Results 61 to 70 of about 17,973 (167)

Phage-based biocontrol of Salmonella and E. coli in raw chicken filets: optimizing phage-based solutions to enhance food safety under cooled storing conditions

Frontiers in Microbiology
Food safety continues to be an important issue for consumer protection and public health globally. Chicken meat is considered a primary source of Salmonella and E. coli infections in humans. In recent years, phage-based biocontrol has attracted attention
Oleksandra Berhilevych, Elisa Peh, Johanna Charlotte Vahle, Madeleine Plötz, Sophie Kittler   +4 more
doaj   +1 more source

Development and Evaluation of Bacteriophage Cocktail to Eradicate Biofilms Formed by an Extensively Drug-Resistant (XDR) Pseudomonas aeruginosa

Viruses, 2023
Extensive and multiple drug resistance in P. aeruginosa combined with the formation of biofilms is responsible for its high persistence in nosocomial infections.
Medhavi Vashisth, Anu Bala Jaglan, Shikha Yashveer, Priya Sharma, Priyanka Bardajatya, Nitin Virmani, Bidhan Chand Bera, Rajesh Kumar Vaid, Taruna Anand   +8 more
doaj   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Estimation of the In-Vitro Synergistic Effect of Vancomycin with Bacteriophage and its Endolysin on Iraqi Local Isolates of Enterococcus faecalis

مجلة بغداد للعلوم
Enterococcus faecalis is known to cause many serious infections with an upsurge in the development of antibiotic resistant strains, especially vancomycin.
Rand R. Hafidh, Zainab Oday Hamed, Abdullah A. Awni, Manal N. Jassas   +3 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Phage treatment significantly reduces Salmonella shedding in layer hens and Salmonella abundance on the surface of the eggs they produce

Poultry Science
Non-typhoidal Salmonella species cause 85% of human foodborne cases and infections caused by multidrug-resistant Salmonella strains are increasing. Therefore, alternative antimicrobials are needed, and phage therapy offers a promising tool to reduce the ...
Anisha M. Thanki, Natasha Whenham, Tom Dale, Mike R. Bedford, Helen V. Masey O’Neill, Martha R.J. Clokie   +5 more
doaj   +1 more source

Oral Administration of a Phage Cocktail to Reduce Salmonella Colonization in Broiler Gastrointestinal Tract—A Pilot Study

Animals, 2022
Salmonella contamination in poultry meat products can lead to serious foodborne illness and economic loss from product recalls. It is crucial to control Salmonella contamination in poultry from farm to fork.
Wattana Pelyuntha, Ananya Yafa, Ruttayaporn Ngasaman, Mingkwan Yingkajorn, Kridda Chukiatsiri, Nidanut Champoochana, Kitiya Vongkamjan   +6 more
doaj   +1 more source

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

Interdisciplinary Medicine, EarlyView.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma, Jiahui Huang, Yitong Chen, Haoxuan Wang, Hang Zou, Wanghong Zhao, Zilong Deng   +6 more
wiley   +1 more source

The toxin–antitoxin complex Fic‐1–AntF functions as a deAMPylase that regulates the activity of DNA gyrase

mLife, EarlyView.
Abstract Toxin–antitoxin (TA) systems found in diverse bacteria play important roles in their adaptation to changing environments. The toxin of the Fic‐1–AntF TA pair from Pseudomonas bijieensis strain 2P24 inhibits bacterial DNA replication by attacking the subunit B of DNA gyrase (GyrB) via AMPylation, while the antitoxin AntF blocks its enzymatic ...
Furong Chen, Liwei Guo, Canhua Lu, Wenjun Jiang, Zhao‐Qing Luo, Junfeng Liu, Li‐Qun Zhang   +6 more
wiley   +1 more source

A bacteriophage cocktail can efficiently reduce five important Salmonella serotypes both on chicken skin and stainless steel

Frontiers in Microbiology
Salmonella is one of the most important zoonotic pathogens and is mostly transmitted through food of animal origin. Application of bacteriophages is a promising tool to biocontrol Salmonella on both food and food contact surfaces.
Tamar Gvaladze, Hansjörg Lehnherr, Stefan Hertwig   +2 more
doaj   +1 more source