The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye
Nature Communications, 2020 Aberrant immune responses including reactive phagocytes are implicated in the etiology of age-related macular degeneration (AMD), a major cause of blindness in the elderly. The translocator protein (18 kDa) (TSPO) is described as a biomarker for reactive
Anne Wolf, Marc Herb, Michael Schramm
exaly +2 more sources
Neutrophils and macrophages: The main partners of phagocyte cell systems [PDF]
Frontiers in Immunology, 2012 Biological cellular systems are groups of cells sharing a set of characteristics, mainly key function and origin. Phagocytes are crucial in the host defense against microbial infection.
Manuel T. Silva +2 more
doaj +3 more sources
A Novel Stochastic Multi-Scale Model of Francisella tularensis Infection to Predict Risk of Infection in a Laboratory [PDF]
Frontiers in Microbiology, 2018 We present a multi-scale model of the within-phagocyte, within-host and population-level infection dynamics of Francisella tularensis, which extends the mechanistic one proposed by Wood et al. (2014). Our multi-scale model incorporates key aspects of the
Jonathan Carruthers +5 more
doaj +5 more sources
Unravelling mononuclear phagocyte heterogeneity [PDF]
Nature Reviews Immunology, 2010 When Ralph Steinman and Zanvil Cohn first described dendritic cells (DCs) in 1973 it took many years to convince the immunology community that these cells were truly distinct from macrophages. Almost four decades later, the DC is regarded as the key initiator of adaptive immune responses; however, distinguishing DCs from macrophages still leads to ...
Geissmann, Frédéric +4 more
openaire +4 more sources
Altered Dynamics of
mBio, 2013 An important first line of defense against Candida albicans infections is the killing of fungal cells by professional phagocytes of the innate immune system, such as polymorphonuclear cells (PMNs) and macrophages.
Fiona M. Rudkin +5 more
doaj +2 more sources
New insights into mononuclear phagocyte biology from the visual system
Nature Reviews Immunology, 2017 Daniel R Saban
exaly +2 more sources
Hyphal growth of phagocytosed fusarium oxysporum causes cell lysis and death of murine macrophages [PDF]
, 2014 Peer reviewedPublisher ...
Bain, Judith M +4 more
core +18 more sources
Frontiers in Immunology, 2021 Endogenous mechanisms underlying bacterial infection resolution are essential for the development of novel therapies for the treatment of inflammation caused by infection without unwanted side effects.
Feihong Liang +10 more
doaj +1 more source
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance While broad efforts toward getting an overview of immune cell and soluble factor alterations in COVID-19 are under way, a deep and comprehensive understanding of the mononuclear phagocyte system, including circulating progenitors, is still ...
Egle Kvedaraite +23 more
semanticscholar +1 more source
Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes
Frontiers in Immunology, 2021 The membrane attack complex (MAC) of the complement system and Perforin-1 are well characterized innate immune effectors. MAC is composed of C9 and other complement proteins that target the envelope of gram-negative bacteria.
Leidy C. Merselis +2 more
doaj +1 more source