Results 81 to 90 of about 2,642,573 (281)

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Phage Therapy in the Year 2035 [PDF]

Frontiers in Microbiology, 2020
The emergence of multidrug resistant bacteria in both community- and hospital-acquired infections is recognized as a major public health threat. Phage therapy is increasingly mediatized and researched as an additional tool for combatting antibiotic resistant infections.
openaire   +3 more sources

Quantitative Models of Phage-Antibiotic Combination Therapy

, 2020
The spread of multidrug-resistant (MDR) bacteria is a global public health crisis. Bacteriophage therapy (or “phage therapy”) constitutes a potential alternative approach to treat MDR infections. However, the effective use of phage therapy may be limited
Chung Yin Leung, Paul E. Turner, Benjamin K. Chan, Rogelio A. Rodriguez-Gonzalez, Joshua S. Weitz   +4 more
core   +1 more source

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Camacho, F., Perez, E.M., Amin, N., Aguilar, A., David I. Stott, Talavera, A., Arturo Talavera, Raiza Martinez, Frank Camacho, Nevis Amin, Ela M. Perez, Larralde, O.G., Alicia Aguilar, Martinez, R., Osmany G. Larralde, Stott, D.I.   +15 more
core   +1 more source

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

Advanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu, Wanlin Chen, Ben Cristofori‐Armstrong, Theo Crawford, Kai‐En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt, Jennifer D. Naughton, Nicholas D. Condon, Åsa Andersson, Farhad Dehkhoda, Kirsten L. McMahon, Tabea Klasfauseweh, Ashvriya Thapa, Hue Tran, Poanna Tran, Sina Jami, Lotten Ragnarsson, Sebastian G. B. Furness, Jennifer R. Deuis, Brett M. Collins, Wai‐Hong Tham, Indira Prasadam, Irina Vetter, Mehdi Mobli   +27 more
wiley   +1 more source

When bacteriophages encounter macrophages during their journey through the human body

Frontiers in Cellular and Infection Microbiology
The increasing problem of antibiotic resistance is one of the most significant threats to global public health, contributing to higher mortality rates, prolonged hospitalizations, and rising healthcare costs.
Martyna Cieślik, Magdalena Gębicka, Michał Wójcicki, Andrzej Górski, Andrzej Górski, Ewa Jończyk-Matysiak   +5 more
doaj   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strain [PDF]

, 2018
Phage therapy is increasingly put forward as a “new” potential tool in the fight against antibiotic resistant infections. During the “Centennial Celebration of Bacteriophage Research” conference in Tbilisi, Georgia on 26–29 June 2017, an international ...
Malik, Danish J., Gregory Resch (3331788), Hazan, R., Resch, Grégory, Bob G. Blasdel (3161151), Pirnay, Jean-Paul, Bob G. Blasdel, Elene Kakabadze (7130003), Chanishvili, N., Almeida, Gabriel, Kakabadze, Elene, Blasdel, Bob G., Andrzej Gorski (7130000), Nina Chanishvili (109451), Thomas Rose, Jean-Paul Pirnay (280), Van Raemdonck, H., van Raemdonck, Hilde, Kakabadze, E., Gelman, D., Pirnay, J.P., Mašlaňová, I., Łobocka, Małgorzata, Grégory Resch, Gabriel Magno de Freitas Almeida, Resch, G., Gelman, Daniel, Almeida, GMF, Ivana Mašlaňová, Hilde Van Raemdonck (7130027), Alice Maestri, Christine Rohde, Malik, D.J., Debarbieux, L., Rohde, Christine, Makalatia, K., Almeida, Gabriel Magno de Freitas, Khatuna Makalatia (7130015), Maia Merabishvili (109440), Jean-Paul Pirnay, Isabelle Huys (702749), Huys, Isabelle, De Freitas Almeida, Gabriel, Rose, T., Dana Štveráková, Isabelle Huys, Huys, I., Rohde, C., Maestri, A., Nina Chanishvili, Merabishvili, M., Hilde Van Raemdonck, Maestri, Alice, Gilbert Verbeken (109442), Roman Pantucek, Štveráková, Dana, Chanishvili, Nina, Małgorzata Łobocka, Łobocka, M., Štveráková, D., Roman Pantucek (7130021), Górski, A., Verbeken, G., Gilbert Verbeken, Merabishvili, Maia, Raemdonck, Hilde Van, Blasdel, B.G., Danish Malik (1254321), Gabriel Magno de Freitas Almeida (7130012), Górski, Andrzej, Danish J. Malik, Laurent Debarbieux, Verbeken, Gilbert, Gabriel Almeida, Elene Kakabadze, Laurent Debarbieux (356004), Bob Blasdel, Malgorzata Lobocka (7130006), Malik, Danish, Ronen Hazan (210976), Hazan, Ronen, Rose, Thomas, Danish Malik, Mašlaňová, Ivana, Dana Stverakova (7130024), Pantucek, R., Daniel Gelman, Thomas Rose (265817), Makalatia, Khatuna, Maia Merabishvili, Daniel Gelman (4897354), Pantucek, Roman, Ronen Hazan, Alice Maestri (7130009), Christine Rohde (512854), Ivana Maslanova (7130018), Khatuna Makalatia, Blasdel, Bob, Debarbieux, Laurent, Andrzej Górski, Pantucek R, Łobocka M, Hazan R, Debarbieux L, Malik DJ, Górski A, Gelman D, Van Raemdonck H, Resch G, Mašlaňová I, Blasdel BG, Kakabadze E, Štveráková D, Maestri A, Rohde C, Almeida GMF, Chanishvili N, Verbeken G, Pirnay JP, Makalatia K, Rose T, Huys I, Merabishvili M   +122 more
core   +2 more sources

Can phage–antibiotic combinations overcome uropathogenic Escherichia coli regrowth? evidence from in vitro and in vivo models

Virology Journal
Phage therapy is currently gaining attention as a promising alternative for treating multi-drug resistant (MDR) bacterial infections, including urinary tract infections (UTIs).
Salsabil Makky, Assmaa H. Hussein, Amira A. Mohamed, Kareem Essam, Mona M. Agwa, Marwa M. Abd ElAziz, Ayman El-Shibiny   +6 more
doaj   +1 more source