Results 81 to 90 of about 11,851 (177)
MedComm, Volume 7, Issue 10, October 2026.Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna +3 more
wiley +1 more source
, 2011 Canonical autophagy is positively regulated by the Beclin 1/phosphatidylinositol 3-kinase class III (PtdIns3KC3) complex that generates an essential phospholipid, phosphatidylinositol 3-phosphate (PtdIns(3)P), for the formation of autophagosomes ...
Mauthe, Mario +13 more
core +1 more source
Autophagy Reports, 2022 In our recent study, we reported the molecular mechanisms of SARS-CoV-2 assembly and budding. Envelope protein (E) and membrane protein (M) of SARS-CoV-2 form complexes that ensure the uniform size of viral particles for viral maturation and budding. The
Zhen Yuan, Binbin Ding
doaj +1 more source
Posttranslational Modifications of p62/SQSTM1 in Health and Disease
MedComm, Volume 7, Issue 10, October 2026.Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang +8 more
wiley +1 more source
The Atg1–kinase complex tethers Atg9-vesicles to initiate autophagy
Nature Communications, 2016 Autophagosome biogenesis is initiated by recruitment of Atg9-vesicles to the phagophore assembly site. Here Rao et al. use a reconstituted in vitrosystem to describe the mechanism by which activation of the Atg1-kinase complex from its constituent parts ...
Yijian Rao +4 more
doaj +1 more source
Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions
MedComm, Volume 7, Issue 10, October 2026.Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley +1 more source
Elucidating Phagophore Nucleation in the Autophagy Pathway of Saccharomyces cerevisiae
, 2023 This dissertation focuses on a ubiquitous intracellular degradation pathway, macroautophagy/autophagy. More specifically, I detail my contribution to the understanding of Atg9 trafficking in yeast, where the essential autophagy protein, Atg9, is ...
Hawkins, Wayne
core +1 more source
AutophagyMacroautophagy/autophagy is a conserved pathway allowing the cell to clear and recycle unwanted materials. While decades of research have revealed molecular players and their hierarchical relationships in autophagy, the detailed mechanism by which these ...
Ge Yu, D. Klionsky
semanticscholar +1 more source
Synaptic Proteostasis in Health and Disease
Journal of Neurochemistry, Volume 170, Issue 10, October 2026.The localised creation and degradation of proteins at the pre and postsynaptic terminal are processes that are crucial for neuronal homeostasis. Synaptic proteostasis pathways are frequently reported as dysregulated in neurodevelopmental and neurodegenerative disorders.
Paul G. Donlin‐Asp, Emma L. Clayton
wiley +1 more source
Additional examples of mitophagy intermediates from EM analysis of Vps13D depleted neurons.
, 2021 A) Two examples of larval neurons expressing Vps13D-RNAi which contain mitochondria engaged with a phagophore. In the lower magnification images on the left side, mitochondria (M) that are not engaged with a phagophore have compact and electron dense ...
Gábor Juhász (752374) +4 more
core +1 more source