Results 231 to 240 of about 86,040 (309)

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Multimodal single cell analyses reveal gene networks of planarian stem cell differentiation. [PDF]

Nat Commun
Pérez-Posada A, García-Castro H, Emili E, Guixeras-Fontana A, Vanni V, Salamanca-Diaz D, Arias-Baldrich C, Frölich S, van Heeringen SJ, Cebrià F, Kenny N, Solana J.   +11 more
europepmc   +1 more source

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, EarlyView.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source

<i>Toxoplasma</i> effector GRA15-driven CCL5 secretion enhances brain parasite load through microvascular sequestration of phagocytes. [PDF]

mBio
Afanaseva E, Rodriguez ME, Barragan A.
europepmc   +1 more source

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

Resident phagocytes promote non-cell-autonomous fragmentation of apoptotic cells. [PDF]

Sci Adv
Santavanond JP, Atkin-Smith GK, Lozano-González I, Roncero-Carol J, Jiang L, Hodge AL, Ozkocak DC, Zhao K, Gray DHD, Herold MJ, Kueh AJ, Ryan GF, Tixeira R, Olson MF, Hulett MD, Baxter AA, Poon IKH, Hoijman E.   +17 more
europepmc   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

A role for DICAM⁺ mononuclear phagocytes in controlling neuroinflammation in multiple sclerosis. [PDF]

Front Immunol
von Essen MR, Hansen MM, El Mahdaoui S, Hvalkof VH, Hansen MB, Buhelt S, Sellebjerg F.   +6 more
europepmc   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

When bacteriophages encounter macrophages during their journey through the human body. [PDF]

Front Cell Infect Microbiol
Cieślik M, Gębicka M, Wójcicki M, Górski A, Jończyk-Matysiak E.   +4 more
europepmc   +1 more source