Results 121 to 130 of about 1,053,752 (301)

Phage Genomics [PDF]

Cell, 2002
Brüssow, Harald, Hendrix, Roger W.
openaire   +1 more source

Genomic Conservation in Phage Whytu and Other Small Phages

, 2020
Arthrobacter globiformis phage Whytu was isolated from a California soil sample; sequencing revealed one of the smallest Actinobacteriophage genomes. Using comparative genomics, we compared Whytu to other Actinobacteriophages that infect different hosts.
Fett, Sarah, Rahman, Mujtahid, Tse, Vincent, Vargas, Aida, Kapinos, Andrew, Torres, Canela, Reddi, Krisanavane, Moberg Parker, Jordan, Freise, Amanda   +8 more
openaire   +1 more source

Comprehensive analysis of phage genomes from diverse environments reveals their diversity, potential applications, and interactions with hosts and other phages

Frontiers in Microbiology
Phages are ubiquitous and diverse, playing a key role in maintaining microbial ecosystem balance. However, their diversity, potential applications, and their interactions with hosts and other phages remain largely unexplored.
Chao Wei, Zhe Chen
doaj   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Genome Sequence of Mycobacterium Phage Guppsters.

microPublication biology
Mycobacterium Phage Guppsters was isolated on Mycobacterium smegmatis mc 2 155, displays a siphovirus morphology, and possesses a 54,835 base pair genome. Based on gene content similarity, Guppsters is assigned to cluster F1. Unlike a majority of F1 phages, Guppsters does not encode mycobacteriophage mobile elements.
Alley, Emma K, Hill, Lexi C, Houglum, Mya E, Lamppa, Maggie R, Pack, Khailee K, Pageau, Hailey D, Prosen, Cale J, Richards, Kylie R, Royer, Kendra S, Slettedahl, Emily A, Strusz, Ian L, Wiita, Lydia A, Zeidler, Jillian C, Westholm, Daniel E   +13 more
openaire   +2 more sources

Complete Pathway Refactoring and Combinatorial Biosynthesis of Anthracyclines for Modulation of Histone Eviction and DNA Damage Bioactivities

Angewandte Chemie, EarlyView.
A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang, Heli Tirkkonen, Sabina Y. van der Zanden, Larissa Ponomareva, Isaline Fagon, Leslie Fève, Kendall Paige, Courtney L. Brown, Nora Schwartz, Jacob Hecht, Jennifer Nguyen, Jon S. Thorson, Jacques Neefjes, S. Eric Nybo, Khaled A. Shaaban, Mikko Metsä‐Ketelä   +15 more
wiley   +2 more sources

Combining Comprehensive Analysis of Off-Site Lambda Phage Integration with a CRISPR-Based Means of Characterizing Downstream Physiology

mBio, 2017
During its lysogenic life cycle, the phage genome is integrated into the host chromosome by site-specific recombination. In this report, we analyze lambda phage integration into noncanonical sites using next-generation sequencing and show that it ...
Yu Tanouchi, Markus W. Covert
doaj   +1 more source

Genome Sequence of Arthrobacter sp. Phage Scuttle

, 2020
Arthrobacter phage Scuttle was isolated by enrichment from a dry soil sample (collected in Upper Darby, Pennsylvania) on host Arthrobacter sp. ATCC 21022.

core   +1 more source

Determination of Gene‐Level Fitness Contributions Across the Mucin‐Utilization Network of Bacteroides thetaiotaomicron

Advanced Science, EarlyView.
Genome‐wide CRISPRi and RNA‐seq resolve how B. thetaiotaomicron converts host mucosal glycans into fitness. The study reveals a layered mucin‐utilization architecture in which capsular polysaccharides constrain surface access, extracellular CAZymes and peptidases show functional redundancy, and intracellular catabolic pathways create discrete metabolic
Kangsan Kim, Jiwon Lee, Minjeong Kang, Sung Sun Yim, Donghui Choe, Byung‐Kwan Cho   +5 more
wiley   +1 more source

Synthesis of Headful Packaging Phages Through Yeast Transformation-Associated Recombination

Viruses
De novo synthesis of phage genomes enables flexible genome modification and simplification. This study explores the synthetic genome assembly of Pseudomonas phage vB_PaeS_SCUT-S4 (S4), a 42,932 bp headful packaging phage, which encapsidates a terminally ...
Cheng Lu, Lan He, Yangyijun Guo, Tingting Wang, Yanrui Ye, Zhanglin Lin   +5 more
doaj   +1 more source