Results 251 to 260 of about 73,738 (335)

Pioneer: a synthetic human antibody phage display library for rapid therapeutic lead generation. [PDF]

MAbs
Putyrski M, Hentrich C, Cavada M, Wich M, Kellmann SJ, Hanselka S, Eick-Werner M, Hanuschka H, Preis W, Werkmeister C, Klee M, Knappik A, Ylera F.   +12 more
europepmc   +1 more source

In Salmonella Typhimurium, YiiD Modulates cAMP Levels in Lag Phase During Growth on Succinate

Molecular Microbiology, EarlyView.
The YiiD enzyme, found by others to perform a redundant role in fatty acid biosynthesis, is found to be unexpectedly required for the early increase in cAMP in lag phase during growth on succinate. This intriguing finding suggests a mechanistic link may exist between fatty acid biosynthesis and catabolite repression. ABSTRACT In Salmonella Typhimurium (
John A. Ciemniecki, Jessica L. Will, Jorge C. Escalante‐Semerena   +2 more
wiley   +1 more source

Immune Imprinting Identified in Phage-Display Antibody Libraries Derived from Early Wild-Type and Late Omicron COVID-19 Convalescents. [PDF]

Viruses
Li B, Wang M, Huang F, Wu W, Fan J, Yang L, Pan Y, Liang M, Duan K.   +8 more
europepmc   +1 more source

Regulation of the Yersinia pseudotuberculosis Type III Secretion System by the CpxAR Two‐Component System

Molecular Microbiology, EarlyView.
Host tissue cues including temperature, oxygen, and iron availability regulate expression of the Yersinia type III secretion system (T3SS) master regulator LcrF. We found that CpxR inhibits LcrF through an indirect, multi‐factorial mechanism and identified the osmolarity‐sensing OmpR/EnvZ system as an additional regulator of LcrF, highlighting ...
Karen Hug, Erin Mettert, Melissa Estrada Escobar, Cristina Vargas Vazquez, David Balderas, Sarvind Tripathi, Laya Ashley, Patricia J. Kiley, Victoria Auerbuch   +8 more
wiley   +1 more source

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility

Molecular Microbiology, EarlyView.
Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohaghegh, Jacob Scadden, Matthew A. B. Baker   +2 more
wiley   +1 more source

The 3D genome of Gigaspora margarita unveils stable chromatin and nucleolar organization and symbiont‐dependent genome dynamics

New Phytologist, EarlyView.
Summary Arbuscular mycorrhizal fungi (AMF) are widespread plant symbionts that enhance nutrient acquisition and influence ecosystem productivity. Previous chromosome‐level assemblies of the model species Rhizophagus irregularis revealed a two‐compartment genome architecture (active A and repressed B chromatin compartments), yet its conservation across ...
Ken Mugambi, Jordana Oliveira, Franco Magurno, Alessandra Salvioli di Fossalunga, Mara Novero, Luisa Lanfranco, Stefano Ghignone, Gökalp Yildirir, Yan Wang, Paola Bonfante, Nicolas Corradi   +10 more
wiley   +1 more source

High-Throughput Identification and Characterization of LptDE-Binding Bicycle Peptides Using Phage Display and Cryo-EM. [PDF]

J Med Chem
Allyjaun S, Dunbar E, Hardwick SW, Newell S, Holding F, Rowland CE, St Denis MA, Pellegrino S, Arruda Bezerra G, Bournakas N, Chirgadze DY, Cooper L, Paris G, Lewis N, Brown P, Skynner MJ, Dawson MJ, Beswick P, Hubbard J, van den Berg B, Newman H.   +20 more
europepmc   +1 more source

Oral Microbiome in Systemic Autoimmune Diseases: A Systematic Review

Oral Diseases, EarlyView.
ABSTRACT Objective The oral cavity represents a key but underexplored interface between host immunity and microbial communities. The aim of this systematic review was to synthesize current literature on oral microbiota alterations in systemic autoimmune diseases.
Sophie Jung, Eirini Militsi, Olivier Huck   +2 more
wiley   +1 more source

Defining short linear motif binding determinants by phage display-based deep mutational scanning. [PDF]

Protein Sci
Benz C, Maassen L, Simonetti L, Mihalic F, Lindqvist R, Tsitsa I, Konstantinou A, Jemth P, Överby AK, Davey NE, Ivarsson Y.   +10 more
europepmc   +1 more source