Potential of a phage cocktail in the treatment of multidrug-resistant Klebsiella pneumoniae pulmonary infection in mice. [PDF]
BMC MicrobiolThe emergence of multidrug-resistant Klebsiella pneumoniae, including carbapenem-resistant K. pneumoniae (CRKP), as one of the most common and notable superbugs, has long been a major threat to public health.
Gou Z +7 more
europepmc +2 more sources
A Two-Phage Cocktail Modulates Gut Microbiota Composition and Metabolic Profiles in an Ex Vivo Colon Model. [PDF]
Int J Mol SciBacteriophage therapy is a promising approach for targeting antibiotic-resistant bacteria and modulating gut microbiota in metabolic diseases such as obesity.
Rodríguez-Arellano SN +7 more
europepmc +2 more sources
Phage (cocktail)-antibiotic synergism: a new frontier in addressing <i>Klebsiella pneumoniae</i> resistance. [PDF]
Front MicrobiolPhages, which play a crucial role in regulating bacterial populations and evolution, have gained renewed attention as potential therapeutic agents especially in the face of rising antimicrobial resistance, such as in Klebsiella pneumoniae– a MDR pathogen
Karthika C +4 more
europepmc +2 more sources
Microbiology Spectrum, 2022 The rapid emergence of phage-resistant bacterial mutants is a major challenge for phage therapy. Phage cocktails have been considered one approach to mitigate this issue.
Dongyang Gao +9 more
doaj +2 more sources
A method for generation phage cocktail with great therapeutic potential. [PDF]
PLoS ONE, 2012 BACKGROUND: Bacteriophage could be an alternative to conventional antibiotic therapy against multidrug-resistant bacteria. However, the emergence of resistant variants after phage treatment limited its therapeutic application.
Jingmin Gu +11 more
doaj +4 more sources
Rapid formulation of a genetically diverse phage cocktail targeting uropathogenic Escherichia coli infections using the UTI89 model. [PDF]
Sci RepUrinary tract infections are commonly caused by uropathogenic Escherichia coli (UPEC). Due to the emergence of multidrug-resistant UPEC, rendering antibiotic treatment ineffective, phage combination-based therapy has been proposed as a potential ...
Kongsomboonchoke P +6 more
europepmc +2 more sources
Design of Phage-Cocktail-Containing Hydrogel for the Treatment of <i>Pseudomonas aeruginosa</i>-Infected Wounds. [PDF]
Viruses, 2023 Recently, the treatment of infected wounds has become a global problem due to increased antibiotic resistance in bacteria. The Gram-negative opportunistic pathogen Pseudomonas aeruginosa is often present in chronic skin infections, and it has become a ...
Shafigh Kheljan F +5 more
europepmc +2 more sources
In ovo administration of a phage cocktail partially prevents colibacillosis in chicks. [PDF]
Poult Sci, 2023 Avian pathogenic Escherichia coli (APEC) causes colibacillosis, the main bacterial disease in poultry leading to significant economic losses worldwide. Antibiotic treatments favor the emergence of multidrug-resistant bacteria, and preventive measures are
Nicolas M +8 more
europepmc +2 more sources
Effects of Phage Cocktail, Probiotics, and Their Combination on Growth Performance and Gut Microbiota of Broiler Chickens. [PDF]
Animals (Basel), 2023 Simple Summary The emergence of antibiotic-resistant bacteria and the growing demand for poultry products have led to an interest in finding alternatives to antibiotic growth promoters (AGPs) used in poultry farming.
Shaufi MAM +6 more
europepmc +2 more sources
A phage cocktail for drug-resistant mycobacteria [PDF]
Nature Reviews Microbiology, 2019 This study reports the use of a three-phage cocktail in the treatment of disseminated drug-resistant Mycobacterium abscessus.
openaire +4 more sources