. We have introduced
Justyna Magdalena Przystal, Sajee Waramit, Md Zahidul Islam Pranjol, Wenqing Yan, Grace Chu, Aitthiphon Chongchai, Gargi Samarth, Nagore Gene Olaciregui, Ghazaleh Tabatabai, Angel Montero Carcaboso, Eric Ofori Aboagye, Keittisak Suwan, Amin Hajitou   +12 more
doaj   +1 more source

Structural and Biochemical Characterization of a New Phage-Encoded Muramidase, KTN6 Gp46 [PDF]

Endolysins are phage-encoded lytic enzymes that degrade bacterial peptidoglycan at the end of phage lytic cycles to release new phage particles.
van Ryne, Michael, van Ryne, M., De Maesschalck, Vincent, Drulis-Kawa, Zuzanna, Danis-Wlodarczyk, K., De Maesschalck, V., Drulis-Kawa, Z., Sanz-Gaitero, Marta, Rodriguez-Rubio, Lorena, Van Noort, Vera, Van Noort, V., van Raaij, Mark, Patel, A., Mesnage, Stephane, Sanz-Gaitero, M., van Raaij, M., Lavigne, Rob, Longin, H., Danis-Wlodarczyk, Katarzyna, Patel, Ankur, Longin, Hannelore, Lavigne, R., Rodriguez-Rubio, L., Mesnage, S.   +23 more
core   +1 more source