Results 101 to 110 of about 190,753 (310)
Comparative Genomic Analysis of 130 Bacteriophages Infecting Bacteria in the Genus Pseudomonas
Frontiers in Microbiology, 2018 Bacteria of the genus Pseudomonas are genetically diverse and ubiquitous in the environment. Like other bacteria, those of the genus Pseudomonas are susceptible to bacteriophages which can significantly affect their host in many ways, ranging from cell ...
Anh D. Ha, Dee R. Denver
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Molecular bases and role of viruses in the human microbiome. [PDF]
, 2014 Viruses are dependent biological entities that interact with the genetic material of most cells on the planet, including the trillions within the human microbiome.
Abeles, Shira R, Pride, David T
core +1 more source
Advanced Science, EarlyView.When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Genome Sequence of Serratia marcescens Phage BF [PDF]
Genome Announcements, 2017 ABSTRACTPhages infectingSerratia marcescens, a common causative agent of nosocomial infections, have potential therapeutic applications. Here, we report the complete genome of the novelS. marcescensphage BF, representing the third-largest phage genome sequenced to date.
Casey E. +5 more
openaire +3 more sources
Viruses, 2018 Phages, the parasites of bacteria, are considered as a new kind of antimicrobial agent due to their ability to lyse pathogenic bacteria. Due to the increase of available phage isolates, the newly isolated phage showed increasing genomic similarities with
Yihui Yuan +6 more
doaj +1 more source
Modeling the architecture of depolymerase-containing receptor binding proteins in Klebsiella phages [PDF]
, 2019 Klebsiella pneumoniae carries a thick polysaccharide capsule. This highly variable chemical structure plays an important role in its virulence. Many Klebsiella bacteriophages recognize this capsule with a receptor binding protein (RBP) that contains a ...
Briers, Yves +3 more
core +2 more sources
Multi‐Targeting Non‐Specific Genome Engineering in Bacteria
Advanced Science, EarlyView.In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun +7 more
wiley +1 more source
Frontiers in Microbiology, 2018 Xanthomonas euvesicatoria phage KΦ1, a member of Myoviridae family, was isolated from the rhizosphere of pepper plants showing symptoms of bacterial spot. The phage strain expressed antibacterial activity to all X.
Katarina Gašić +5 more
doaj +1 more source
The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction [PDF]
, 2016 Gene therapy has long been regarded as a promising treatment for cancer. However, cancer gene therapy is still facing the challenge of targeting gene delivery vectors specifically to tumors when administered via clinically acceptable non-invasive ...
Albahrani, M +5 more
core +2 more sources