Results 71 to 80 of about 11,851 (177)

AMPK regulates phagophore-to-autophagosome maturation

Journal of Cell Biology
Barnaba, Broabent et al. develop K-FOCUS for high-throughput analysis of autophagy foci in human cells and demonstrate that glucose starvation downregulates autophagy via AMP-activated protein kinase, which prevents phagophore tethering to donor ...
C. Barnaba, David G. Broadbent, Emily G Kaminsky, Gloria I. Perez, J. C. Schmidt   +4 more
semanticscholar   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Atg4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

bioRxiv, 2020
The sequestration of damaged mitochondria within double-membrane structures termed autophagosomes is a key step of PINK1/Parkin mitophagy. The Atg4 family of proteases are thought to regulate autophagosome formation exclusively by processing the ...
T. Nguyen, B. Padman, Susanne Zellner, Grace Khuu, Louise Uoselis, Wai K. Lam, Marvin Skulsuppaisarn, Runa S. J. Lindblom, E. Watts, C. Behrends, M. Lazarou   +10 more
semanticscholar   +1 more source

The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore

Autophagy, 2021
MOAP1 (modulator of apoptosis 1) is a BAX-binding protein tightly regulated by the ubiquitin-proteasome system. Apoptotic stimuli stabilize MOAP1 protein and facilitate its interaction with BAX to promote apoptosis. Here we show that in contrast to being
Hao-Chun Chang, R. Tao, C. Tan, Ya-Jun Wu, B. Bay, Victor C. Yu   +5 more
semanticscholar   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

WIPI2b recruitment to phagophores and ATG16L1 binding are regulated by ULK1 phosphorylation

EMBO Reports
One of the key events in autophagy is the formation of a double-membrane phagophore, and many regulatory mechanisms underpinning this remain under investigation.
Andrea Gubas, Eleanor Attridge, Harold BJ Jefferies, Taki Nishimura, Minoo Razi, Simone Kunzelmann, Yuval Gilad, Thomas J Mercer, Michael M Wilson, Adi Kimchi, Sharon A Tooze   +10 more
doaj   +1 more source

Origin of the Autophagosomal Membrane in Plants

Frontiers in Plant Science, 2016
During autophagy, cargo molecules destined for degradation are sequestrated into a double membrane structure called autophagosome, which subsequently fuses with the vacuole.
Xiaohong Zhuang, Kin Pan CHUNG, Liwen Jiang, Liwen Jiang   +3 more
doaj   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system_Nguyen et al

, 2021
The sequestration of damaged mitochondria within double-membrane structures termed autophagosomes is a key step of PINK1/Parkin mitophagy. The ATG4 family of proteases are thought to regulate autophagosome formation exclusively by processing the ...
Nguyen, T
core   +2 more sources

Mitochondrial fission, integrity and completion of mitophagy require separable functions of Vps13D in Drosophila neurons.

PLoS Genetics, 2021
A healthy population of mitochondria, maintained by proper fission, fusion, and degradation, is critical for the long-term survival and function of neurons.
Ryan Insolera, Péter Lőrincz, Alec J Wishnie, Gábor Juhász, Catherine A Collins   +4 more
doaj   +1 more source