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The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies
Viruses, 2021 Increasing rates of infection by antibiotic resistant bacteria have led to a resurgence of interest in bacteriophage (phage) therapy. Several phage therapy studies in animals and humans have been completed over the last two decades.
Dan Liu +9 more
semanticscholar +1 more source
Phage therapy and the public:Increasing awareness essential to widespread use [PDF]
, 2023 Today, the antimicrobial resistance (AMR) crisis is shaping a world where previously treatable infections can kill. This has revitalised the development of antibiotic alternatives, such as phage therapy. The therapeutic use of phages, viruses that infect
Banducci, Susan +3 more
core +1 more source
Phage Therapy in Gastrointestinal Diseases
Microorganisms, 2020 Gastrointestinal tract microbiota plays a key role in the regulation of the pathogenesis of several gastrointestinal diseases. In particular, the viral fraction, composed essentially of bacteriophages, influences homeostasis by exerting a selective pressure on the bacterial communities living in the tract.
Beatriz Gutiérrez, Pilar Domingo-Calap
openaire +3 more sources
Microorganisms, 2022 Escherichia coli (E. coli) is one of the most common pathogenic bacteria worldwide. Avian pathogenic E. coli (APEC) causes severe systemic disease in poultry (Colibacillosis), and accordingly, has an extreme risk to the poultry industry and public health
Fatma Abdelrahman +6 more
doaj +1 more source
Understanding Biofilm-Phage Interactions in Cystic Fibrosis Patients Using Mathematical Frameworks [PDF]
arXiv, 2023 When planktonic bacteria adhere together to a surface, they begin to form biofilms, or communities of bacteria. Biofilm formation in a host can be extremely problematic if left untreated, especially since antibiotics can be ineffective in treating the bacteria.
arxiv
Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates. [PDF]
, 2012 UnlabelledInvestigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial ...
Bowman, Charles +13 more
core +2 more sources
Reassessment of Historical Clinical Trials Supports the Effectiveness of Phage Therapy
Clinical Microbiology Reviews, 2022 Phage therapy has become a hot topic in medical research due to the increasing prevalence of antibiotic-resistant bacteria strains. In the treatment of bacterial infections, bacteriophages have several advantages over antibiotics, including strain ...
L. Marongiu +4 more
semanticscholar +1 more source
Phage Therapy in the Year 2035 [PDF]
Frontiers in Microbiology, 2020 The emergence of multidrug resistant bacteria in both community- and hospital-acquired infections is recognized as a major public health threat. Phage therapy is increasingly mediatized and researched as an additional tool for combatting antibiotic resistant infections.
openaire +4 more sources
Chromosomal DNA deletion confers phage resistance to Pseudomonas aeruginosa. [PDF]
, 2014 Bacteria develop a broad range of phage resistance mechanisms, such as prevention of phage adsorption and CRISPR/Cas system, to survive phage predation.
He, Xuesong +13 more
core +1 more source
Phage Therapy in the Era of Multidrug Resistance in Bacteria: A Systematic Review
International Journal of Molecular Sciences, 2022 Bacteriophages offer an alternative for the treatment of multidrug-resistant bacterial diseases as their mechanism of action differs from that of antibiotics.
C. Aranaga +3 more
semanticscholar +1 more source