Results 81 to 90 of about 68,311 (200)

Efficacy of phage vB_Ps_ZCPS13 in controlling Pan-drug-resistant Pseudomonas aeruginosa from urinary tract infections (UTIs) and eradicating biofilms from urinary catheters

Virology Journal
Background Pan-drug resistance (PDR) is a ticking time bomb, as it causes high human hospitalizations and mortality rates. For instance, Pseudomonas aeruginosa is associated with significant rates of urinary tract infections (UTIs) due to several reasons
Amira A. Mohamed, Emad M. El-Zayat, Ayman El-Shibiny   +2 more
doaj   +1 more source

“Phage Transplantation in Allotransplantation”: Possible Treatment in Graft-Versus-Host Disease?

Frontiers in Immunology, 2018
Graft-versus-host disease, both acute and chronic (aGvHD, cGvHD) remains a major complication in patients undergoing hematopoietic cell transplantation (HCT) and a significant therapeutic challenge, as many patients do not respond adequately to presently
Andrzej Górski, Andrzej Górski, Andrzej Górski, Ewa Jończyk-Matysiak, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Beata Weber-Dąbrowska, Jan Borysowski   +9 more
doaj   +1 more source

Distinct Phage‐Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes

Advanced Science, EarlyView.
Distinct enzymes including dCTP deaminases (Dcds), dTMP phosphatases (Dtms), and dTTP pyrophosphatases (Dtt) are found to be responsible for dU‐DNA biosynthesis in the phages PBS1, DSS3_VP1, and PhiR1‐37. Both PhiR1‐37‐derived and synthetic dU‐DNA are resistant to cleavage by restriction enzymes and Cas12a nuclease targeting dT‐containing sites.
Yating Li, Jason Tan, Yanqin Tu, Jingnan Wu, Zaifang Zhang, Yifeng Wei, Xinan Jiao, Yan Zhou   +7 more
wiley   +1 more source

In Vivo Emergence of Podovirus Resistance via tarS Mutation During Phage-Antibiotic Treatment of Experimental MSSA Endocarditis

Viruses
Phage therapy shows promise as an adjunct to antibiotics for treating Staphylococcus aureus infections. We previously reported a combined flucloxacillin/two-phage cocktail treatment selected for resistance to podovirus phage 66 in a rodent model of ...
Jérémy Cherbuin, Jonathan Save, Emma Osswald, Grégory Resch   +3 more
doaj   +1 more source

BRIGHT Enables High‐SNR Live‐Cell Imaging of Non‐Repetitive Sequences via Bivalent Fluorescent Nanobody‐Mediated Cascade‐Dependent Illumination

Advanced Science, EarlyView.
BRIGHT is a newly developed live‐cell imaging system that integrates cascade amplification with background denoising through the bivalent binding capability and antigen‐dependent stability of a bivalent fluorescent nanobody targeting ALFA peptides.
Lei Feng, Tao Huang, Yanxi Han, Meng Tian, Duo Wang, Zilong Mei, Yu Ma, Yingshuo Ma, Jinming Li, Rui Zhang   +9 more
wiley   +1 more source

Isolation and characterization of phages ΦZC2 and ΦZC3 against carbapenem-resistant Acinetobacter baumannii, and efficacy of ΦZC3 on A549 cells

Virology Journal
Background Acinetobacter baumannii is an opportunistic pathogen and a major causative agent of hospital-acquired infections. This pathogen can acquire various antibiotic resistance genes, including those conferring resistance to last-resort antibiotics ...
Kareem Essam, Azza G. Kamel, Bishoy Maher Zaki, Mohamed Elhadidy, Amal Ahmed Abdel Aziz, Aysam Fayed, Tamer Roshdy, Ayman El-Shibiny   +7 more
doaj   +1 more source

Dual Nature of Bacteriophages: Friends or Foes in Minimally Processed Food Products—A Comprehensive Review

Viruses
The increasing consumer demand for minimally processed foods (MPFs) has highlighted the need for innovative preservation methods that ensure both safety and quality.
Michał Wójcicki, Barbara Sokołowska, Andrzej Górski, Ewa Jończyk-Matysiak   +3 more
doaj   +1 more source

Emerging Nanozyme Strategies for Precision Breast Cancer Treatment

Advanced Science, EarlyView.
Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang, Zhaozhou Ren, Haibo Wang, Xing Yang, Yang Song, Jun Liao, Xiaoying Li   +6 more
wiley   +1 more source

Emerging applications of phage therapy and fecal virome transplantation for treatment of Clostridioides difficile infection: challenges and perspectives [PDF]

, 2023
Hamideh Raeisi, Maryam Noori, Masoumeh Azimirad, Seyed Reza Mohebbi, Hamid Asadzadeh Aghdaei, Abbas Yadegar, Mohammad Reza Zali   +6 more
openalex   +1 more source

Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems

Aggregate, EarlyView.
Schematic illustration of engineered RNA devices for in vivo targeted therapeutics via advanced delivery systems. ABSTRACT Engineered RNA devices can identify disease‐specific markers and precisely regulate gene expression, which is of great significance to the development of precision medicine.
Wei Luo, Xia Liu, Ying Han, Yijing Duan, Chuao Yu, Na Kong, Tian Xie   +6 more
wiley   +1 more source