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Emerging phagocytosis checkpoints in cancer immunotherapy

Signal Transduction and Targeted Therapy, 2023
Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as it utilizes patients’ own immune systems in combating the cancer cells.
Qi Wu
exaly   +2 more sources

Phagocytosis: Our Current Understanding of a Universal Biological Process

Frontiers in Immunology, 2020
Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm in diameter, including microorganisms, foreign substances, and apoptotic cells.
Eileen Uribe-Querol, Carlos Rosales
doaj   +2 more sources

Phagocytosis in the Brain: Homeostasis and Disease

Frontiers in Immunology, 2019
Microglia are resident macrophages of the central nervous system and significantly contribute to overall brain function by participating in phagocytosis during development, homeostasis, and diseased states.
Dylan A. Galloway, Alexandra E. M. Phillips, David R. J. Owen, Craig S. Moore   +3 more
doaj   +2 more sources

Roles of the phagocytosis checkpoint in radiotherapy [PDF]

Cell Death and Disease
Radiotherapy is widely used in cancer treatment in both curative and palliative care due to its good safety profile and broad clinical availability.
Yulan Kui, Fan Tong, Ruiguang Zhang, Jian Wang, Xiaorong Dong   +4 more
doaj   +2 more sources

Evaluating antibody mediated opsonophagocytosis of bacteria via lab protocol: RAW 264.7 cell phagocytosis assay. [PDF]

PLoS ONE
Assessing the phagocytosis of microbes by macrophages is an important component of studies of novel immunotherapeutics, antimicrobial drugs, immune effectors, or any immunology related research.
Matthew Slarve, Travis Nielsen, Dongran Yu, Jordyn VanOrman, Brian Luna, Brad Spellberg   +5 more
doaj   +2 more sources

Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis

Nature, 2021
Daniel Fernandez, Jose A A Seoane, Katherine Liu   +2 more
exaly   +2 more sources

Phagocytosis checkpoints as new targets for cancer immunotherapy

Nature Reviews Cancer, 2019
Mingye Feng, Wen Jiang, Betty Y S Kim
exaly   +2 more sources

Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK [PDF]

, 2015
The GTPases belonging to the Rho family control the actin cytoskeleton rearrangements needed for particle internalization during phagocytosis. ROCK and mDia1 are downstream effectors of RhoA, a GTPase involved in that process.
A Alonso, A Schonichen, A Subtil, A Tierrez, A Yoneda, AB Hall, AB Jaffe, AD Hoppe, AL Bishop, AP Wheeler, AR Frampton Jr., AS Alberts, B Qualmann, BJ Wallar, C Capo, C Cougoule, C Yang, CA Burnham, CM Haglund, CW Gourlay, D Howe, D Michaelson, D Michaelson, D Truong, Daniel E. Voth, DE Voth, DJ Hackam, DM Underhill, DM Waag, DT Brandt, E Alix, E Caron, E Colucci-Guyon, E Lemichez, EJ van Schaik, EM Rosales, EN Firat-Karalar, F Li, F Matsumura, F Niedergang, G Kaplan, GD Fairn, H Bierne, H Bierne, H Genth, HJ Newton, IM Olazabal, J Dellacasagrande, J Faix, J Hanisch, J Pizarro-Cerda, J Pizarro-Cerda, JA McDonough, JA Swanson, JC Patel, JC Patel, JE Heindl, Jesús S. Distel, JG Duman, JG Kim, K Aktories, K Bhadriraju, L Hodgson, LA Allen, M Aguilera, M Amano, M Amano, M Fernandez-Borja, M Kaksonen, M Ladwein, María I. Colombo, MG Gutierrez, Milton O. Aguilera, ML Gardel, N Ramalingam, N Watanabe, N Watanabe, NA Khan, O Billker, O Pertz, O Pertz, OB Matas, OG Baca, OG Baca, P Aspenstrom, P Cossart, P Croise, P Hotulainen, PJ Roberts, PS Romano, R Fox, RA Carabeo, RC May, RC May, Rodolfo M. Ortiz Flores, Romina P. Salinas, RS Flannagan, S Meconi, SJ Heasman, SK Hussain, T Dubois, T Tominaga, V Benard, VC Tam, W Beron, Walter Berón, WI Goh, X Chi, XD Ren, Z Woldehiwet   +109 more
core   +20 more sources

Succinate Promotes Phagocytosis of Monocytes/Macrophages in Teleost Fish

Frontiers in Molecular Biosciences, 2021
Development of immunity-based strategy to manage bacterial infection is urgently needed in aquaculture due to the widespread of antibiotic-resistant bacteria.
Dai-xiao Yang, Dai-xiao Yang, Dai-xiao Yang, Hao Yang, Hao Yang, Hao Yang, Yun-chao Cao, Yun-chao Cao, Yun-chao Cao, Ming Jiang, Ming Jiang, Ming Jiang, Jun Zheng, Bo Peng, Bo Peng, Bo Peng   +15 more
doaj   +1 more source

The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis

Glia, 2022
In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between demyelination and remyelination can trigger progressive degenerative processes.
M. K. Sen, D. Mahns, J. Coorssen, P. Shortland   +3 more
semanticscholar   +1 more source