Results 71 to 80 of about 68,311 (200)

Characterization and therapeutic potential of phage vB_Eco_ZCEC08 against multidrug-resistant uropathogenic Escherichia coli

BMC Microbiology
Background Urinary tract infections (UTIs) caused by antibiotic-resistant bacteria have become a significant public health concern. The increasing ineffectiveness of antibiotics has led to a renewed focus on investigating other strategies, such as ...
Assmaa H. Hussein, Salsabil Makky, Raghda Hager, Ian F. Connerton, Ayman El-Shibiny   +4 more
doaj   +1 more source

CRISPR‐DNA Polymerase Assisted Targeted Mutagenesis for Regulable Laboratory Evolution

Advanced Science, EarlyView.
This study develops an in vivo targeted mutagenesis system based on CRISPR‐guided bacteriophage T5 or T7 DNA polymerases. This system can enable all possible types of substitution mutations within an expanded mutagenesis window in Escherichia coli and exhibit application potential in different microorganisms, thus accelerating the evolution of ...
Shuaili Chen, Xiangdi Chen, Yifan Peng, Qinghua Li, Jingwen Zhou, Jianghua Li, Guocheng Du, Jian Chen, Guoqiang Zhang   +8 more
wiley   +1 more source

Conformational Quenching in an Engineered Lipocalin Protein Achieves High Affinity Binding to the Toxin Colchicine

Angewandte Chemie, EarlyView.
Specific high affinity recognition of colchicine by an engineered anticalin involves loop dynamics and conformational selection Abstract The engineered lipocalin Colchicalin binds the clinically relevant plant toxin colchicine with picomolar affinity.
Mark J. Bostock, Christopher Kolloff, Elena Jerschke, Sam Asami, Arne Skerra, Simon Olsson, Michael Sattler   +6 more
wiley   +2 more sources

Perspectives of Phage–Eukaryotic Cell Interactions to Control Epstein–Barr Virus Infections

Frontiers in Microbiology, 2018
Recently, leading medical journals emphasized the importance of further studies on the potential application of bacterial viruses (phages) for the treatment of antibiotics-resistant infections outlining the present status of the therapy and perspectives ...
Andrzej Górski, Andrzej Górski, Andrzej Górski, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Beata Weber-Dąbrowska, Natalia Bagińska, Jan Borysowski   +10 more
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Using millimeter‐waves for rapid detection of pathogenic bacteria in food based on bacteriophage

Engineering Reports, 2019
The accessibility of a rapid method for detection and identification of food‐borne pathogens is crucial for food industry worldwide. Antibiotic resistance bacteria (eg, E. coli) that can enter the food chain in different ways, can indeed survive on foods
Kamel S. Sultan, Tamer A. Ali, Nada A. Fahmy, Ayman El‐Shibiny   +3 more
doaj   +1 more source

The First Isolation and Molecular Characterization of Shiga Toxin-Producing Virulent Multi-Drug Resistant Atypical Enteropathogenic Escherichia coli O177 Serogroup From South African Cattle

Frontiers in Cellular and Infection Microbiology, 2019
Atypical enteropathogenic E. coli (aEPEC) is a group of diarrhoeagenic Escherichia coli with high diversity of serogroups, which lack the bundle-forming pili (BFP) and genes encoding for shiga toxins.
Peter Kotsoana Montso, Victor Mlambo, Collins Njie Ateba   +2 more
doaj   +1 more source

Dispersal and Survival of Flavobacterium psychrophilum PhagesIn Vivoin Rainbow Trout andIn Vitrounder Laboratory Conditions: Implications for Their Use in Phage Therapy [PDF]

, 2013
Lone Madsen, Sif K. Bertelsen, Inger Dalsgaard, Mathias Middelboe   +3 more
openalex   +1 more source

Exploring Mucin as Adjunct to Phage Therapy [PDF]

, 2021
Amanda Carroll‐Portillo, Henry C. Lin
openalex   +1 more source

T‐2 Toxin Exploits Gut‐Derived Staphylococcus Saprophyticus to Disrupt Hepatic Macrophage Homeostasis

Advanced Science, EarlyView.
T‐2 toxin promotes the proliferation of intestinal S. saprophyticus and facilitates its translocation to the liver in piglets and mice. The translocated bacteria trigger autophagy in Kupffer cells and recruit monocytes to the liver through the nucleotide‐binding oligomerization domain 2 (NOD2) signaling pathway, alongside the M1 polarization of hepatic
Yuanyuan Zhu, Liu Xu, Fangrui Guo, Jianyu Qu, Xiangyan Liu, Qiurong Xu, Jie Sheng, Jiangping Wang, Xiaohong Xie, Ruimin Ren, Chuan Zhou, Sisi Yan, Shuiping Liu, Zhihang Yuan, Rongfang Li, Jing Wu, Jine Yi, Yulong Yin, Lixin Wen, Ji Wang   +19 more
wiley   +1 more source