Results 21 to 30 of about 11,851 (177)
Phagophore-lysosome/vacuole fusion in mutant yeast and mammalian cells
Autophagy, 2023 Macroautophagy/autophagy is a process through which the phagophores engulf non-essential or damaged cellular materials, forming double-membrane autophagosomes (APs) and fusing with lysosomes/vacuoles, after which the materials are degraded for recycling ...
Yongheng Liang
exaly +2 more sources
ESCRT-mediated phagophore sealing during mitophagy
Autophagy, 2019 Inactivation of the endosomal sorting complex required for transport (ESCRT) machinery has been reported to cause autophagic defects, but the exact functions of ESCRT proteins in macroautophagy/autophagy remain incompletely understood.
Y. Zhen +12 more
semanticscholar +3 more sources
FEBS Letters, 2023 Macroautophagy, hereafter referred to as autophagy, is a complex process in which multiple membrane‐remodeling events lead to the formation of a cisterna known as the phagophore, which then expands and closes into a double‐membrane vesicle termed the ...
C. Kraft, F. Reggiori
semanticscholar +2 more sources
Autophagy, 2021 Macroautophagy/autophagy is an intracellular degradation process that delivers cytosolic materials and/or damaged organelles to lysosomes. De novo synthesis of the autophagosome membrane occurs within a phosphatidylinositol-3-phosphate-rich region of the
Kenichiro Imai +2 more
exaly +2 more sources
ATG16L1 induces the formation of phagophore-like membrane cups
Nature Structural & Molecular BiologyThe hallmark of non-selective autophagy is the formation of cup-shaped phagophores that capture bulk cytoplasm. The process is accompanied by the conjugation of LC3B to phagophores by an E3 ligase complex comprising ATG12–ATG5 and ATG16L1.
Jagan Mohan +10 more
semanticscholar +2 more sources
Phagophore formation by the autophagy conjugation machinery
, 2022 Autophagy is a fundamental cellular recycling pathway that captures cytoplasmic material by a phagophore membrane and delivers it to lysosomes for degradation.
J. Mohan +6 more
semanticscholar +2 more sources
Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore
Autophagy, 2020 Coupling of Atg8 to phosphatidylethanolamine is crucial for the expansion of the crescent-shaped phagophore during cargo engulfment. Atg21, a PtdIns3P-binding beta-propeller protein, scaffolds Atg8 and its E3-like complex Atg12–Atg5-Atg16 during ...
Lena Munzel +10 more
semanticscholar +2 more sources
Scaffolding the cup-shaped double membrane in autophagy.
PLoS Computational Biology, 2017 Autophagy is a physiological process for the recycling and degradation of cellular materials. Forming the autophagosome from the phagophore, a cup-shaped double-membrane vesicle, is a critical step in autophagy.
Amir Houshang Bahrami +4 more
doaj +2 more sources
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure
Nature Communications, 2018 During autophagy, phagophores elongate to form double-membrane vesicles but the mechanism behind their closure is unknown. Here, the authors develop an autophagy assay and find a role for the endosomal sorting complexes required for transport component ...
Yoshinori Takahashi +14 more
doaj +2 more sources
Cell, 2019 Autophagy is a conserved catabolic homeostasis process central for cellular and organismal health. During autophagy, small single-membrane phagophores rapidly expand into large double-membrane autophagosomes to encapsulate diverse cargoes for degradation.
Maximilian Schütter +3 more
semanticscholar +2 more sources