Results 121 to 130 of about 149,596 (212)

Development of CAR Exosomes Targeting FAP for the Treatment of Intrauterine Adhesion

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Engineered extracellular vesicles (EVs) have emerged as promising cell‐free platforms for immunomodulation and tissue repair. In this study, we generated EVs derived from chimeric antigen receptor (CAR) T cells targeting fibroblast activation protein (FAP) and investigated their biological and therapeutic functions.
Wenyan Fu, Kewen Qian, Hongru Ai, Yitan Zou, Yaping Zhou, Ruixue Mao, Jian Zhao, Changhai Lei, Shi Hu   +8 more
wiley   +1 more source

Phages & antibiotic resistance: are the most abundant entities on earth ready for a comeback? [PDF]

, 2018
Bacteriophages, which lost out to antibiotic therapy in the past, may be poised to make a comeback. Once discarded because of their narrow activity spectrum, it can now be viewed as a major advantage that these intracellular, self-replicating entities ...
Hill, Colin, Mills, Susan, Ross, R. Paul
core   +1 more source

Viable but Nonculturable State, a Survival Strategy for Salmonella in Aquatic Environments

Water and Environment Journal, Volume 40, Issue 2, Page 183-202, May 2026.
Transition of Salmonella from a culturable state to a viable but nonculturable state under various environmental stresses and current methods for detecting viable Salmonella in environmental samples. ABSTRACT In the relentless battle for survival, Salmonella has evolved mechanisms to withstand harsh conditions such as extreme temperatures, fluctuating ...
Sanelisiwe Thinasonke Duze, Musa Marimani, Katlego Mamabolo, Mrudula Patel   +3 more
wiley   +1 more source

Enzyme‐Assisted Synthesis and In Vitro Characterization of Bifunctional PCSK9 Inhibitors

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important therapeutic target for lowering cholesterol. Here, we report the assembly of a bifunctional molecule combining a PCSK9‐binding peptide with an asialoglycoprotein receptor (ASGPR) ligand.
Yuhui Zhang, Li Wang, Leo Corcilius, Amal K. Reji, Richard J. Payne, Bin Hong, Thomas Durek, Conan K. Wang, David J. Craik   +8 more
wiley   +1 more source

A New Approach for Phage Cocktail Design in the Example of Anti-Mastitis Solution

Pathogens
The studies on phage therapy have shown an overall protective effect of phages in bacterial infections, thus providing an optimistic outlook on the future benefits of phage-based technologies for treating bacterial diseases.
Daria Królikowska, Marta Szymańska, Marta Krzyżaniak, Arkadiusz Guziński, Rafał Matusiak, Agnieszka Kajdanek, Edyta Kaczorek-Łukowska, Agnieszka Maszewska, Ewelina A. Wójcik, Jarosław Dastych   +9 more
doaj   +1 more source

Phage sensitivity and prophage carriage in Staphylococcus aureus isolated from foods in Spain and New Zealand [PDF]

, 2016
Bacteriophages (phages) are a promising tool for the biocontrol of pathogenic bacteria, including those contaminating food products and causing infectious diseases.
Billington, Craig, Garcia, Pilar, Garcia, Pilar, Gutierrez, Diana, Martinez, Beatriz, Premarante, Aruni, Rodriguez, Ana, Rodriguez-Rubio, Lorena   +7 more
core   +1 more source

Ackermannviridae bacteriophage against carbapenem-resistant Klebsiella pneumoniae of capsular type 64

Frontiers in Microbiology
Lytic bacteriophages (phages) are promising clinically viable therapeutic options against carbapenem-resistant Klebsiella pneumoniae (CRKP). In China, the predominant strains are those assigned to sequence type 11 and capsular type 64 (ST11-KL64).
Juan Li, Juan Li, Yu Feng, Huan Luo, Qingqing Fang, Qingqing Fang, Yongqiang Yang, Zhiyong Zong, Zhiyong Zong, Zhiyong Zong, Zhiyong Zong   +10 more
doaj   +1 more source

Phages anti-Pseudomonas aeruginosa pour le traitement des plaies brûlées infectées. Evaluation in vitro et résultats préliminaires de la mise au point d'un modèle ex vivo. [PDF]

, 2015
Les bactériophages sont des virus spécifiques aux bactéries. Ils ont été découverts au début du 20ème siècle en France. Les premières études les concernant comme thérapie pour les infections bactériennes ont été conduites par Felix D'He ...
AL-DOUROBI, K.
core  

Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice [PDF]

, 2019
We investigated the contribution of human platelets to macrophage effector properties in the presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for platelet transfusion in septic animals.
Carestia, Agostina, Carrera Silva, Eugenio Antonio, Errasti, Andrea Emilse, Gomez, Ricardo Martin, Jenne, Craig N., Mena, Hebe Agustina, Negrotto, Soledad, Olexen, Cinthia Mariel, Ortiz Wilczyñski, Juan Manuel, Schattner, Mirta Ana   +9 more
core   +1 more source

FORMULATING PHAGE COCKTAILS AS ADJUVANT THERAPY IN CARBAPENEM-RESISTANT PSEUDOMONAS AERUGINOSA

Open Respiratory Archives
Introduction: Phage-antibiotic synergy (PAS) results in bacterial killing beyond the efficacy of either agent alone. Although the main candidates for therapeutic PAS are lytic phages, temperate phages have been re-evaluated in light of PAS.
Viviane de Cássia Oliveira, Amanda Carolina Souza Delfino da Rocha, Alba Soler-Comas, Guillen Macip, Miguel Ferrer, Antoni Torres, Laia Fernandez-Barat   +6 more
doaj   +1 more source