Results 131 to 140 of about 40,342 (348)
Multi‐Targeting Non‐Specific Genome Engineering in Bacteria
Advanced Science, EarlyView.In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun +7 more
wiley +1 more source
Spread of multiresistant strains of Salmonella typhimurium phage types 204 and 193 in Britain. [PDF]
, 1978 E. J. Threlfall, L. R. Ward, B. Rowe
openalex +1 more source
Advanced Science, EarlyView.This study reveals circRSU1 with important oncogenic roles in hepatocellular carcinoma (HCC). CircRSU1, highly abundant in HCC, interacts with and stabilizes hnRNPA1 from ubiquitination and degradation. This stabilization facilitates hnRNPA1 binding to the internal ribosome entry site of HIF1A to increase HIF‐1α protein translation.
Shuting Xue +14 more
wiley +1 more source
Advanced Science, EarlyView.The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo +5 more
wiley +1 more source
Outbreak ofSalmonella enteritidisphage type 1B associated with frozen pre-cooked chicken cubes, Finland 2012 [PDF]
, 2017 Sari Huusko +8 more
openalex +1 more source
Advanced Science, EarlyView.Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan +17 more
wiley +1 more source
A report of the physiological, psychological, and bacteriological aspects of 20 days in full pressure suits, 20 days at 27,000 feet on 100 per cent oxygen, and 34 days of confinement, part III Final report, 2 Jun. 1964 - Nov. 1965 [PDF]
Physiological, psychological, and bacteriological aspects of 20 days in full pressure suits, 20 days at 27.000 feet on 100 percent oxygen, and 34 days of ...
Coburn, K. R.
core +1 more source
Use of Whole Genome Phylogeny and Comparisons in the Development of a Multiplex-PCR Assay to Identify Sequence Type 36 Vibrio parahaemolyticus [PDF]
, 2015 Vibrio parahaemolyticus sequence type (ST) 36 strains that are native to the Pacific Ocean have recently caused multi-state outbreaks of gastroenteritis linked to shellfish harvested from the Atlantic Ocean.
Cooper, Vaughn S. +6 more
core +1 more source
Advanced Science, EarlyView.This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe +5 more
wiley +2 more sources