Results 141 to 150 of about 165,430 (355)

Coordinated gene expression within sustained STAT3‐associated chromatin conformations contributes to hepatocellular carcinoma progression

open access: yesCancer Communications, EarlyView.
Abstract Background Phosphorylated signal transducer and activator of transcription 3 (p‐STAT3) has emerged as a critical modulator of hepatocellular carcinoma (HCC) progression. However, its role in three‐dimensional (3D) chromatin conformation and the expression of genes linked to HCC aggressiveness remains largely unexplored.
Sunyoung Jang   +9 more
wiley   +1 more source

Role of the host cell in bacteriophage T4 development. II. Characterization of host mutants that have pleiotropic effects on T4 growth [PDF]

open access: yes, 1980
Mutant host-defective Escherichi coli that fail to propagate bacteriophage T4 and have a pleiotropic effect on T4 development have been isolated and characterized.
Lielausis, Ilga   +3 more
core  

Differential amplification of specific areas of phage T4 genome as revealed by hybridization to cloned genetic segments. [PDF]

open access: green, 1980
Andrzej W. Kozinski   +4 more
openalex   +1 more source

Hijacking the Electron Train: Menaquinone‐Binding Antimicrobial Peptides

open access: yesChemBioChem, EarlyView.
Menaquinone is an emerging target for antimicrobial peptides. Could it be the new Achilles’ Heel of bacteria? The rise of antibiotic resistance threatens to undermine modern medicine, making the development of new antibiotics and novel targets an urgent priority.
Eilidh J. Matheson, Stephen A. Cochrane
wiley   +1 more source

The analysis of the function, diversity, and evolution of the Bacillus phage genome. [PDF]

open access: yesBMC Microbiol, 2023
Zhang Y   +6 more
europepmc   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal   +14 more
wiley   +1 more source

Improved single-swab sample preparation for recovering bacterial and phage DNA from human skin and wound microbiomes. [PDF]

open access: yes, 2019
BackgroundCharacterization of the skin and wound microbiome is of high biomedical interest, but is hampered by the low biomass of typical samples. While sample preparation from other microbiomes (e.g., gut) has been the subject of extensive optimization,
Chen, Irene A   +3 more
core   +1 more source

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