Results 41 to 50 of about 140,627 (227)

A Novel Phage Cocktail Therapy of the Urinary Tract Infection in a Mouse Model [PDF]

Archives of Razi Institute, 2021
Escherichia coli (E. coli) is a major bacterial pathogen associated with many cases of serious infections, such as urinary tract infections (UTI) and meningitis intestinal.
B Mijbel Ali, S. A Gatea Kaabi, M. A Al-Bayati, H. K Musafer   +3 more
doaj   +1 more source

Rapid resistance evolution against phage cocktails [PDF]

When bacteria are treated with multiple antibiotics simultaneously, resistance is exceedingly unlikely to evolve. In stark contrast, resistance against multiple phages frequently arises during therapy. Why does resistance against multi-phage cocktails evolve so easily?
Baltus A. van der Steen, Matti Gralka, Yuval Mulla, Yuval Mulla   +3 more
openalex   +2 more sources

Bacteriophages Combined With Subtherapeutic Doses of Flucloxacillin Act Synergistically Against Staphylococcus aureus Experimental Infective Endocarditis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background The potential of phage therapy for the treatment of endovascular Staphylococcus aureus infections remains to be evaluated. Methods and Results The efficacy of a phage cocktail combining Herelleviridae phage vB_SauH_2002 and Podoviriae phage 66
Jonathan Save, Yok‐Ai Que, José M. Entenza, Camille Kolenda, Frédéric Laurent, Grégory Resch   +5 more
doaj   +1 more source

A New Pipeline for Designing Phage Cocktails Based on Phage-Bacteria Infection Networks [PDF]

Frontiers in Microbiology, 2021
In recent years, the spread of antibiotic-resistant bacteria and efforts to preserve food microbiota have induced renewed interest in phage therapy. Phage cocktails, instead of a single phage, are commonly used as antibacterial agents since the hosts are unlikely to become resistant to several phages simultaneously. While the spectrum of activity might
Felipe Molina, Alfredo Simancas, Manuel Ramírez, Rafael Tabla, Isidro Roa, José Emilio Rebollo   +5 more
openaire   +3 more sources

Sxt1, Isolated from a Therapeutic Phage Cocktail, Is a Broader Host Range Relative of the Phage T3. [PDF]

Viruses
Iarema P, Kotovskaya O, Skutel M, Drobiazko A, Moiseenko A, Sokolova O, Samitova A, Korostin D, Severinov K, Isaev A.   +9 more
europepmc   +3 more sources

Phage cocktail powder for Pseudomonas aeruginosa respiratory infections

International Journal of Pharmaceutics, 2021
Phage cocktail broadens the host range compared with a single phage and minimizes the development of phage-resistant bacteria thereby promoting the long-term usefulness of inhaled phage therapy. In this study, we produced a phage cocktail powder by spray drying three Pseudomonas phages PEV2 (podovirus), PEV1 and PEV20 (both myovirus) with lactose (80 ...
Mengyu, Li, Rachel Yoon Kyung, Chang, Yu, Lin, Sandra, Morales, Elizabeth, Kutter, Hak-Kim, Chan   +5 more
openaire   +3 more sources

Development of a Bacteriophage Cocktail to Constrain the Emergence of Phage-Resistant Pseudomonas aeruginosa

Frontiers in Microbiology, 2020
With the emergence of multidrug-resistant and extensively drug-resistant bacterial pathogens, phage therapy and other alternative or additional therapeutic modalities are receiving resurgent attention.
Yuhui Yang, Wei Shen, Qiu Zhong, Qian Chen, Xuesong He, Jonathon L. Baker, Kun Xiong, Xiaoling Jin, Jing Wang, Fuquan Hu, Shuai Le   +10 more
doaj   +1 more source

Inhibition of Antimicrobial-Resistant Escherichia coli Using a Broad Host Range Phage Cocktail Targeting Various Bacterial Phylogenetic Groups

Frontiers in Microbiology, 2021
Antimicrobial-resistant (AMR) commensal Escherichia coli is a major reservoir that disseminates antimicrobial resistance to humans through the consumption of contaminated foods, such as retail poultry products. This study aimed to control AMR E.
Jinshil Kim, Jinshil Kim, Haejoon Park, Haejoon Park, Sangryeol Ryu, Sangryeol Ryu, Byeonghwa Jeon   +6 more
doaj   +1 more source

A Method to Determine the Efficacy of a Commercial Phage Preparation against Uropathogens in Urine and Artificial Urine Determined by Isothermal Microcalorimetry

Microorganisms, 2022
Background: Urinary tract infections are commonly encountered and often treated with antibiotics. However, the inappropriate use of the latter has led to the appearance of resistant strains.
Aurelia Pahnita Sigg, Max Mariotti, Anabel E. Grütter, Tecla Lafranca, Lorenz Leitner, Gernot Bonkat, Olivier Braissant   +6 more
doaj   +1 more source

Characterization of 29 newly isolated bacteriophages as a potential therapeutic agent against IMP-6-producing Klebsiella pneumoniae from clinical specimens

Microbiology Spectrum, 2023
Carbapenemase-producing Enterobacteriaceae (CPE) are one of the most detrimental species of antibiotic-resistant bacteria globally. Phage therapy has emerged as an effective strategy for the treatment of CPE infections.
Kohei Kondo, Satoshi Nakano, Junzo Hisatsune, Yo Sugawara, Michiyo Kataoka, Shizuo Kayama, Motoyuki Sugai, Mitsuoki Kawano   +7 more
doaj   +1 more source