Results 111 to 120 of about 11,851 (177)

Decoding the function of Atg13 phosphorylation reveals a role of Atg11 in bulk autophagy initiation

EMBO Reports
Autophagy is initiated by the assembly of multiple autophagy-related proteins that form the phagophore assembly site where autophagosomes are formed. Atg13 is essential early in this process, and a hub of extensive phosphorylation.
Anuradha Bhattacharya, Raffaela Torggler, Wolfgang Reiter, Natalie Romanov, Mariya Licheva, Akif Ciftci, Muriel Mari, Lena Kolb, Dominik Kaiser, Fulvio Reggiori, Gustav Ammerer, David M Hollenstein, Claudine Kraft   +12 more
doaj   +1 more source

Two specific interactions of GATE16 with TRPML3 and RAB33B regulate autophagy

Scientific Reports
ATG8s are essential for autophagy as they recruit various machinery to autophagic structures. We previously reported that the intracellular Ca2+ channel TRPML3 specifically interacts with the mammalian ATG8 homolog GATE16, but not LC3B to increase ...
Jiwoo Park, Areum Choi, Jin Kwon, Suzi Choi, Yun Min Park, Hyun Jin Kim   +5 more
doaj   +1 more source

Phagophore membrane connections and RAB24 in autophagy [PDF]

, 2015
Eukaryotic cells contain membrane-bound organelles to carry out specialized cellular functions. These organelles are inherited in cell division as templates and are augmented by proliferation through production of protein and lipid components by the cell,
Ylä-Anttila, Päivi
core  

The proppin Bcas3 and its interactor KinkyA localize to the early phagophore and regulate autophagy

, 2020
To resolve the signaling mechanisms that mediate the starvation-induced processes of Dictyostelium sporulation and encystation, we performed insertional mutagenesis on cells harboring an mRFP-tagged spore gene.
Pauline Schaap (629913), Yoko Yamada (335696)   +1 more
core   +1 more source

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex.

, 2018
Autophagy is an enigmatic cellular process in which double-membrane compartments, called "autophagosomes, form de novo adjacent to the endoplasmic reticulum (ER) and package cytoplasmic contents for delivery to lysosomes.
Otomo C, Ohashi K, Aebersold R, Chowdhury S, Lander GC, Leitner A, Otomo T   +6 more
core   +1 more source

Mechanisms of autophagosome formation

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
The formation of autophagosomes is a pivotal step in autophagy, a lysosomal degradation system that plays a crucial role in maintaining cellular homeostasis.
Yuko FUJIOKA, Nobuo N. NODA
doaj   +1 more source

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2AWIPI4 complex

, 2017
Autophagy is an enigmatic cellular process in which double-membrane compartments, called autophagosomes, form de novo adjacent to the endoplasmic reticulum (ER) and package cytoplasmic contents for delivery to lysosomes.
Ruedi Aebersold, Alexander Leitner, Gabriel C. Lander, Chinatsu Otomo, Kazuto Ohashi, Takanori Otomo, Saikat Chowdhury   +6 more
core   +1 more source

Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae

, 2010
The delivery of proteins and organelles to the vacuole by autophagy involves membrane rearrangements that result in the formation of large vesicles called autophagosomes.
Aniek Van Der Vaart, Janice Griffith, Benjamin S. Glick, Fulvio Reggiori   +3 more
core  

The Role of WIPI2, ATG16L1 and ATG12-ATG5 in Selective and Nonselective Autophagy

International audienceAutophagy is a conserved cellular recycling pathway that delivers damaged or superfluous cytoplasmic material to lysosomes for degradation.
Wollert, Thomas, Campisi, Daniele, Bonjour, Kennedy, Hawkins, N’toia   +3 more
core   +1 more source

Cutting edge: ESCRT-mediated phagophore closure in mammals. [PDF]

Biochem J
Takahashi Y, Opozda DM, Wang HG.
europepmc   +1 more source