Results 51 to 60 of about 4,551,719 (377)
A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections [PDF]
, 2016 Bacteriophage therapy is currently resurging as a potential complement/alternative to antibiotic treatment. However, preclinical evaluation lacks streamlined approaches.
Arabski, Michal +13 more
core +2 more sources
Antibiotics, 2021 Bronisława Brandla Fejgin was a Polish-born Jewish female physician. Among Fejgin’s numerous articles in the field of microbiology, her later work was almost entirely devoted to phage research.
Andrzej Grzybowski +4 more
doaj +1 more source
Synergistic Interaction Between Phage Therapy and Antibiotics Clears Pseudomonas Aeruginosa Infection in Endocarditis and Reduces Virulence. [PDF]
, 2017 Increasing antibiotic resistance warrants therapeutic alternatives. Here we investigated the efficacy of bacteriophage-therapy (phage) alone or combined with antibiotics against experimental endocarditis (EE) due to Pseudomonas aeruginosa, an archetype ...
Entenza, J.M. +7 more
core +1 more source
Diversity and function of phage encoded depolymerases [PDF]
, 2020 Bacteriophages of the Podoviridae family often exhibit so-called depolymerases as structural components of the virion. These enzymes appear as tail spike proteins (TSPs).
Fieseler, Lars +2 more
core +1 more source
Viruses, 2022 Validated methods for phage selection, host range expansion, and lytic activity determination are indispensable for maximizing phage therapy outcomes. In this review, we describe some relevant methods, highlighting their advantages and disadvantages, and
T. Glonti, J. Pirnay
semanticscholar +1 more source
Phage Cocktails and the Future of Phage Therapy
Future Microbiology, 2013 Viruses of bacteria, known as bacteriophages or phages, were discovered nearly 100 years ago. Their potential as antibacterial agents was appreciated almost immediately, with the first 'phage therapy' trials predating Fleming's discovery of penicillin by approximately a decade.
Stephen T. Abedon +3 more
openaire +3 more sources
The Potential of Phage Therapy in Sepsis [PDF]
Frontiers in Immunology, 2017 Sepsis remains a difficult clinical challenge, since our understanding of its immunopathology is incomplete and no efficacious treatment currently exists. Its earlier stage results from an uncontrolled inflammatory response to bacteria while in the later stage disturbed immune response with immunodeficiency syndrome develops.
Andrzej Górski +7 more
openaire +4 more sources
Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections
Antibiotics, 2021 Patients with chronic urinary and urogenital multidrug resistant bacterial infections received phage therapy (PT) using intravesical or intravesical and intravaginal phage administration.
Sławomir Letkiewicz +5 more
doaj +1 more source
The Safety and Efficacy of Phage Therapy: A Systematic Review of Clinical and Safety Trials
Antibiotics, 2022 Trials of phage therapy have not consistently reported efficacy. This contrasts with promising efficacy rates from a sizeable and compelling body of observational literature.
H. Stacey +2 more
semanticscholar +1 more source
Limitations of Phage Therapy and Corresponding Optimization Strategies: A Review
Molecules, 2022 Bacterial infectious diseases cause serious harm to human health. At present, antibiotics are the main drugs used in the treatment of bacterial infectious diseases, but the abuse of antibiotics has led to the rapid increase in drug-resistant bacteria and
Jiaxi Lin, Fangyuan Du, M. Long, Peng Li
semanticscholar +1 more source