Results 61 to 70 of about 140,627 (227)

Synergy as a rationale for phage therapy using phage cocktails

PeerJ, 2014
Where phages are used to treat bacterial contaminations and infections, multiple phages are typically applied at once as a cocktail. When two or more phages in the cocktail attack the same bacterium, the combination may produce better killing than any single phage (synergy) or the combination may be worse than the best single phage (interference ...
Matthew Schmerer, Ian J. Molineux, James J. Bull   +2 more
openaire   +3 more sources

PhageCocktail: An R package to design phage cocktails from experimental phage-bacteria infection networks

Computer Methods and Programs in Biomedicine, 2022
Phage therapy is a resurgent strategy used in medicine and the food industry to lyse bacteria that cause damage to health or spoil a food product. Frequently, phage-bacteria infection networks have a large size, making it impossible to manually study all possible phage cocktails.
María Victoria Díaz-Galián, Miguel A. Vega-Rodríguez, Felipe Molina   +2 more
openaire   +2 more sources

Effective Treatment of Staphylococcus aureus Intramammary Infection in a Murine Model Using the Bacteriophage Cocktail StaphLyse™

Viruses, 2023
Staphylococcus aureus causes intramammary infections (IMIs), which are refractory to antibiotic treatment and frequently result in chronic mastitis. IMIs are the leading cause of conventional antibiotic use in dairy farms.
Eric Brouillette, Guillaume Millette, Suzanne Chamberland, Jean-Pierre Roy, Céline Ster, Tadele Kiros, Stephanie Hickey, Lauren Hittle, Joelle Woolston, François Malouin   +9 more
doaj   +1 more source

What Can We Learn from a Metagenomic Analysis of a Georgian Bacteriophage Cocktail?

Viruses, 2015
Phage therapy, a practice widespread in Eastern Europe, has untapped potential in the combat against antibiotic-resistant bacterial infections. However, technology transfer to Western medicine is proving challenging. Bioinformatics analysis could help to
Henrike Zschach, Katrine G. Joensen, Barbara Lindhard, Ole Lund, Marina Goderdzishvili, Irina Chkonia, Guliko Jgenti, Nino Kvatadze, Zemphira Alavidze, Elizabeth M. Kutter, Henrik Hasman, Mette V. Larsen   +11 more
doaj   +1 more source

Bacteriophage Cocktail Can Effectively Control Salmonella Biofilm in Poultry Housing

Frontiers in Microbiology, 2022
Salmonella enterica serovar Enteritidis (S. Enteritidis) is the major contaminant of poultry products, and its ability to form biofilms on produced food and poultry farm processing surfaces contributes to Salmonella transmission to humans. Bacteriophages
Paweł Korzeniowski, Paulina Śliwka, Maciej Kuczkowski, Dušan Mišić, Agata Milcarz, Marta Kuźmińska-Bajor   +5 more
doaj   +1 more source

Antibody Production in Response to Staphylococcal MS-1 Phage Cocktail in Patients Undergoing Phage Therapy [PDF]

Frontiers in Microbiology, 2016
In this study, we investigated the humoral immune response (through the release of IgG, IgA, and IgM antiphage antibodies) to a staphylococcal phage cocktail in patients undergoing experimental phage therapy at the Phage Therapy Unit, Medical Center of the Ludwik Hirszfeld Institute of Immunology and Experimental Therapy in Wrocław, Poland.
Maciej Żaczek, Marzanna Łusiak-Szelachowska, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Beata Weber-Dąbrowska, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Barbara Owczarek, Agnieszka Kopciuch, Wojciech Fortuna, Wojciech Fortuna, Paweł Rogóż, Andrzej Górski, Andrzej Górski, Andrzej Górski   +15 more
openaire   +3 more sources

Development of Phage Cocktails to Treat E. coli Catheter-Associated Urinary Tract Infection and Associated Biofilms

Frontiers in Microbiology, 2022
High rates of antimicrobial resistance and formation of biofilms makes treatment of Escherichia coli catheter-associated urinary tract infections (CAUTI) particularly challenging.
Belkys C. Sanchez, Emmaline R. Heckmann, Sabrina I. Green, Justin R. Clark, Heidi B. Kaplan, Robert F. Ramig, Kenneth L. Muldrew, Kenneth L. Muldrew, Kenneth L. Muldrew, Casey Hines-Munson, Felicia Skelton, Felicia Skelton, Barbara W. Trautner, Barbara W. Trautner, Barbara W. Trautner, Anthony W. Maresso   +15 more
doaj   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Correction to: multireceptor phage cocktail against Salmonella enterica to circumvent phage resistance. [PDF]

Microlife
europepmc   +2 more sources

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source