Results 111 to 120 of about 149,596 (212)

Analysis of Selection Methods to Develop Novel Phage Therapy Cocktails Against Antimicrobial Resistant Clinical Isolates of Bacteria

bioRxiv, 2020
Antimicrobial resistance (AMR) is a major problem globally. The main bacterial organisms associated with urinary tract infection (UTI) associated sepsis are E. coli and Klebsiella along with Enterobacter species. These all have AMR strains known as ESBL (
M. Haines, F. E. Hodges, J. Y. Nale, J. Mahony, D. van Sinderen, Joanna Kaczorowska, Bandar Alrashid, M. Akter, Nathan Brown, Dominic Sauvageau, Thomas Sicheritz-Pontén, A. Thanki, A. Millard, E. Galyov, Martha R. J. Clokie   +14 more
semanticscholar   +1 more source

Phage Therapy as an Alternative Strategy Against Pseudomonas aeruginosa: A Narrative Review of Preclinical and Clinical Evidence

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Phage therapy shows promising efficacy against MDR, XDR, and PDR Pseudomonas aeruginosa infections across different models and administration routes. Evidence highlights reduced mortality, bacterial clearance, and synergy with antibiotics, while emphasizing the need for standardized protocols and advanced delivery systems to support clinical ...
Gustavo Aparecido da Cunha, Raine Piva Amaral, Ana Luisa Cauvila dos Santos, Bárbara Rafaela Ferreira Aio, Maria Fernanda Romboli Durante, Luiz Cosme Cotta Malaquias, Gabriel Magno de Freitas Almeida, Luiz Felipe Leomil Coelho   +7 more
wiley   +1 more source

Use of the Naturally Occurring Bacteriophage Grouping Model for the Design of Potent Therapeutic Cocktails

Antibiotics
The specificity of phages and their ability to evolve and overcome bacterial resistance make them potentially useful as adjuncts in the treatment of antibiotic-resistant bacterial infections.
Tea Glonti, Michael Goossens, Christel Cochez, Sabrina Green, Sayali Gorivale, Jeroen Wagemans, Rob Lavigne, Jean-Paul Pirnay   +7 more
doaj   +1 more source

Exploring the risks of phage application in the environment [PDF]

, 2013
This is an open access article that is freely available in ORE or from the publisher's web site. Please cite the published version.Interest in using bacteriophages to control the growth and spread of bacterial pathogens is being revived in the wake of ...
Koskella, Britt, Meaden, Sean
core   +3 more sources

Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for Their Synthesis

ChemistryEurope, Volume 4, Issue 5, May 2026.
Screening of chemical libraries has over the past decades become a cornerstone of drug discovery. Today, a broad range of chemical libraries exist but they are often not well described in terms of diversity. This review describes current efforts which aim to visualize chemical diversity in compound collections and discuss current trends in synthetic ...
Tobias N. Hansen, Nils J. V. Hansen
wiley   +1 more source

Antigen presenting capacity of murine splenic myeloid cells [PDF]

, 2017
BACKGROUND: The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised although dendritic cell (DC) subsets are
Hey, Ying-Ying, O'Neill, Helen C, Quah, Benjamin   +2 more
core   +2 more sources

Gut Dysbiosis as a Shared Mechanism in Obesity and Hypertension: Exploring a Promising Therapeutic Avenue

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This review synthesises current knowledge on gut microbiome involvement in obesity and hypertension, evaluates microbiome‐based therapeutic strategies, and identifies critical research gaps to guide future investigations aimed at mitigating the dual pandemics.
Andrej Belančić, Almir Fajkić, Yusuf Ziya Sener, Ana Jelaković, Lejla Alić, Elvira Meni Maria Gkrinia, Donatella Verbanac, Bojan Jelaković   +7 more
wiley   +1 more source

Efficacy of a phage cocktail in controlling phage resistance development in multidrug resistant Acinetobacter baumannii

Virus Research, 2019
The control and treatment of multidrug resistant pathogens infections has become a grand challenge for clinicians worldwide. Virulent phage has long been considered as an effective bactericidal agent, which may be a potentially alternative to antibiotics.
Yuyu, Yuan, Lili, Wang, Xiaoyu, Li, Demeng, Tan, Cong, Cong, Yongping, Xu   +5 more
openaire   +2 more sources

Efficacy of a Salmonella Bacteriophage Cocktail Against Multidrug‐Resistant Salmonella Isolates From Clinical and Food Samples

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Introduction Salmonella is a significant foodborne pathogen responsible for severe gastroenteritis and systemic infections in humans and animals. The increasing prevalence of antimicrobial‐resistant Salmonella strains poses a major public health challenge.
Taras Gabisonia, Manana Loladze, Maia Zarnadze, Natia Tamarashvili, Natela Chakhunashvili, Manana Nadiradze, Maia Alibegashvili, Tatiana Eliava, Tamar Kalandarishvili, Teimuraz Katamadze   +9 more
wiley   +1 more source

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. [PDF]

, 2011
Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine.
Ashley, Carlee E, Brinker, C Jeffrey, Brown, Page A, Carnes, Eric C, Carroll, Nick J, Carter, Mark B, Chackerian, Bryce, Dunphy, Darren R, Durfee, Paul N, Evans, Deborah G, Hanna, Tracey N, Jiang, Xingmao, Liu, Juewen, Padilla, David, Parikh, Atul N, Peabody, David S, Petsev, Dimiter N, Phillips, Brandy, Phillips, Genevieve K, Wharton, Walker, Willman, Cheryl L   +20 more
core   +2 more sources