Results 91 to 100 of about 171,183 (250)

PhREEPred: Phage Resistance Emergence Prediction Web Tool to Foresee Encapsulated Bacterial Escape from Phage Cocktail Treatment

Journal of Molecular Biology, 2022
Phages, as well as phage-derived proteins, especially lysins and depolymerases, are intensively studied to become prospective alternatives or supportive antibacterials used alone or in combination. In the common phage therapy approach, the unwanted emergence of phage-resistant variants from the treated bacterial population can be postponed or reduced ...
Smug, Bogna, Majkowska-Skrobek, Grazyna, Drulis-Kawa, Zuzanna   +2 more
openaire   +3 more sources

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Phage-based biocontrol of Salmonella and E. coli in raw chicken filets: optimizing phage-based solutions to enhance food safety under cooled storing conditions

Frontiers in Microbiology
Food safety continues to be an important issue for consumer protection and public health globally. Chicken meat is considered a primary source of Salmonella and E. coli infections in humans. In recent years, phage-based biocontrol has attracted attention
Oleksandra Berhilevych, Elisa Peh, Johanna Charlotte Vahle, Madeleine Plötz, Sophie Kittler   +4 more
doaj   +1 more source

Anti-phage islands force their target phage to directly mediate island excision and spread. [PDF]

, 2018
Vibrio cholerae, the causative agent of the diarrheal disease cholera, is antagonized by the lytic phage ICP1 in the aquatic environment and in human hosts. Mobile genetic elements called PLEs (phage-inducible chromosomal island-like elements) protect V.
McKitterick, Amelia C, Seed, Kimberley D
core   +1 more source

Phage cocktail SalmoFREE® reduces Salmonella on a commercial broiler farm

Poultry Science, 2019
According to the World Health Organization, Salmonella is one of the most important zoonotic foodborne pathogens. Poultry products are thought to be the main source of Salmonella, which means that it is necessary to control Salmonella at the pre-harvest stage.
V Clavijo, D Baquero, S Hernandez, J.C. Farfan, J Arias, A Arévalo, P Donado-Godoy, M Vives-Flores   +7 more
openaire   +2 more sources

A mechanism-based pathway toward administering highly active N-phage cocktails

Frontiers in Microbiology, 2023
Bacteriophage (phage) therapy is being explored as a possible response to the antimicrobial resistance public health emergency. Administering a mixture of different phage types as a cocktail is one proposed strategy for therapeutic applications, but the optimal method for formulating phage cocktails remains a major challenge.
Nicholas M. Smith, Thomas D. Nguyen, Wai Hoe Chin, Jacob T. Sanborn, Harriet de Souza, Brian M. Ho, Tiffany Luong, Dwayne R. Roach   +7 more
openaire   +3 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Estimation of the In-Vitro Synergistic Effect of Vancomycin with Bacteriophage and its Endolysin on Iraqi Local Isolates of Enterococcus faecalis

مجلة بغداد للعلوم
Enterococcus faecalis is known to cause many serious infections with an upsurge in the development of antibiotic resistant strains, especially vancomycin.
Rand R. Hafidh, Zainab Oday Hamed, Abdullah A. Awni, Manal N. Jassas   +3 more
doaj   +1 more source

A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons. [PDF]

, 2019
Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make them uniquely suited for certain biomedical research, diagnostic and therapeutic applications.
Dong, Jie-Xian, Dumitras, Camelia, Gong, Belvin, Kirmiz, Michael, Lee, Yongam, Moreno, Claudia M, Murray, Karl D, Palacio, Stephanie, Sando, Richard, Santana, L Fernando, Südhof, Thomas C, Trimmer, James S   +11 more
core  

Bacteriophages and their role in food safety [PDF]

, 2012
The interest for natural antimicrobial compounds has increased due to alterations in consumer positions towards the use of chemical preservatives in foodstuff and food processing surfaces.
Azeredo, Joana, Oliveira, Hugo Alexandre Mendes, Sillankorva, Sanna   +2 more
core   +3 more sources