Results 81 to 90 of about 17,973 (167)
Cell Proliferation, EarlyView.Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
Three New Escherichia coli Phages from the Human Gut Show Promising Potential for Phage Therapy. [PDF]
PLoS ONE, 2016 With the emergence of multi-drug resistant bacteria the use of bacteriophages (phages) is gaining renewed interest as promising anti-microbial agents. The aim of this study was to isolate and characterize phages from human fecal samples.
Marion Dalmasso +6 more
doaj +1 more source
Transgenic selection and underlying mechanisms in apicomplexan parasites
The FEBS Journal, EarlyView.Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
wiley +1 more source
The FEBS Journal, EarlyView.Bacteriophages—viruses that kill bacteria—are promising weapons against bacterial biofilms: sessile communities notoriously resistant to antibiotics. Yet phages evolved not so much to eradicate bacteria as to obtain new bacteria to infect. That goal, however, may conflict with the physician's objective of complete bacterial clearance.
Stephen T. Abedon
wiley +1 more source
Virus Research, 2016 The aim of this study was to compare the dynamics of three previously isolated bacteriophages (or phages) individually (phSE-1, phSE-2 and phSE-5) or combined in cocktails of two or three phages (phSE-1/phSE-2, phSE-1/phSE-5, phSE-2/phSE-5 and phSE-1/phSE-2/phSE-5) to control Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) in order to ...
Carla, Pereira +9 more
openaire +2 more sources
Computational Basis for On-Demand Production of Diversified Therapeutic Phage Cocktails
mSystems, 2020 The antibiotic resistance crisis has led to renewed interest in phage therapy as an alternative means of treating infection. However, conventional methods for isolating pathogen-specific phage are slow, labor-intensive, and frequently unsuccessful. We have demonstrated that computationally identified prophages carried by near-neighbor bacteria can ...
Catherine M. Mageeney +8 more
openaire +5 more sources
Novel and emerging antimicrobial strategies in the management of oral infections
Periodontology 2000, EarlyView.Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley +1 more source
Correction to: multireceptor phage cocktail against Salmonella enterica to circumvent phage resistance. [PDF]
Microlifeeuropepmc +2 more sources
Advances in large DNA fragment assembly for microbial cell factory engineering
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang +5 more
wiley +1 more source
Virus Research, 2019 The control and treatment of multidrug resistant pathogens infections has become a grand challenge for clinicians worldwide. Virulent phage has long been considered as an effective bactericidal agent, which may be a potentially alternative to antibiotics.
Yuyu, Yuan +5 more
openaire +2 more sources