Results 81 to 90 of about 126,149 (256)

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Genomic characterization of APEC phages and evaluation of the efficacy in reducing the loads of APEC O78 infections in chickens

Frontiers in Microbiology
IntroductionThe resistance of avian pathogenic Escherichia coli (APEC) poses a serious challenge to the control of bacterial diseases in the poultry industry.
Qin Lu, Xinxin Jin, Xinxin Jin, Zui Wang, Rongrong Zhang, Rongrong Zhang, Yunqing Guo, Yunqing Guo, Qiao Hu, Qiao Hu, Wenting Zhang, Wenting Zhang, Tengfei Zhang, Tengfei Zhang, Qingping Luo, Qingping Luo, Qingping Luo   +16 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Genomic Conservation in Phage Whytu and Other Small Phages

, 2020
Arthrobacter globiformis phage Whytu was isolated from a California soil sample; sequencing revealed one of the smallest Actinobacteriophage genomes. Using comparative genomics, we compared Whytu to other Actinobacteriophages that infect different hosts.
Fett, Sarah, Rahman, Mujtahid, Tse, Vincent, Vargas, Aida, Kapinos, Andrew, Torres, Canela, Reddi, Krisanavane, Moberg Parker, Jordan, Freise, Amanda   +8 more
openaire   +1 more source

Complete Genome of the Xanthomonas euvesicatoria Specific Bacteriophage KΦ1, Its Survival and Potential in Control of Pepper Bacterial Spot

Frontiers in Microbiology, 2018
Xanthomonas euvesicatoria phage KΦ1, a member of Myoviridae family, was isolated from the rhizosphere of pepper plants showing symptoms of bacterial spot. The phage strain expressed antibacterial activity to all X.
Katarina Gašić, Nemanja Kuzmanović, Milan Ivanović, Anđelka Prokić, Milan Šević, Aleksa Obradović   +5 more
doaj   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Структурні та генетичні особливості літичного бактеріофага Lw1, нового представника псевдо Т-парних фагів

Фактори експериментальної еволюції організмів, 2015
Aims. Bacteriophages are diverse group of bacterial parasites which have complex, but insufficient systematics. RB43-related bacteriophages have a specific genome type that clearly distinguishes them from other T4-like viruses.
А. І. Кушкіна
doaj  

Challenges and Future Directives of Synthetic Biology in Engineering Plant–Microbe Partnerships for Sustainable Agriculture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Synthetic biology has recently proven to be a valuable tool for enhancing agriculture even in the face of environmental and biological stresses. Understanding the challenges that militate synthetic biology will assist in ensuring safe, stable, and scalable crop production.
Ben Jesuorsemwen Enagbonma, Rebaona Reaobaka Molefe‐Madlaliso, Alaba Adewole Adebayo, Oghoye Priscilla Oyedoh, Godfrey Okainemen Oribhabor, Oluwaseun Emmanuel Shittu, Olubukola Oluranti Babalola   +6 more
wiley   +1 more source

A novel tail fiber protein triggers phage DNA ejection by recognizing lipopolysaccharides of K54 hypervirulent Klebsiella pneumoniae

Microbiology Spectrum
Bacteriophage (phage) therapy is a promising alternative antibacterial approach for treating infectious diseases by hvKp. However, there has been a lack of studies on the host recognition and infection initiation of hvKp phages.
Ming Yin, Li Cao, Yu Fu, Yanjun Lu, Yi Yan, Lvxin Qian, Li Xiang, Tiejun Zhou, Huan Chen, Ying Li, Luhua Zhang   +10 more
doaj   +1 more source

Scalable Separation and Purification of M13‐Bacteriophage‐Derived Particles Containing Artificial Single‐Stranded DNA Produced by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Single‐stranded DNA (ssDNA) solutions are promising innovations shaping the future of genetic research and medical therapies. In principle, biotechnological mass production of ssDNA can be achieved using Escherichia coli in a high‐cell density fed‐batch process by secreting phagemid particles derived from the filamentous M13 bacteriophages ...
Nathalie Hafner, Wiebke Winkler, Maximilian N. Honemann, Hendrik Dietz, Dirk Weuster‐Botz   +4 more
wiley   +1 more source