Results 91 to 100 of about 17,973 (167)

Isolation and Characterization of Specific Phages to Prepare a Cocktail Preventing Vibrio sp. Va-F3 Infections in Shrimp (Litopenaeus vannamei)

Frontiers in Microbiology, 2019
Vibrio is one of the most detrimental agents of shrimp premature death syndrome. Phage therapy for prevention and treatment of Vibrio infections has attracted increasing attentions due to the emergence of antibiotic-resistant bacterial variants. Here, we
Ling Chen, Ling Chen, Ling Chen, Ling Chen, Jiqiang Fan, Jiqiang Fan, Jiqiang Fan, Tingwei Yan, Quan Liu, Shengjian Yuan, Shengjian Yuan, Shengjian Yuan, Shengjian Yuan, Haoran Zhang, Haoran Zhang, Jinfang Yang, Deng Deng, Shuqiang Huang, Shuqiang Huang, Shuqiang Huang, Yingfei Ma, Yingfei Ma, Yingfei Ma, Yingfei Ma   +23 more
doaj   +1 more source

USP43‐mediated deubiquitination of SLC7A11 protects against LPS‐induced acute lung injury by inhibiting ferroptosis

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Ubiquitin‐specific protease 43 (USP43) in up‐regulated during lipopolysaccharide (LPS)‐induced acute lung injury (ALI). USP43 interacts and inhibits the degradation of solute carrier family 7 member 11 (SLC7A11) by removing the K48‐linked ubiquitination of it, thereby suppressing ferroptosis.
Li Zhang, Jutong He, Ming Xu, Bamawa Mwengendi Joël, Guiomar Correia, Xuefeng Zhou, Xinyi Li, Hexiao Tang   +7 more
wiley   +1 more source

Glycolytic metabolism of CD8+ T‐cells affects susceptibility to human leukocyte antigen‐mediated abacavir‐induced hypersensitivity

British Journal of Pharmacology, Volume 183, Issue 13, Page 3743-3761, July 2026.
Abstract Background and Purpose Drug hypersensitivity reactions (DHRs) associated with a specific human leukocyte antigen (HLA) allotype do not manifest uniformly in all individuals within an HLA model population. This scenario highlights the complexity of predicting drug hypersensitivity reaction risk without considering additional factors ...
Takeshi Susukida, Yuchen Sun, Noriaki Arakawa, Takuya Hirao, Tadahaya Mizuno, Shigeki Aoki, Kousei Ito, Yoshihiro Hayakawa   +7 more
wiley   +1 more source

Expanding the Toolbox for Biocatalytic Halogenation by Identification and Characterization of Three Vanadium Chloroperoxidases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Schematic illustration of the workflow from DNA sequence‐based research to expression in shaking flasks and subsequent purification via IMAC. The obtained enzymes broaden the toolbox of enzymes used for halogenation reactions with differing catalytic properties and tolerances to reaction‐related conditions.
Sonja Schönrock, Nils Senge, Dirk Holtmann   +2 more
wiley   +1 more source

Lytic Activity of Various Phage Cocktails on Multidrug-Resistant Bacteria

Clinical and Investigative Medicine, 2016
Purpose A bacteriophage is a virus that infects and replicates within a bacterium following the injection of phage genome into the bacterial cytoplasm. They are seen as a possible therapy for multi-drug-resistant strains of many bacteria. The aim of this study is to evaluate the lytic activity of the Pyo, Intesti and Fersisi bacteriophage cocktails on ...
I, Ozkan, E, Akturk, N, Yeshenkulov, S, Atmaca, N, Rahmanov, H I, Atabay   +5 more
openaire   +3 more sources

Development of a Bacteriophage Cocktail to Evaluate In Vitro and In Vivo Therapeutic Efficacy Against ESBL Producing Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance
INTRODUCTION: Klebsiella pneumoniae as commensal Gram-negative bacilli and a member of ESKAPE pathogens is common cause of bacteremia, endocarditis, wound, respiratory and urinary tract infections.
Sidrah Asghar, Ayaz Ahmed
doaj   +1 more source

SocialViruses: integrating quantitative phage–bacteria and phage–phage interaction networks for rational cocktail design

Bioinformatics Advances
Abstract Motivation Phage therapy is emerging as a promising alternative to antibiotics in biomedical research, highlighting the growing need for computational tools to rationally design effective phage cocktails.
Felipe Molina, Manuel Menor-Flores, Miguel A Vega-Rodríguez   +2 more
openaire   +2 more sources

Rapid resistance evolution against phage cocktails

The ISME Journal
When bacteria are treated with multiple antibiotics simultaneously, resistance is highly unlikely to evolve. In stark contrast, resistance against multiple phages frequently arises during therapy. Why does resistance against multi-phage cocktails evolve so easily?
Baltus A van der Steen, Matti Gralka, Yuval Mulla   +2 more
openaire   +1 more source

A game of resistance: War between bacteria and phages and how phage cocktails can be the solution

Virology
While phages hold promise as an antibiotic alternative, they encounter significant challenges in combating bacterial infections, primarily due to the emergence of phage-resistant bacteria. Bacterial defence mechanisms like superinfection exclusion, CRISPR, and restriction-modification systems can hinder phage effectiveness.
Pedro, Costa, Carla, Pereira, Jesús L, Romalde, Adelaide, Almeida   +3 more
openaire   +2 more sources

Development of an Acid-Protective Polymer Encapsulation Formulation for Oral Delivery of Salmonella Phages

Viruses
Bacteriophage therapy can successfully provide additional treatment to control Salmonella infection, but low gastric pH limits its oral application. The present study aimed to develop an improved encapsulation formulation with enhanced acid protection ...
Manju Bernela, Nitin Virmani, Bidhan Chand Bera, Rajesh Kumar Vaid, Medhavi Vashisth, Taruna Anand   +5 more
doaj   +1 more source