Results 101 to 110 of about 13,993 (208)

ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation

Cell Reports, 2018
Summary: Unc-51-like-kinase 1 (ULK1) is a target of both the mechanistic target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK), whose role is to facilitate the initiation of autophagy in response to starvation.
Ki Eun Pyo, Chang Rok Kim, Minkyoung Lee, Jong-Seo Kim, Keun Il Kim, Sung Hee Baek   +5 more
doaj   +1 more source

Host-pathogen interactions and subversion of autophagy [PDF]

, 2017
Macroautophagy (“autophagy”), is the process by which cells can form a double membraned vesicle that encapsulates material to be degraded by the lysosome.
Alemu, Ali, Axe, Barnett, Baxt, Beale, Birmingham, Campbell, Cao, Case, Choy, David G. McEwan, de Jong, Diao, Dortet, Gaillard, Ganley, Gannage, Genau, Gutierrez, Habisov, Hailey, Hamasaki, Hanada, Hegedus, Horenkamp, Huett, Ikeda, Ikeda, Itakura, Jacomin, James T. Murray, Jennings, Joachim, Jon D. Lane, Khaminets, Kim, Kirisako, Kirkin, Kraft, Kreibich, Krick, Kuma, Kwon, Kyei, Lety, Li, Liu, Liu, Lu, Lystad, Maejima, Manzanillo, Matsunaga, Matsunaga, McEwan, Mira, Mohrluder, Moreau, Mostowy, Nakagawa, Nakatogawa, Newman, Noad, Noda, Noda, Novak, Ogawa, Olsvik, Pankiv, Pankiv, Petkova, Polson, Popovic, Ravikumar, Richetta, Rogov, Rogov, Russell, Schnaith, Slobodkin, Stolz, Taguchi-Atarashi, Takats, Thurston, Thurston, Thurston, Tsuboyama, Tumbarello, van der Vaart, van Wijk, van Wijk, Verlhac, Viktor I. Korolchuk, von Muhlinen, Watson, Weidberg, Wild, Yang, Yang, Yoshikawa, Yu, Zheng, Zhong, Zhou   +104 more
core   +2 more sources

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

A conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast

Nature Communications, 2023
Organelles are shaped by curvature-generating proteins, which include the reticulons and REEPs that are involved in forming the endoplasmic reticulum (ER).
Ning Wang, Yoko Shibata, Joao A. Paulo, Steven P. Gygi, Tom A. Rapoport   +4 more
doaj   +1 more source

ATG16L1 induces the formation of phagophore-like membrane cups

Nature Structural & Molecular Biology
The hallmark of non-selective autophagy is the formation of cup-shaped phagophores that capture bulk cytoplasm. The process is accompanied by the conjugation of LC3B to phagophores by an E3 ligase complex comprising ATG12-ATG5 and ATG16L1. Here we combined two complementary reconstitution approaches to reveal the function of LC3B and its ligase complex
Mohan, Jagan, Moparthi, Satish, Girard-Blanc, Christine, Campisi, Daniele, Blanchard, Stéphane, Nugues, Charlotte, Rama, Sowmya, Salles, Audrey, Pénard, Esthel, Vassilopoulos, Stéphane, Wollert, Thomas   +10 more
openaire   +2 more sources

Structural and functional insights into TBC1D17 highlight the importance of the previously uncharacterized Rab‐binding domain

Protein Science, Volume 35, Issue 5, May 2026.
Abstract TBC (Tre2/Bub2/Cdc16) domain‐containing proteins constitute the widespread family of GTPase‐activating proteins (GAPs). They interact with the Rab superfamily of small GTPases, stimulate GTP hydrolysis, and regulate vesicle trafficking. TBC1D17, involved in Shiga toxin trafficking, autophagy and glucose metabolism regulation, constitutes an ...
Dominika Nielipińska, Marta Orlikowska, Maciej Nielipiński, Bartosz Sekuła, Katarzyna M. Błażewska, Edyta Gendaszewska‐Darmach, Agnieszka J. Pietrzyk‐Brzezińska   +6 more
wiley   +1 more source

Inferring Gene Regulatory Network Architecture Underlying Complex Traits: An Integrative Analysis of Mutant Lifespan and Gene Expression Profiles Identifies Master Regulators and Key Functional Modules for Yeast Aging

Aging Cell, Volume 25, Issue 5, May 2026.
We developed a LASSO‐based approach to uncover a three‐layered “fan‐in fan‐out” network architecture for complex traits like yeast aging, showing that peripheral genes influence lifespan indirectly through master regulators, which converge on core functional modules (e.g., stress response, autophagy).
Meng Ma, Juan Long, Yuting Chen, Yanqiu Shao, Man Zhu, Jiashun Zheng, Lu Yang, Yin Xiao, Matt Kaeberlein, Brian K. Kennedy, Yi Zheng, Hao Li, Jing Yang   +12 more
wiley   +1 more source

Progress in the study of autophagy-related proteins affecting resistance to chemotherapeutic drugs in leukemia

Frontiers in Cell and Developmental Biology
Leukemia is a life-threatening malignant tumor of the hematopoietic system. Currently, the main treatment modalities are chemotherapy and hematopoietic stem cell transplantation. However, increased drug resistance due to decreased sensitivity of leukemia
Meng Li, Jing Li, Shiming Zhang, Linghan Zhou, Yuanyuan Zhu, Shen Li, Qiong Li, Junjie Wang, Ruipeng Song   +8 more
doaj   +1 more source

Under the ROS…thiol network is the principal suspect for autophagy commitment. [PDF]

, 2010
Low molecular weight and protein sulphydryls undergo reactive oxygen species (ROS)-mediated oxidation. However, in contrast to the irreversible damages that oxidative conditions yield on biomolecules, the oxidation of reactive cysteines frequently ...
Cardaci, S, Ciriolo, MR, Desideri, E, Filomeni, G, Rotilio, G   +4 more
core   +1 more source

The Roles of Alix and VPS4A in Autophagy and Endosomal Pathways and Their Relation to HBV Replication

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Alix and VPS4A function in HBV biogenesis and degradation in the context of the endosomal and autophagic pathways. Alix and VPS4A orchestrate HBV secretion and degradation via endosomal and autophagic pathways. Under normal conditions, ESCRT ensures efficient virion budding and MVB formation.
Jia Li, Thekla Kemper, Shuping Tong, Xueyue Wang, Yong Lin, Mengji Lu   +5 more
wiley   +1 more source