Results 1 to 10 of about 435,710 (236)
Emerging phagocytosis checkpoints in cancer immunotherapy
Signal Transduction and Targeted Therapy, 2023 Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as it utilizes patients’ own immune systems in combating the cancer cells.
Qi Wu, Yufeng Shi
exaly +2 more sources
Phagocytosis: Our Current Understanding of a Universal Biological Process
Frontiers in Immunology, 2020 Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm in diameter, including microorganisms, foreign substances, and apoptotic cells.
Eileen Uribe-Querol, Carlos Rosales
doaj +2 more sources
Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance
Cancer Cell, 2021 Immunotherapy induces durable clinical responses in a fraction of patients with cancer. However, therapeutic resistance poses a major challenge to current immunotherapies.
Heng Lin, Ilona Kryczek, Michael D Green
exaly +2 more sources
Syk activation during FcγR-mediated phagocytosis involves Syk palmitoylation and desulfenylation [PDF]
Life Science AllianceUpon Fc gamma R–mediated phagocytosis, Syk is palmitoylated by DHHC5 and desulfenylated on nearby Cys residues, and both modifications are important for Syk phosphorylation and phagocytosis.
Maxime Jansen +4 more
doaj +2 more sources
Phagocytosis in the Brain: Homeostasis and Disease
Frontiers in Immunology, 2019 Microglia are resident macrophages of the central nervous system and significantly contribute to overall brain function by participating in phagocytosis during development, homeostasis, and diseased states.
Dylan A. Galloway +3 more
doaj +2 more sources
LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance
Cell, 2018 Targeting autophagy in cancer cells and in the tumor microenvironment are current goals of cancer therapy. However, components of canonical autophagy play roles in other biological processes, adding complexity to this goal.
Larissa D Cunha +2 more
exaly +2 more sources
Phagocytosis checkpoints as new targets for cancer immunotherapy
Nature Reviews Cancer, 2019 Mingye Feng, Wen Jiang, Betty Y S Kim
exaly +2 more sources
Current Biology, 2011 SummaryPhagocytosis is defined as the receptor-mediated engulfment of large (≥0.5 μm) particles into plasma membrane-derived vacuoles called phagosomes. Following scission from the plasma membrane, the phagosomes undergo a maturation process, sequentially fusing with endosomes and lysosomes, ultimately becoming phagolysosomes — highly acidic and ...
Botelho, Roberto J., Grinstein, Sergio
+5 more sources
Cell Reports, 2021 Summary: Blockade of the inhibitory checkpoint SIRPα-CD47 promotes phagocytosis of cancer cells by macrophages and is a promising avenue in anti-cancer therapy.
Zhenghai Tang +6 more
doaj +1 more source
Beyond autophagy: LC3-associated phagocytosis and endocytosis
Science Advances, 2022 Noncanonical functions of the autophagy machinery in pathways including LC3-associated phagocytosis and LC3-associated endocytosis have garnered increasing interest in both normal physiology and pathobiology.
C. Peña-Martínez +2 more
semanticscholar +1 more source