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In vivo phage display identifies novel peptides for cardiac targeting. [PDF]

open access: yesSci Rep
Ivanova A   +12 more
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Antibody Phage Display

2023
The application of antibodies has transcended across many areas of work but mainly as a research tool, for diagnostic and for therapeutic applications. Antibodies are immunoproteins from vertebrates that have the unique property of specifically binding foreign molecules and distinguish target antigens.
Alia, Nur   +6 more
openaire   +2 more sources

Phage Display

2012
Phage display has emerged as one of the leading technologies for the selection and generation of highly specific antibodies, offering a number of advantages over traditional ways of antibody generation such as mouse hybridoma techniques. While there are various possibilities to conduct phage display, selection of antibodies via solution panning is an ...
  +5 more sources

Phage Display Technology

2000
The development of monoclonal antibody (mAb) technology (1) has had a significant impact on many fields of research, in particular immunology. However, the method has limitations. The use of recombinant DNA technology and demonstration by Smith 1985 (2) that peptides can be expressed on the surface of filamentous bacteriophages have permitted the ...
M, Johns, D B, Palmer
openaire   +4 more sources

Phage Displayed Peptide Libraries

Combinatorial Chemistry & High Throughput Screening, 1999
Peptide libraries may be constructed by grafting, in vitro, random DNA sequences into a carrier gene and then introducing the degenerate hybrid coding sequence into an expression organism. This review will focus on phage display, which was the first expression organism for peptide library expression to be described and which still maintains ...
Cesareni G, Castagnoli L, Cestra G
openaire   +3 more sources

Metasecretome Phage Display

2017
Metasecretome is a collection of cell-surface and secreted proteins that mediate interactions between microbial communities and their environment. These include adhesins, enzymes, surface structures such as pili or flagella, vaccine targets or proteins responsible for immune evasion.
Milica, Ciric   +3 more
openaire   +2 more sources

Phage display

Immunotechnology, 1995
Phage display is a powerful method for the selection and evolution of proteins and peptides. Applications include the generation of potent and novel antibodies, the in vitro improvement of protein affinity and function, epitope discovery, the development of leads for vaccine research and the identification of interacting proteins using cDNA libraries.
openaire   +2 more sources

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