Results 11 to 20 of about 129,184 (245)
Frontiers in Immunology, 2023 IntroductionBlood-feeding arthropods rely on robust cellular and humoral immunity to control pathogen invasion and replication. Tick hemocytes produce factors that can facilitate or suppress microbial infection and pathogenesis. Despite the importance of
Abdulsalam Adegoke +4 more
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Structure of human phagocyte NADPH oxidase in the resting state
bioRxiv, 2022 Phagocyte oxidase plays an essential role in the first line of host defense against pathogens. It oxidizes intracellular NADPH to reduce extracellular oxygen to produce superoxide anions for pathogen killing.
Rui Liu +7 more
semanticscholar +1 more source
Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions
Life, 2021 The clearance of apoptotic cells is known to be a critical step in maintaining tissue and organism homeostasis. This process is rapidly/promptly mediated by recruited or resident phagocytes. Phagocytes that engulf apoptotic cells have been closely linked
Minjoo Han +7 more
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Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19
Circulation Research, 2021 Supplemental Digital Content is available in the text. Rationale: Resolution mechanisms are central in both the maintenance of homeostasis and the return to catabasis following tissue injury and infections. Among the proresolving mediators, the essential
D. Koenis +14 more
semanticscholar +1 more source
The Delivery of Extracellular “Danger” Signals to Cytosolic Sensors in Phagocytes
Frontiers in Immunology, 2022 Phagocytes, such as macrophages and dendritic cells, possess the ability to ingest large quantities of exogenous material into membrane-bound endocytic organelles such as macropinosomes and phagosomes.
Gerone A. Gonzales +2 more
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Better Together: Current Insights Into Phagosome-Lysosome Fusion
Frontiers in Immunology, 2021 Following phagocytosis, the nascent phagosome undergoes maturation to become a phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill and digest engulfed microbes, cells, and debris.
Jenny A. Nguyen +3 more
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Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids
Frontiers in Endocrinology, 2021 Endogenous oxidized phospholipids are produced during tissue stress and are responsible for sustaining inflammatory responses in immune as well as non-immune cells.
M. di Gioia, I. Zanoni
semanticscholar +1 more source
AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke
Cell Reports, 2021 Summary: The sterile inflammation caused by damage-associated molecular patterns (DAMPs) worsens the prognosis following primary injury such as ischemic stroke. However, there are no effective treatments to regulate DAMPs.
Natsumi Maehara +8 more
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Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium
Theranostics, 2020 Rationale: Exosomes are emerging as a promising drug delivery carrier. However, rapid uptake of exosomes by the mononuclear phagocyte system (MPS) remains an obstacle for drug delivery into other targeted organs, including the heart. We hypothesized that
Z. Wan +9 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 How phagocytes find invading microorganisms and eliminate pathogenic ones from human bodies is a fundamental question in the study of infectious diseases.
Xuehua Xu, Miao Pan, Tian Jin
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