Results 131 to 140 of about 359,710 (297)

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University

Scientific Reports
Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked the centennial of Felix d’Hérelle’s first publication on the clinical applications of phages.
Silvia Würstle, Alina Lee, Kaitlyn E. Kortright, Franziska Winzig, William An, Gail L. Stanley, Govindarajan Rajagopalan, Zach Harris, Ying Sun, Buqu Hu, Michael Blazanin, Maryam Hajfathalian, Paul L. Bollyky, Paul E. Turner, Jonathan L. Koff, Benjamin K. Chan   +15 more
doaj   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

In Vitro Selection of Functional Neoproteins Containing Highly Fluorinated Cores

Angewandte Chemie, EarlyView.
The generation of neoproteins—functional proteins containing unnatural amino acids—is a key goal in synthetic biology. We develop a platform to discover neoproteins with specified bioactivity from trillion‐member sequence libraries, using genetic code reprogramming, in vitro selection and microwave peptide synthesis.
Adam Beattie, Alexander Vinogradov, Chikako Okada, Toru Sengoku, Takayuki Katoh, Hiroaki Suga   +5 more
wiley   +2 more sources

Quantifying Structure‐Dependent Rigidity of 3D DNA Origami Boxes

Advanced Intelligent Systems, EarlyView.
We investigate the mechanical stability of a hollow 3D DNA origami box during assembly using liquid AFM imaging and finite element simulations. As structural completeness increases from flat sheets through intermediate assemblies to a closed box, rigidity improves.
Judith Zubia‐Aranburu, Reza Zadegan, Jens Vinge Nygaard, Jørgen Kjems, Ramesh Subramani, Mingdong Dong   +5 more
wiley   +1 more source

Cross‐Sectoral AI Integration Is Essential to Tackling Food Waste and Food Insecurity: A Roadmap for Developing Resilient Food Systems

Advanced Intelligent Systems, EarlyView.
As food insecurity and global food demands surge, artificial intelligence (AI)‐based technologies offer promising opportunities to reduce food loss and waste. In this perspective, current AI adoption across the food supply chain is assessed using various academic, industry, and policy sources.
Akansha Prasad, Hannah Mann, Lubna Najm, Shadman Khan, Carlos D. M. Filipe, Tohid F. Didar   +5 more
wiley   +1 more source

Addressing the Research and Development Gaps in Modern Phage Therapy [PDF]

Antimicrobial resistance is on the rise globally, prompting increased research and development (R&D) of phage therapy as a strategy to address difficult-to-treat bacterial infections. We review the current state of phage therapy research, including major
Turner, Paul, Moreno, Mercedes Gonzalez, Azeredo, Joana, Haaber, Jakob Krause, Portillo, Mirza Alas, Green, Sabrina, Kameda de Figueiredo Carvalho, Koichi, Haggstrom, Douglas, Kirchhelle, Claas, Carvalho, Koichi Kameda de Figueiredo, Pirnay, Jean-Paul, Gonzalez Moreno, Mercedes, Buurman, Ed. T., Buurman, Ed, Turner, Paul E., Kameda, Koichi, Buurman, Ed T.   +16 more
core   +1 more source

MATURATION OF PHAGE AND THE EVIDENCE OF PHAGE PRECURSORS

Cold Spring Harbor Symposia on Quantitative Biology, 1953
C, LEVINTHAL, H W, FISHER
openaire   +2 more sources