Results 91 to 100 of about 13,993 (208)

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Atg23 and Atg27 Act at the Early Stages of Atg9 Trafficking in S. cerevisiae [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110581/1/tra12240 ...
Backues, Steven K., Bernard, Amélie, Cao, Yang, Klionsky, Daniel J., Orban, Daniel P., Singh, Kushal   +5 more
core   +1 more source

Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy [PDF]

Proceedings of the National Academy of Sciences, 2010
Macroautophagy (hereafter autophagy) is a ubiquitous process in eukaryotic cells that is integrally involved in various aspects of cellular and organismal physiology. The morphological hallmark of autophagy is the formation of double-membrane cytosolic vesicles, autophagosomes, which sequester cytoplasmic cargo and deliver it to the lysosome or vacuole.
Molly A, Lynch-Day, Deepali, Bhandari, Shekar, Menon, Ju, Huang, Huaqing, Cai, Clinton R, Bartholomew, John H, Brumell, Susan, Ferro-Novick, Daniel J, Klionsky   +8 more
openaire   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, Volume 16, Issue 5, Page 870-884, May 2026.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, Volume 16, Issue 5, Page 885-905, May 2026.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The Atg1–kinase complex tethers Atg9-vesicles to initiate autophagy

Nature Communications, 2016
Autophagosome biogenesis is initiated by recruitment of Atg9-vesicles to the phagophore assembly site. Here Rao et al. use a reconstituted in vitrosystem to describe the mechanism by which activation of the Atg1-kinase complex from its constituent parts ...
Yijian Rao, Marco G. Perna, Benjamin Hofmann, Viola Beier, Thomas Wollert   +4 more
doaj   +1 more source

Mitochondrial Fusion Machinery Specifically Involved in Energy Deprivation-Induced Autophagy

Frontiers in Cell and Developmental Biology, 2020
Mitochondria are highly dynamic organelles, which can form a network in cells through fusion, fission, and tubulation. Its morphology is closely related to the function of mitochondria. The damaged mitochondria can be removed by mitophagy.
Choufei Wu, Weijing Yao, Wenwen Kai, Weikang Liu, Wenlve Wang, Shuzhen Li, Yingcong Chen, Xiaoyong Wu, Liefeng Wang, Ying Li, Jingjing Tong, Jing Qian, Liqin Zhang, Zhi Hong, Zhi Hong, Cong Yi   +15 more
doaj   +1 more source

Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]

, 2017
The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core   +1 more source

Methods to Monitor and Quantify Autophagy in the Social Amoeba Dictyostelium discoideum [PDF]

, 2017
Autophagy is a eukaryotic catabolic pathway that degrades and recycles cellular components to maintain homeostasis. It can target protein aggregates, superfluous biomolecular complexes, dysfunctional and damaged organelles, as well as pathogenic ...
Cardenal-Muñoz, E., Coria, R., Domínguez-Martín, E., Escalante, R., King, J.S., Soldati, T.   +5 more
core   +3 more sources

Copper Overload Affects α‐Synuclein Clearance Mechanisms in a Parkinson's Disease In Vitro Model

Advanced Biology, Volume 10, Issue 5, May 2026.
This study reveals that copper overload disrupts neuronal protein clearance, leading to the accumulation of α‐synuclein and its phosphorylated form (p‐S129). By blocking autophagy and impairing the ubiquitin–proteasome system, copper promotes toxic aggregation in dopaminergic cells.
Debora Musarò, Marina Damato, Chiara Coppola, Marco Greco, Michele Maffia   +4 more
wiley   +1 more source