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Sequential Phage Delivery Can Outperform Cocktails by Delaying Cross-Resistance Evolution. [PDF]
Stuart EC, Meyer JR.
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Regulatory Harmonization Needs for Farm-to-Fork Bacteriophage Applications in South American Food Systems. [PDF]
Parra B +16 more
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Optimizing phage therapy with antidefense proteins acquired from the environment. [PDF]
Das R.
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Efficacy and Safety Outcomes of Bacteriophage Therapy for Resistant Bacterial Infections. [PDF]
Cho L, Chang H, Cho E, Rajagopal T.
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Phage and phage cocktails formulations
Progress in Molecular Biology and Translational Science, 2023Antibiotic-resistant bacterial infection is a major global problem and can be life-threatening. Bacteriophages or phages can be substituted choice over traditional antibiotics treatments. Phages are natural obligate parasites viruses of bacteria, and they can infect and kill antibiotic-sensitive and -resistant bacteria.
I Mani
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Phage Cocktails and the Future of Phage Therapy
Viruses of bacteria, known as bacteriophages or phages, were discovered nearly 100 years ago. Their potential as antibacterial agents was appreciated almost immediately, with the first 'phage therapy' trials predating Fleming's discovery of penicillin by approximately a decade.
Stephen T Abedon +2 more
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Computational design of phage cocktails based on phage-bacteria infection networks
Computers in Biology and Medicine, 2022The misuse and overuse of antibiotics have boosted the proliferation of multidrug-resistant (MDR) bacteria, which are considered a major public health issue in the twenty-first century. Phage therapy may be a promising way in the treatment of infections caused by MDR pathogens, without the side effects of the current available antimicrobials.
MIGUEL A Vega-Rodríguez, Felipe Molina
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Shopping for phages? Unpacking design rules for therapeutic phage cocktails
Current Opinion in Virology, 2022In bacteriophage therapy, the combination of different phages into a single cocktail is of critical importance to overcome the narrow host range of single phage isolates. Today, the design of therapeutic cocktails is often akin to a black box and relies largely on intuition and (pre-)availability of isolates in local collections.
Cédric Lood +3 more
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