Results 91 to 100 of about 125,595 (262)

Design of experiments‐guided membrane capture facilitates integration of continuous virus inactivation using Phi6 as a surrogate virus in an intensified downstream process

Biotechnology Progress, EarlyView.
Abstract The growing demand for cost‐efficient and flexible biomanufacturing has increased interest in process‐intensified downstream platforms. This study evaluates an intensified monoclonal antibody (mAb) purification sequence, where two unit operations traditionally performed in batch mode—Protein A capture and low pH virus inactivation (VI)—are ...
Mario Grünberg, Lisa Lipski, Gabriel Fisicaro, Thomas Duvignau, Karolina Meyer‐Heinrichs, Diana Carmen Mocsy, Thomas‐Josef Filz, Bastian Quaas, Alexandra Stützer   +8 more
wiley   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Synthesis of Headful Packaging Phages Through Yeast Transformation-Associated Recombination

Viruses
De novo synthesis of phage genomes enables flexible genome modification and simplification. This study explores the synthetic genome assembly of Pseudomonas phage vB_PaeS_SCUT-S4 (S4), a 42,932 bp headful packaging phage, which encapsidates a terminally ...
Cheng Lu, Lan He, Yangyijun Guo, Tingting Wang, Yanrui Ye, Zhanglin Lin   +5 more
doaj   +1 more source

Genomic Conservation in Phage Whytu and Other Small Phages

, 2020
Arthrobacter globiformis phage Whytu was isolated from a California soil sample; sequencing revealed one of the smallest Actinobacteriophage genomes. Using comparative genomics, we compared Whytu to other Actinobacteriophages that infect different hosts.
Fett, Sarah, Rahman, Mujtahid, Tse, Vincent, Vargas, Aida, Kapinos, Andrew, Torres, Canela, Reddi, Krisanavane, Moberg Parker, Jordan, Freise, Amanda   +8 more
openaire   +1 more source

Integrative host–microbiome modeling uncovers the implication of oral–gut translocation in advanced cirrhosis

iMeta, EarlyView.
Liver cirrhosis is associated with profound disruption of host–microbiome metabolic interactions. Using paired oral and fecal metagenomics combined with genome‐scale metabolic modeling, we investigated how microbial translocation along the oral–gut axis influences microbial metabolism at different cirrhosis severities.
Yi Jin, Frederick Clasen, Fernando Garcia‐Guevara, Sania Arif, Robert Schierwagen, Gholamreza Bidkhori, Michael Praktiknjo, Maximilian J. Brol, Frank E. Uschner, Florence A. Castelli, Nicolas Pons, Benoit Quinquis, Nathalie Galleron, Kevin Da Silva, Christophe Junot, Debbie L. Shawcross, David L. Moyes, Rajiv Jalan, S. Dusko Ehrlich, Vishal C. Patel, Jonel Trebicka, Saeed Shoaie   +21 more
wiley   +1 more source

Isolation and genomic analysis of phage BUCT551 against drug-resistant Aeromonas hydrophila

Frontiers in Veterinary Science
Aeromonas hydrophila (A. hydrophila) is a common pathogen in aquaculture that also causes opportunistic infections and sporadic food- and water-borne illness in humans.
Pengjun Han, Pengjun Han, Hongbo Qin, Chenxi Hao, Zhiping Du, Yang Yang, Yang Yang   +6 more
doaj   +1 more source

Synthetic microbial communities for engineering climate‐smart biofertilizers

iMeta, EarlyView.
Global agricultural productivity is increasingly destabilized by climate change—driven droughts, floods, extreme heat, and severe storms. Although the climate‐smart agriculture (CSA) framework addresses these challenges, implementation has focused mainly on plant genetics and agronomic inputs, leaving the adaptive potential of the crop microbiome ...
Yan Liu, Yue Chen, Yanxue Yu, Che Ok Jeon, Mohammad Bahram, Junfeng Zhai, Hailei Wei, Fuqiang Wang, Xiaofeng Cao, Baolei Jia   +9 more
wiley   +1 more source

Isolation and Genome Characterization of the Virulent Staphylococcus aureus Bacteriophage SA97

Viruses, 2015
A novel bacteriophage that infects S. aureus, SA97, was isolated and characterized. The phage SA97 belongs to the Siphoviridae family, and the cell wall teichoic acid (WTA) was found to be a host receptor of the phage SA97.
Yoonjee Chang, Hakdong Shin, Ju-Hoon Lee, Chul Jong Park, Soon-Young Paik, Sangryeol Ryu   +5 more
doaj   +1 more source

PhamClust: a phage genome clustering tool using proteomic equivalence. [PDF]

mSystems, 2023
Gauthier CH, Hatfull GF.
europepmc   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source