Results 121 to 130 of about 13,993 (208)

The dual role of autophagy in suppressing and promoting hepatocellular carcinoma

Frontiers in Cell and Developmental Biology
The 5-year survival rate for hepatocellular carcinoma (HCC), a deadly form of liver cancer, is quite low. Although drug therapy is successful, patients with advanced liver cancer frequently develop resistance because of the significant phenotypic and ...
Wasnaa H. Mohammed, Ghassan M. Sulaiman, Mosleh M. Abomughaid, Daniel J. Klionsky, Mohammed H. Abu-Alghayth   +4 more
doaj   +1 more source

Arabidopsis CaLB1 undergoes phase separation with the ESCRT protein ALIX and modulates autophagosome maturation

Nature Communications
Autophagy is relevant for diverse processes in eukaryotic cells, making its regulation of fundamental importance. The formation and maturation of autophagosomes require a complex choreography of numerous factors.
Niccolò Mosesso, Niharika Savant Lerner, Tobias Bläske, Felix Groh, Shane Maguire, Marie Laura Niedermeier, Eliane Landwehr, Karin Vogel, Konstanze Meergans, Marie-Kristin Nagel, Malte Drescher, Florian Stengel, Karin Hauser, Erika Isono   +13 more
doaj   +1 more source

Decoding the function of Atg13 phosphorylation reveals a role of Atg11 in bulk autophagy initiation

EMBO Reports
Autophagy is initiated by the assembly of multiple autophagy-related proteins that form the phagophore assembly site where autophagosomes are formed. Atg13 is essential early in this process, and a hub of extensive phosphorylation.
Anuradha Bhattacharya, Raffaela Torggler, Wolfgang Reiter, Natalie Romanov, Mariya Licheva, Akif Ciftci, Muriel Mari, Lena Kolb, Dominik Kaiser, Fulvio Reggiori, Gustav Ammerer, David M Hollenstein, Claudine Kraft   +12 more
doaj   +1 more source

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

eLife, 2014
Formation of the autophagosome requires significant membrane input from cellular organelles. However, no direct evidence has been developed to link autophagic factors and the mobilization of membranes to generate the phagophore.
Liang Ge, Min Zhang, Randy Schekman
doaj   +1 more source

ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores

Cell Discovery
AbstractMacroautophagy is a process that cells engulf cytosolic materials by autophagosomes and deliver them to lysosomes for degradation. The biogenesis of autophagosomes requires ATG2 as a lipid transfer protein to transport lipids from existing membranes to phagophores. It is generally believed that endoplasmic reticulum is the main source for lipid
Bin Wei, Yuhui Fu, Xiuzhi Li, Fang Chen, Yiqing Zhang, Hanmo Chen, Mindan Tong, Linsen Li, Yi Pan, Shen Zhang, She Chen, Xiaoxia Liu, Qing Zhong   +12 more
openaire   +3 more sources

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. [PDF]

, 2008
Research in autophagy continues to accelerate,(1) and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring macroautophagy in different organisms.
Abeliovich, H., Agostinis, P., Agrawal, D.K., Aliev, G., Askew, D.S., Baba, M., Baehrecke, E.H., Bahr, B.A., Ballabio, A., Bamber, B.A., Bassham, D.C., Bergamini, E., Bi, X., Biard-Piechaczyk, M., Blum, J.S., Bredesen, D.E., Brodsky, J.L., Brumell, J.H., Brunk, U.T., Bursch, W., Camougrand, N., Cebollero, E., Cecconi, F., Chen, Y., Chin, L.S., Choi, A., Chu, C.T., Chung, J., Clarke, P.G.H, et, al., Klionsky, D.J.   +30 more
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PREP-modifikaatioiden vaikutus autofagiaan [PDF]

, 2017
Autophagy is a pathway for cells to degrade intracellular components that are no longer needed or are detrimental for the cells. It is essential for cell homeostasis and survival and has been related to various diseases and pathophysiology.
Huovila, Tiina
core  

The Aging Heart: Mitophagy at the Center of Rejuvenation. [PDF]

, 2020
Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular ...
Gustafsson, Åsa B, Liang, Wenjing J
core   +1 more source

Interactions Between Shigella flexneri and the Autophagy Machinery [PDF]

, 2016
Krokowski, S, Mostowy, S
core   +1 more source

Terminalia bellerica (baheda) inhibits protective autophagy and induces apoptosis in oral cancer cell lines [PDF]

, 2014
Cancer is a dreadful disease being one of the leading causes of death throughout the world. It has been estimated that about 8.2 million deaths in 2012 is caused by cancer only.
Padhi, P
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