Results 81 to 90 of about 13,993 (208)

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Binding Features and Functions of ATG3

Frontiers in Cell and Developmental Biology, 2021
Autophagy is an evolutionarily conserved catabolic process that is essential for maintaining cellular, tissue, and organismal homeostasis. Autophagy-related (ATG) genes are indispensable for autophagosome formation.
Dongmei Fang, Huazhong Xie, Tao Hu, Hao Shan, Min Li   +4 more
doaj   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Origin of the Autophagosomal Membrane in Plants

Frontiers in Plant Science, 2016
During autophagy, cargo molecules destined for degradation are sequestrated into a double membrane structure called autophagosome, which subsequently fuses with the vacuole.
Xiaohong Zhuang, Kin Pan CHUNG, Liwen Jiang, Liwen Jiang   +3 more
doaj   +1 more source

Mitochondrial fission, integrity and completion of mitophagy require separable functions of Vps13D in Drosophila neurons.

PLoS Genetics, 2021
A healthy population of mitochondria, maintained by proper fission, fusion, and degradation, is critical for the long-term survival and function of neurons.
Ryan Insolera, Péter Lőrincz, Alec J Wishnie, Gábor Juhász, Catherine A Collins   +4 more
doaj   +1 more source

Indirect estimation of the area density of Atg8 on the phagophore [PDF]

Autophagy, 2009
Atg8 is a ubiquitin-like protein that controls the expansion of the phagophore during autophagosome formation. It is recruited to the phagophore during the expansion stage and released upon the completion of the autophagosome. One possible model explaining the function of Atg8 is that it acts as an adaptor of a coat complex.
Zhiping, Xie, Usha, Nair, Jiefei, Geng, Maciej B, Szefler, Edward D, Rothman, Daniel J, Klionsky   +5 more
openaire   +2 more sources

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

WIPI2b recruitment to phagophores and ATG16L1 binding are regulated by ULK1 phosphorylation

EMBO Reports
One of the key events in autophagy is the formation of a double-membrane phagophore, and many regulatory mechanisms underpinning this remain under investigation.
Andrea Gubas, Eleanor Attridge, Harold BJ Jefferies, Taki Nishimura, Minoo Razi, Simone Kunzelmann, Yuval Gilad, Thomas J Mercer, Michael M Wilson, Adi Kimchi, Sharon A Tooze   +10 more
doaj   +1 more source

Ubiquitin Modification of SARS-CoV-2 Membrane Protein Promotes Virion Assembly and Budding via Autophagy

Autophagy Reports, 2022
In our recent study, we reported the molecular mechanisms of SARS-CoV-2 assembly and budding. Envelope protein (E) and membrane protein (M) of SARS-CoV-2 form complexes that ensure the uniform size of viral particles for viral maturation and budding. The
Zhen Yuan, Binbin Ding
doaj   +1 more source

iLIR : a web resource for prediction of Atg8-family interacting proteins [PDF]

, 2014
Macroautophagy was initially considered to be a nonselective process for bulk breakdown of cytosolic material. However, recent evidence points toward a selective mode of autophagy mediated by the so-called selective autophagy receptors (SARs).
Johansen, Terje, Kalvari, Ioanna, Mulakkal, Nitha Charles, Nezis, I. P., Osgood, Richard, Promponas, Vasilis J., Tsompanis, Stelios   +6 more
core   +1 more source