Results 41 to 50 of about 11,851 (177)
The role of selenium on autophagy
JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2022 Selenium (Se) deficiency is associated with certain abnormalities, such as Keshan disease, cancer, cardiovascular disease (CVD), viral infections, infertility, immune system abnormalities, metabolic diseases, neurological disorders, and growth ...
Febriana Kurniasari +5 more
doaj +1 more source
Investigating the regulation of WIPI2b function at the phagophore by phosphorylation in starvation-induced autophagy [PDF]
, 2018 Macroautophagy, here referred to as autophagy, is an intracellular degradation pathway cells use to maintain their homeostasis. Autophagy is also required for cell survival during nutrient deprivation, as well as development and immunity in higher ...
Gubas, Andrea
core +1 more source
Autophagy Reports, 2023 There are two types of autophagy, non-selective (bulk) autophagy, in which substrates are randomly incorporated into autophagosomes, and selective autophagy, in which substrates are specifically targeted.
Takashi Kikuma, Joichiro Nishio
doaj +1 more source
COPII vesicles and the expansion of the phagophore
eLife, 2019 A new study has identified the proteins that adapt COPII vesicles to the needs of starving cells.
Catherine Rabouille
doaj +1 more source
Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore
bioRxiv, 2023 The covalent attachment of ubiquitin-like LC3 proteins prepares the autophagic membrane for cargo recruitment. We resolve key steps in LC3 lipidation by combining molecular dynamics simulations and experiments in vitro and in cellulo.
Shanlin Rao +6 more
semanticscholar +1 more source
Recent Advances in Membrane Shaping for Plant Autophagosome Biogenesis
Frontiers in Plant Science, 2020 Autophagy is an intracellular degradation process, which is highly conserved in eukaryotes. During this process, unwanted cytosolic constituents are sequestered and delivered into the vacuole/lysosome by a double-membrane organelle known as an ...
Cheuk-Ling Wun +2 more
doaj +1 more source
Ultrastructural relationship of the phagophore with surrounding organelles
, 2015 Phagophore nucleates from a subdomain of the endoplasmic reticulum (ER) termed the omegasome and also makes contact with other organelles such as mitochondria, Golgi complex, plasma membrane and recycling endosomes during its formation.
Joanna Biazik (728254) +4 more
core +1 more source
Atg21 restricts Atg8 lipidation to a novel vacuole-phagophore contact site [PDF]
, 2019 Macroautophagy is a degradative membrane trafficking pathway that removes and recycles cellular components to maintain cellular homeostasis. Targets for degradation are a variety of cytosolic components including protein aggregates, damaged or ...
Munzel, Lena
core +1 more source
Assays to Monitor Autophagy Progression in Cell Cultures
Cells, 2017 The vast number of implications of autophagy in multiple areas of life sciences and medicine has attracted the interest of numerous scientists that aim to unveil the role of this process in specific physiological and pathological contexts.
Idil Orhon, Fulvio Reggiori
doaj +1 more source
The Rod-Shaped ATG2A-WIPI4 Complex Tethers Membranes In Vitro
Contact, 2018 The autophagosome precursor membrane, termed the isolation membrane or phagophore , emerges adjacent to a phosphatidylinositol 3-phosphate (PI3P)-enriched transient subdomain of the endoplasmic reticulum called the omegasome , thereafter expanding to ...
Takanori Otomo +2 more
doaj +1 more source