Results 51 to 60 of about 68,311 (200)

Copper Stress Response of Antibiotic‐Resistant and Copper‐Tolerant Enterococcus faecium and the Antibacterial Efficacy of Functionalized Copper Surfaces

Advanced Materials Interfaces, EarlyView.
This study examines how different laser‐patterned copper and brass surfaces, including copper coatings, affect the survival of vancomycin‐resistant Enterococcus faecium. Using microscopy and genome analysis, the results show that copper tolerance varies between strains and can increase after vancomycin exposure.
Franca Arndt, Katharina Siems, Stella Marie Timofeev, Philippe Baumann, Aisha Saddiqa Ahmed, Daniel Wyn Müller, Frank Mücklich, Aaron Haben, Ralf Kautenburger, Ronja Anton, Christoph Schaudinn, Michael Laue, Oliver Schwengers, Katharina Runzheimer, Rocío Arazo del Pino, Kyriaki Xanthopoulou, Paul G. Higgins, Stefan Leuko, Alessa Lalinka Boschert   +18 more
wiley   +1 more source

Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University

Scientific Reports
Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked the centennial of Felix d’Hérelle’s first publication on the clinical applications of phages.
Silvia Würstle, Alina Lee, Kaitlyn E. Kortright, Franziska Winzig, William An, Gail L. Stanley, Govindarajan Rajagopalan, Zach Harris, Ying Sun, Buqu Hu, Michael Blazanin, Maryam Hajfathalian, Paul L. Bollyky, Paul E. Turner, Jonathan L. Koff, Benjamin K. Chan   +15 more
doaj   +1 more source

Phage therapy minimally affects the water microbiota in an Atlantic salmon (Salmo salar) rearing system while still preventing infection [PDF]

, 2023
Alexander W. Fiedler, Madeleine S. Gundersen, Toan P. Vo, Eivind Almaas, Ôlav Vadstein, Ingrid Bakke   +5 more
openalex   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Phage vB_Ec_ZCEC14 to treat antibiotic-resistant Escherichia coli isolated from urinary tract infections

Virology Journal
Escherichia coli is a commensal bacterial species in the human gastrointestinal tract; however, it could be pathogenic and cause severe infections in intra and extra-intestinal sites. Uropathogenic E.
Nedaa M. Ismael, Mohamed Azzam, Mohamed Abdelmoteleb, Ayman El-Shibiny   +3 more
doaj   +1 more source

Molecular Evaluation of High Fluoroquinolone Resistant Genes in Endemic Cases of Shigellosis, Northeast Part of Karnataka, India

Annals of Global Health, 2017
ObjectivesShigellosis is an acute infection of the intestine caused by bacteria in the genus 'Shigella' and also an important cause of diarrhea in developing countries.
Prabhurajeshwar C, Pramod Desai, Kelmani Chandrakanth R   +2 more
doaj   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

The therapeutic potential of bacteriophages targeting gram-negative bacteria using Galleria mellonella infection model

BMC Microbiology, 2018
Background Phage therapy is the therapeutic use of bacteriophages to treat highly drug resistant bacterial infections. The current surge in bacteriophage therapy is motivated mainly because of the emergence of antibiotic-resistant bacteria in clinics ...
Prasanth Manohar, Ramesh Nachimuthu, Bruno S. Lopes   +2 more
doaj   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

The human phageome: niche-specific distribution of bacteriophages and their clinical implications

Applied and Environmental Microbiology
Bacteriophages (phages) play a crucial role in shaping the composition and diversity of the human microbiome across various body niches. Recent advancements in high-throughput sequencing technologies have enabled comprehensive analysis of the human ...
Izabela Rybicka, Zuzanna Kaźmierczak
doaj   +1 more source