Results 111 to 120 of about 190,753 (310)

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

Genomic characterization of APEC phages and evaluation of the efficacy in reducing the loads of APEC O78 infections in chickens

Frontiers in Microbiology
IntroductionThe resistance of avian pathogenic Escherichia coli (APEC) poses a serious challenge to the control of bacterial diseases in the poultry industry.
Qin Lu, Xinxin Jin, Xinxin Jin, Zui Wang, Rongrong Zhang, Rongrong Zhang, Yunqing Guo, Yunqing Guo, Qiao Hu, Qiao Hu, Wenting Zhang, Wenting Zhang, Tengfei Zhang, Tengfei Zhang, Qingping Luo, Qingping Luo, Qingping Luo   +16 more
doaj   +1 more source

Biomimetic hydroxyapatite nanocrystals are an active carrier for Salmonella bacteriophages [PDF]

, 2019
open access articlePurpose: The use of bacteriophages represents a valid alternative to conventional antimicrobial treatments, overcoming the widespread bacterial antibiotic resistance phenomenon.
Capparelli, Rosanna, Capuano, Federico, Contaldi, Felice, Della Ventura, Bartolomeo, Fulgione, Andrea, Giannini, Cinzia, Ianniello, Flora, Lelli, Marco, Papaianni, Marina, Pastore, Stella, Roveri, Norberto, Sgamma, Tiziana, Velotta, Raffaele   +12 more
core   +2 more sources

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

A novel tail fiber protein triggers phage DNA ejection by recognizing lipopolysaccharides of K54 hypervirulent Klebsiella pneumoniae

Microbiology Spectrum
Bacteriophage (phage) therapy is a promising alternative antibacterial approach for treating infectious diseases by hvKp. However, there has been a lack of studies on the host recognition and infection initiation of hvKp phages.
Ming Yin, Li Cao, Yu Fu, Yanjun Lu, Yi Yan, Lvxin Qian, Li Xiang, Tiejun Zhou, Huan Chen, Ying Li, Luhua Zhang   +10 more
doaj   +1 more source

Development Of An Engineered Bioluminescent Reporter Phage For Detection Of Bacterial Blight Of Crucifers [PDF]

, 2012
Bacterial blight, caused by the phytopathogen Pseudomonas cannabina pv. alisalensis, is an emerging disease afflicting important members of the Brassicaceae family.
Bull, Carolee T., Molineux, Ian J., Rubio, Isael, Schofield, David A., Wechter, W. Patrick, Westwater, Caroline   +5 more
core   +1 more source

Extreme Kinetic Stability and RNase Resistance of Human Telomerase RNA G‐Quadruplexes Overcome by DHX36 Helicase

Advanced Science, EarlyView.
The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo, Yashuo Zhang, Yingxian Qian, Huiying Zhan, Wenqiang Wu, Huijuan You   +5 more
wiley   +1 more source

Genome Sequence of Mycobacterium Phage Guppsters.

microPublication biology
Mycobacterium Phage Guppsters was isolated on Mycobacterium smegmatis mc 2 155, displays a siphovirus morphology, and possesses a 54,835 base pair genome. Based on gene content similarity, Guppsters is assigned to cluster F1. Unlike a majority of F1 phages, Guppsters does not encode mycobacteriophage mobile elements.
Alley, Emma K, Hill, Lexi C, Houglum, Mya E, Lamppa, Maggie R, Pack, Khailee K, Pageau, Hailey D, Prosen, Cale J, Richards, Kylie R, Royer, Kendra S, Slettedahl, Emily A, Strusz, Ian L, Wiita, Lydia A, Zeidler, Jillian C, Westholm, Daniel E   +13 more
openaire   +2 more sources

Combining Comprehensive Analysis of Off-Site Lambda Phage Integration with a CRISPR-Based Means of Characterizing Downstream Physiology

mBio, 2017
During its lysogenic life cycle, the phage genome is integrated into the host chromosome by site-specific recombination. In this report, we analyze lambda phage integration into noncanonical sites using next-generation sequencing and show that it ...
Yu Tanouchi, Markus W. Covert
doaj   +1 more source

Isolation and Characterization of Salmonella Jumbo-Phage pSal-SNUABM-04

Viruses, 2020
The increasing emergence of antimicrobial resistance has become a global issue. Therefore, many researchers have attempted to develop alternative antibiotics. One promising alternative is bacteriophage.
Jun Kwon, Sang Guen Kim, Hyoun Joong Kim, Sib Sankar Giri, Sang Wha Kim, Sung Bin Lee, Se Chang Park   +6 more
doaj   +1 more source