Results 111 to 120 of about 121,778 (347)
Advanced Science, EarlyView.Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen +22 more
wiley +1 more source
Phage Display Libraries for Antibody Therapeutic Discovery and Development
Antibodies, 2019 Phage display technology has played a key role in the remarkable progress of discovering and optimizing antibodies for diverse applications, particularly antibody-based drugs.
Juan C. Almagro +3 more
doaj +1 more source
Phage displayed peptides/antibodies recognizing growth factors and their tyrosine kinase receptors as tools for anti-cancer therapeutics. [PDF]
, 2012 The basic idea of displaying peptides on a phage, introduced by George P. Smith in 1985, was greatly developed and improved by McCafferty and colleagues at the MRC Laboratory of Molecular Biology and, later, by Barbas and colleagues at the Scripps ...
Benzoni P +4 more
core +3 more sources
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
High throughput functional epitope mapping: Revisiting phage display platform to scan target antigen surface [PDF]
, 2014 Gertrudis Rojas +2 more
openalex +1 more source
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao +36 more
wiley +1 more source
The Escherichia coli glycophage display system [PDF]
, 2017 We describe a phage display technique that allows the production and selective enrichment of phages that display an N-glycoprotein (glycophages). We applied glycophage display to select functional glycosylation sequons from a pool of randomized acceptor ...
Aebi, Markus +4 more
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Biopanning for Banana streak virus Binding Peptide by Phage Display Peptide Library [PDF]
, 2007 Kek Heng Chua +3 more
openalex +1 more source
Advanced Science, EarlyView.We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta +7 more
wiley +1 more source
Expanding phage display technology with luminescence [PDF]
, 2014 EMBO Conference on Viruses of Microbes III: Structure and Function - from Molecules to Communities (Programme and Abstract Book)[Excerpt] The -omics Era has contributed to the disclosure of genes coding for known and novel biologically active peptides ...
Azeredo, Joana +2 more
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