Results 61 to 70 of about 11,851 (177)

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

The ER - Glycogen Particle - Phagophore Triangle: A Hub Connecting Glycogenolysis and Glycophagy? [PDF]

, 2019
Glycogen particle is an intracellular organelle, which serves as a carbohydrate reserve in various cells. The function of glycogen is not entirely known in several cell types.
Bánhegyi, Gábor, Mandl, József
core   +1 more source

Physiological insights into ESCRT-mediated phagophore closure: potential cytoprotective roles for ATG8ylated membranes

Autophagy
The endosomal sorting complex required for transport (ESCRT) machinery is a membrane abscission system that mediates various intracellular membrane remodeling processes, including macroautophagy/autophagy.
Kouta Hamamoto, Xinwen Liang, David M Opozda, Hong-Gang Wang, Y. Takahashi   +4 more
semanticscholar   +1 more source

Systematic Analysis of Autophagy Identifies Atg9 Vesicles as the Origin of the Phagophore

bioRxiv, 2022
Autophagy is a catabolic pathway required for the clearance and recycling of cytoplasmic materials. Upregulation and dysfunction of autophagy contributes to the pathology of cancer and neurogenerative diseases, respectively.
David G. Broadbent, C. Barnaba, J. Schmidt   +2 more
semanticscholar   +1 more source

Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal, Christina Chan, S Patrick Walton   +2 more
wiley   +1 more source

Kinetics of Atg2-mediated lipid transfer from the ER can account for phagophore expansion

, 2020
The protein Atg2 has been proposed to form a membrane tether that mediates lipid transfer from the ER to the phagophore in autophagy. However, recent kinetic measurements on the human homolog ATG2A indicated a transport rate of only about one lipid per ...
Hummer, Gerhard, Bülow, Sören von
core   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Solution Structure of the Atg1 Complex: Implications for the Architecture of the Phagophore Assembly Site [PDF]

, 2015
SummaryThe biogenesis of autophagosomes commences at the phagophore assembly site (PAS), a protein-vesicle ultrastructure that is organized by the Atg1 complex.
Hummer, Gerhard, Lee, Il-Hyung, Köfinger, Jürgen, Ragusa, Michael J., Hurley, James H.   +4 more
core   +2 more sources

Membrane Contact Sites and Organelles Interaction in Plant Autophagy

Frontiers in Plant Science, 2020
Autophagy is an intracellular trafficking and degradation system for recycling of damaged organelles, mis-folded proteins and cytoplasmic constituents. Autophagy can be divided into non-selective autophagy and selective autophagy according to the cargo ...
Hao Ye, Changyang Ji, Rongfang Guo, Rongfang Guo, Liwen Jiang, Liwen Jiang   +5 more
doaj   +1 more source

Human erythroid differentiation requires VDAC1-mediated mitochondrial clearance

Haematologica, 2021
Erythroblast maturation in mammals is dependent on organelle clearance throughout terminal erythropoiesis. We studied the role of the outer mitochondrial membrane protein voltage-dependent anion channel-1 (VDAC1) in human terminal erythropoiesis.
Martina Moras, Claude Hattab, Pedro Gonzalez-Menendez, Claudio M. Fader, Michael Dussiot, Jerome Larghero, Caroline Le Van Kim, Sandrina Kinet, Naomi Taylor, Sophie D. Lefevre, Mariano A. Ostuni   +10 more
doaj   +1 more source