Results 111 to 120 of about 1,053,752 (301)

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

open access: yesAngewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar   +2 more
wiley   +2 more sources

Genome sequence of bacteriophage ΦAR29: a basis for integrative plasmid vectors [PDF]

open access: yes, 2005
The initial aim of this project was to characterise the integrative recombination mechanism of bacteriophage ΦAR29 , to provide a better understanding for development of the shuttle plasmid pBA as a site-specific Bacteroides integration vector.
Seet, Shawn Ginn Ming
core  

Genome sequence of the K139-like phage VcP032 originating from the Vibrio cholerae O1 El Tor Ogawa serotype [PDF]

open access: yes, 2016
Vibrio cholerae is the cause of large cholera outbreaks, especially in endemic regions with high poverty and inadequate sanitation. Here, we announce the complete genome sequence of the virulence-associated broad host range V.
Strauch, Eckhard   +2 more
core   +1 more source

Functional–Taxonomic Scaling Resolves Conflicting Average Genome Size Estimates Across Environmental Gradients

open access: yesAdvanced Science, EarlyView.
Based on genome size‐functional breadth theory, we introduce and validate a framework that adjudicates conflicting average genome size (AGS) estimates by testing which estimate yields a gap between scaled functional diversity and scaled taxonomic diversity that is consistent with the expected positive association between genome size and gene functional
Huanhuan Zhu   +8 more
wiley   +1 more source

Структурні та генетичні особливості літичного бактеріофага Lw1, нового представника псевдо Т-парних фагів

open access: yesФактори експериментальної еволюції організмів, 2015
Aims. Bacteriophages are diverse group of bacterial parasites which have complex, but insufficient systematics. RB43-related bacteriophages have a specific genome type that clearly distinguishes them from other T4-like viruses.
А. І. Кушкіна
doaj  

Self-assembly of Escherichia coli phage shock protein A

open access: yes, 2014
The Phage shock protein (Psp) response is an extracytoplasmic stress response. The central component of this system is PspA, a protein that mediates the physiological response to membrane stress.
Male, Abigail, Tavassoli, Ali
core   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

open access: yesAdvanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen   +5 more
wiley   +1 more source

A novel tail fiber protein triggers phage DNA ejection by recognizing lipopolysaccharides of K54 hypervirulent Klebsiella pneumoniae

open access: yesMicrobiology Spectrum
Bacteriophage (phage) therapy is a promising alternative antibacterial approach for treating infectious diseases by hvKp. However, there has been a lack of studies on the host recognition and infection initiation of hvKp phages.
Ming Yin   +10 more
doaj   +1 more source

Complete Genome of the Xanthomonas euvesicatoria Specific Bacteriophage KΦ1, Its Survival and Potential in Control of Pepper Bacterial Spot

open access: yesFrontiers in Microbiology, 2018
Xanthomonas euvesicatoria phage KΦ1, a member of Myoviridae family, was isolated from the rhizosphere of pepper plants showing symptoms of bacterial spot. The phage strain expressed antibacterial activity to all X.
Katarina Gašić   +5 more
doaj   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

open access: yesAdvanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang   +8 more
wiley   +1 more source

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