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Analysis of cellular responses of macrophages to zinc ions and zinc oxide nanoparticles: a combined targeted and proteomic approach [PDF]
Two different zinc oxide nanoparticles, as well as zinc ions, are used to study the cellular responses of the RAW 264 macrophage cell line. A proteomic screen is used to provide a wide view of the molecular effects of zinc, and the most prominent results are cross-validated by targeted studies.
arxiv +1 more source
High fat diet deviates PtC-specific B1 B cell phagocytosis in obese mice [PDF]
Phagocytosis had been attributed predominantly to "professional" phagocytes such as macrophages, which play critical roles in adipose tissue inflammation.
Allaimo, Danielle+8 more
core +1 more source
Expression of the Alpha8 Integrin Chain Facilitates Phagocytosis by Renal Mesangial Cells
Background/Aims: Healing of mesangioproliferative glomerulonephritis involves degradation of excess extracellular matrix, resolution of hypercellularity by apoptosis and phagocytosis of apoptotic cells. Integrin receptors participate in the regulation of
Ines Marek+7 more
doaj +1 more source
Phase field model for phagocytosis dynamics [PDF]
The basic process of the innate immune system when phagocyte (white blood cell) engulf or swallow a target particle (bacterium or dead cell), is called phagocytosis. We apply the phase field approach in the spirit of [1], that couples the order parameter $u$ with 3D polarization (orientation) vector field $\textbf{P}$ of the actin network of the ...
arxiv
Bigraphical models for protein and membrane interactions [PDF]
We present a bigraphical framework suited for modeling biological systems both at protein level and at membrane level. We characterize formally bigraphs corresponding to biologically meaningful systems, and bigraphic rewriting rules representing biologically admissible interactions.
arxiv +1 more source
The involvement of MiR-1-clathrin pathway in the regulation of phagocytosis.
Phagocytosis, one of the most powerful immune responses, is a complicated process regulated by many factors. However the regulation of phagocytosis mediated by microRNAs has not been extensively investigated.
Cuilian Liu, Jiajia Wang, Xiaobo Zhang
doaj +1 more source
Phagosome-lysosome fusion is a calcium-independent event in macrophages. [PDF]
Phagosome-lysosome membrane fusion is a highly regulated event that is essential for intracellular killing of microorganisms. Functionally, it represents a form of polarized regulated secretion, which is classically dependent on increases in ...
Ernst, JD+5 more
core +2 more sources
Background Tibolone is a synthetic steroid used in clinical practice for the treatment of climacteric symptoms and osteoporosis. Active metabolites of tibolone, generated in target tissues, have an affinity for estrogen and androgen receptors. Astrocytes
Andrea Crespo-Castrillo+2 more
doaj +1 more source
Reticulocalbin-1 facilitates microglial phagocytosis. [PDF]
Phagocytosis is critical to the clearance of apoptotic cells, cellular debris and deleterious metabolic products for tissue homeostasis. Phagocytosis ligands directly recognizing deleterious cargos are the key to defining the functional roles of ...
Ying Ding+8 more
doaj +1 more source
Research progress of astrocyte phagocytosis in Alzheimer′s disease [PDF]
Astrocytes are heavily activated in Alzheimer′s disease, engulfing damaged synapses, Aβ proteins, Tau proteins, apoptotic cells and other substrates. However, these substrates are difficult to degrade, accumulate as the disease progresses, and impair the
QIN Xiaoli, ZHAO Linna, FU Rong, GUO Yuying, XU Shixin
doaj +1 more source