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Phagocytosis: Our Current Understanding of a Universal Biological Process

Frontiers in Immunology, 2020
Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm in diameter, including microorganisms, foreign substances, and apoptotic cells.
Eileen Uribe-Querol, Carlos Rosales
doaj   +2 more sources

Phagocytosis in the Brain: Homeostasis and Disease

Frontiers in Immunology, 2019
Microglia are resident macrophages of the central nervous system and significantly contribute to overall brain function by participating in phagocytosis during development, homeostasis, and diseased states.
Dylan A. Galloway, Alexandra E. M. Phillips, David R. J. Owen, Craig S. Moore   +3 more
doaj   +2 more sources

Measurement of macrophage phagocytic capacity by quantifying maximum membrane extension using an opsonized capillary tube assay [PDF]

Scientific Reports
The zipper mechanism explains phagocytosis as sequential ligand–receptor interactions between macrophages and antigens, followed by the cell membrane extension for phagosome formation. Hence, the ability of macrophages to innate immunity is restricted by
Dan Horonushi, Souta Suzuki, Maiha Ando, Haruka Yuki, Kenji Yasuda   +4 more
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Emerging phagocytosis checkpoints in cancer immunotherapy

Signal Transduction and Targeted Therapy, 2023
Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as it utilizes patients’ own immune systems in combating the cancer cells.
Yue-Ying Liu, Yanjin Wang, Yanrong Yang, Linjun Weng, Qi Wu, Jin Zhang, Pengcheng Zhao, L. Fang, Yufeng Shi, Ping Wang   +9 more
semanticscholar   +1 more source

The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis

Glia, 2022
In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between demyelination and remyelination can trigger progressive degenerative processes.
M. K. Sen, D. Mahns, J. Coorssen, P. Shortland   +3 more
semanticscholar   +1 more source

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

Nature Communications, 2021
The role of microglia cells in Alzheimer’s disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4+) and non-containing (XO4 ...
Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F. Ouyang, Gui-zhi Sun, N. Croft, F. Rossello, R. Simmons, S. Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H Vandekolk, Zehra C. Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, M. Larcombe, J. Haynes, C. Mclean, Sarah Williams, S. Chai, Trevor Wilson, R. Lister, C. Pouton, A. Purcell, O. Rackham, E. Petretto, J. Polo   +27 more
semanticscholar   +1 more source

SeV C Protein Plays a Role in Restricting Macrophage Phagocytosis by Limiting the Generation of Intracellular Double-Stranded RNA

Frontiers in Microbiology, 2022
Macrophages play a central role in the innate immune response to respiratory viral infections through pro-inflammatory factor secretion and phagocytosis.
Naoko Morita, Yukie Tanaka, Kenji Takeuchi, Yoshinori Kitagawa, Ryusuke Sakuma, Naoki Koide, Takayuki Komatsu   +6 more
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Microglial phagocytosis of neurons in neurodegeneration, and its regulation

Journal of Neurochemistry, 2021
There is growing evidence that excessive microglial phagocytosis of neurons and synapses contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) studies have linked multiple phagocytic genes to neurodegenerative diseases ...
C. Butler, A. Popescu, Emily J. A. Kitchener, David H Allendorf, M. Puigdellívol, Guy C. Brown   +5 more
semanticscholar   +1 more source

In vitro analysis of anti-HPA-1a dependent platelet phagocytosis and its inhibition using a new whole blood phagocytosis assay (WHOPPA)

Frontiers in Immunology, 2023
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a serious bleeding condition mostly caused by the reaction between maternal anti-HPA-1a antibodies and fetal platelets. This reaction leads to Fc-dependent platelet phagocytosis.
Paula Ames, Nelli Baal, Martin Speckmann, Martin Speckmann, Gabriela Michel, Judith Ratke, Christina Klesser, Nina Cooper, Daisuke Takahashi, Behnaz Bayat, Gregor Bein, Sentot Santoso   +11 more
doaj   +1 more source

Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2

Cell Death and Differentiation, 2021
During cancer therapy, phagocytic clearance of dead cells plays a vital role in immune homeostasis. The nonapoptotic form of cell death, ferroptosis, exhibits extraordinary potential in tumor treatment.
Xiang Luo, Hai-Biao Gong, Hua-Ying Gao, Yan-Ping Wu, Wan-Yang Sun, Zhengixan Li, Guan Wang, Bo Liu, Lei Liang, H. Kurihara, Wen-Jun Duan, Yi-Fang Li, Rong-Rong He   +12 more
semanticscholar   +1 more source