Results 241 to 250 of about 86,040 (309)

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

Hemozoin-induced immunomodulation and prostate carcinogenesis: mechanisms and implications. [PDF]

Front Oncol
Akinyosoye AD, Rotimi SO, Olasehinde OE, Oduselu GO, Oranusi SU, Akinnola OO.   +5 more
europepmc   +1 more source

A novel biomimetic liposome drug delivery system mediated by macrophage targeting for precision treatment of encephalitis

BMEMat, EarlyView.
An advanced macrophage‐mediated biomimetic liposome (AC‐LP@RAW) that can penetrate the BBB and precisely target inflammatory sites in the deep brain was established in this study based on the unique immune homing property of macrophages, and showed a significantly improved delivery of curcumin to the brain.
Mengru Wu, Baoqin Song, Zhihao Chen, Wenzhong Li, Wanjun Liang, Xiu Wang   +5 more
wiley   +1 more source

Adam9-deficient retinal pigment epithelium pseudopods maintain photoreceptor outer segment renewal despite subretinal space expansion. [PDF]

J Clin Invest
Lewis TR, Castillo CM, Phan S, Shores CR, Hayase KK, Kim KY, Ellisman MH, Alekseev O, Burns ME, Arshavsky VY.   +9 more
europepmc   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Homotypic interactions between SLAMF1 receptors on innate T cells and neutrophils regulate killing of fungi. [PDF]

PLoS Pathog
Lau LS, Lichtenberger S, Taira CL, Klein BS, Wüthrich M.   +4 more
europepmc   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Pneumolysin-dependent and independent non-canonical autophagy processes mediate host defense against pneumococcal infection. [PDF]

Autophagy
Michno BJ, Pooranachandran N, Smith TC, Faught E, Lipowská S, Fenton AK, Meijer AH, Prajsnar TK.   +7 more
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

A conserved enzymatic toolkit targeting host cell metabolism is associated with Cryptococcus neoformans intracellular survival in protozoal and mammalian phagocytic cells. [PDF]

PLoS Pathog
Dragotakes Q, Jacobs E, Gerbig G, Greengo S, Jedlicka A, Dziedzic A, Casadevall A.   +6 more
europepmc   +1 more source