Results 101 to 110 of about 11,851 (177)
LC3B Labeling on Terrestrial Isopod Adipocytes
Bio-Protocol, 2013 The LC3B protein plays a critical role in autophagy. Normally, this protein resides in the cytosol, but following cleavage and lipidation with phosphatidylethanolamine, LC3B associates with the phagophore.
Christine Braquart-Varnier +2 more
doaj +1 more source
VPS37A directs ESCRT recruitment for phagophore closure
Journal of Cell Biology, 2019 Takahashi et al. perform a genome-wide CRISPR screen using the HaloTag-LC3 assay to gain insight into the mechanisms of phagophore closure. They identify a role for VPS37A in coordinating the ESCRT assembly on the phagophore for membrane closure.
Yoshinori Takahashi +11 more
semanticscholar +1 more source
, 2017 Hosts utilize macroautophagy/autophagy to clear invading bacteria; however, bacteria have also developed a specific mechanism to survive by manipulating the host cell autophagy mechanism.
Leehyeon Kim (3354770) +12 more
core +1 more source
, 2016 Macroautophagy is primarily a degradative process that cells use to break down their own components to recycle macromolecules and provide energy under stress conditions, and defects in macroautophagy lead to a wide range of diseases. Atg9, conserved from
Yuchen Feng (2592829) +5 more
core +1 more source
In situ visualization of autophagy suggests vesicle fusion can contribute to phagophore expansion
bioRxivThe autophagy core machinery mediates the enclosure of cytosolic cargo destined for degradation in the lysosome. The Atg9-Atg2-Atg18 complex coordinates phagophore expansion via directed lipid transfer until closure of the phagophore rim.
Claire Ortmann de Percin Northumberland +8 more
semanticscholar +1 more source
In situ visualization of autophagy reveals the presence of vesicles at the expanding phagophore rim.
Journal of Cell ScienceThe autophagy core machinery mediates the enclosure of cytosolic cargo destined for degradation in the lysosome. The Atg9-Atg2-Atg18 complex coordinates phagophore expansion via directed lipid transfer until closure of the phagophore rim.
Claire Ortmann de Percin Northumberland +8 more
semanticscholar +1 more source
The dual role of autophagy in suppressing and promoting hepatocellular carcinoma
Frontiers in Cell and Developmental BiologyThe 5-year survival rate for hepatocellular carcinoma (HCC), a deadly form of liver cancer, is quite low. Although drug therapy is successful, patients with advanced liver cancer frequently develop resistance because of the significant phenotypic and ...
Wasnaa H. Mohammed +4 more
doaj +1 more source
The molecular organization of the phagophore assembly site [PDF]
, 2012 Autophagy is a degradative pathway crucial for multiple cellular processes and it is implicated in numerous diseases. Despite great efforts being made to understand the fundamental aspects of this pathway, many questions still remain unanswered.
Rieter, E.M.
core +1 more source
Nature CommunicationsAutophagy is relevant for diverse processes in eukaryotic cells, making its regulation of fundamental importance. The formation and maturation of autophagosomes require a complex choreography of numerous factors.
Niccolò Mosesso +13 more
doaj +1 more source
ATG9A-dependent, LC3-independent autophagy curbs the immune system to protect against disease
Autophagy ReportsSelective autophagy is generally believed to require the conjugation of microtubule associated protein 1 light chain 3 (LC3) proteins (or other autophagy-related 8 [ATG8] family members) on the inner phagophore leaflet to enable the recruitment of cargo ...
Dario Priem, Mathieu JM Bertrand
doaj +1 more source