Results 131 to 140 of about 74,832 (169)
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Nature, 1960
A MICRO-ORGANISM identified provisionally as Spirochaeta rosea nom. prov. has been isolated from a marine upper littoral rock-pool at Woods Hole, Mass. The filaments are spiral, 5–200µ long, 0.7µ wide, with a regular pitch of about 7µ and an amplitude of 2µ (Figs. 1 and 2). Transverse cell walls, approximately 2.5µ apart, are revealed by phase-contrast
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A MICRO-ORGANISM identified provisionally as Spirochaeta rosea nom. prov. has been isolated from a marine upper littoral rock-pool at Woods Hole, Mass. The filaments are spiral, 5–200µ long, 0.7µ wide, with a regular pitch of about 7µ and an amplitude of 2µ (Figs. 1 and 2). Transverse cell walls, approximately 2.5µ apart, are revealed by phase-contrast
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2007
The vast majority of novel DNA sequences deposited in the databases now comes from environmental phage DNA sequences. Methods are presented for the cloning and sequencing of phage DNA that might otherwise be lethal to bacterial host vectors or contain modified DNA bases that prevent standard cloning of such sequences. In addition, methods are presented
Veronica, Casas, Forest, Rohwer
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The vast majority of novel DNA sequences deposited in the databases now comes from environmental phage DNA sequences. Methods are presented for the cloning and sequencing of phage DNA that might otherwise be lethal to bacterial host vectors or contain modified DNA bases that prevent standard cloning of such sequences. In addition, methods are presented
Veronica, Casas, Forest, Rohwer
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Phage Choice, Isolation, and Preparation for Phage Therapy
Current Pharmaceutical Biotechnology, 2010Phage therapy is the use of bacteriophages--viruses that use bacteria as their host cells--as biocontrol agents of bacteria. Currently, phage therapy is garnering renewed interest as bacterial resistance to antibiotics becomes widespread. Historically, phage therapy was largely abandoned in the West in the 1940s due to the advent of chemical ...
Jason J, Gill, Paul, Hyman
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Phage DNA subunits in the phage precursor pool
Journal of Molecular Biology, 1961In the presence of chloramphenicol, phage precursor nucleic acid (DNA) can be allowed to accumulate to form a large intrabacterial pool, while protein synthesis has been temporarily arrested. Radiophosphorus, 32 P, of high specific activity was introduced at various stages and, by following the sensitivity to the radioactive 32 P decay of the final ...
A W, KOZINSKI, H, UCHIDA
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Models of phage growth and their applicability to phage therapy
Journal of Theoretical Biology, 2004Phage therapy is complicated by the self-replicating nature of phage. It is difficult to extrapolate from in vitro phage growth data to in vivo expectations, difficult to interpret in vivo data and difficult to generalize from one in vivo situation to another.
Richard J, Weld +2 more
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2016
Bacteriophages mediate horizontal gene transfer through a mechanism known as transduction. Phage transduction carried out in the laboratory involves a bacterial donor and a recipient, both of which are susceptible to infection by the phage of interest.
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Bacteriophages mediate horizontal gene transfer through a mechanism known as transduction. Phage transduction carried out in the laboratory involves a bacterial donor and a recipient, both of which are susceptible to infection by the phage of interest.
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Vibrio Phages and Phage-Typing
1992The first vibrio phages were identified by d’Herelle in 1926, and by the 1950s several distinct types of bacteriophage acting on V. cholerae had been described. These studies of cholera bacteriophages have been reviewed by Pollitzer.1 Most early studies were directed towards the use of cholera phages for treatment or prophylaxis rather than strain ...
B. Rowe, J. A. Frost
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Immunotechnology, 1995
Phage display is a powerful method for the selection and evolution of proteins and peptides. Applications include the generation of potent and novel antibodies, the in vitro improvement of protein affinity and function, epitope discovery, the development of leads for vaccine research and the identification of interacting proteins using cDNA libraries.
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Phage display is a powerful method for the selection and evolution of proteins and peptides. Applications include the generation of potent and novel antibodies, the in vitro improvement of protein affinity and function, epitope discovery, the development of leads for vaccine research and the identification of interacting proteins using cDNA libraries.
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Phage Vaccines and Phage Therapy
2011The application of combinatorial approaches in conjunction with phage display techniques might be critical for development of vaccines against various infective and cancer diseases. Phage technique allows the generation of novel immunogens representing structural/molecular mimics of pathogen-derived immunodominant epitopes, or protein domains displayed
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1996
Bacteriophage genomes encode lysozymes whose role is to favour the release of virions by lysis of the host cells or to facilitate infection. In this review, the evolutionary relationships between the phage lysozymes are described. They are grouped into several classes: the V-, the G-, the lambda- and the CH-type lysozymes.
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Bacteriophage genomes encode lysozymes whose role is to favour the release of virions by lysis of the host cells or to facilitate infection. In this review, the evolutionary relationships between the phage lysozymes are described. They are grouped into several classes: the V-, the G-, the lambda- and the CH-type lysozymes.
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