Results 31 to 40 of about 13,993 (208)
The lipid flippase Drs2 regulates anterograde transport of Atg9 during autophagy
Autophagy Reports, 2022 Macroautophagy/autophagy is a conserved catabolic pathway during which cellular material is sequestered within newly formed double-membrane vesicles called autophagosomes and delivered to the lytic compartment of eukaryotic cells for degradation ...
Franziska Kriegenburg +7 more
doaj +1 more source
AMPK Regulates Phagophore-to-Autophagosome Maturation
, 2023 AbstractAutophagy is an important metabolic pathway that can non-selectively recycle cellular material or lead to targeted degradation of protein aggregates or damaged organelles. Autophagosome formation starts with autophagy factors accumulating on lipid vesicles containing ATG9.
Carlo Barnaba +3 more
openaire +2 more sources
Dynamin-2 controls phagophore maturation [PDF]
, 2018 AbstractAutophagy involves rapid growth of phagophores through membrane addition. Newly added membranes are derived from other organelles through vesicles carrying the Atg9 protein. Membrane is delivered by fusing these vesicles with the phagophores. Atg9 is, nevertheless, not incorporated in autophagosomes.
Riera, Alejandro Martorell +6 more
openaire +1 more source
Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore [PDF]
Science Advances, 2023 AbstractThe covalent attachment of ubiquitin-like LC3 proteins prepares the autophagic membrane for cargo recruitment. We resolve key steps in LC3 lipidation by combining molecular dynamics simulations and experimentsin vitroandin cellulo. We show how the E3-like ligase ATG12– ATG5-ATG16L1 in complex with the E2-like conjugase ATG3 docks LC3 onto the ...
Shanlin Rao +6 more
openaire +4 more sources
The autophagic membrane tether ATG2A transfers lipids between membranes
eLife, 2019 An enigmatic step in de novo formation of the autophagosome membrane compartment is the expansion of the precursor membrane phagophore, which requires the acquisition of lipids to serve as building blocks.
Shintaro Maeda +2 more
doaj +1 more source
The aberrant expression of the mesenchymal variant of FGFR2 in the epithelial context inhibits autophagy [PDF]
, 2019 Signaling of the epithelial splice variant of fibroblast growth factor receptor 2 (FGFR2b) triggers both differentiation and autophagy, while the aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induces impaired differentiation ...
Belleudi, Francesca +4 more
core +1 more source
The role of selenium on autophagy
JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2022 Selenium (Se) deficiency is associated with certain abnormalities, such as Keshan disease, cancer, cardiovascular disease (CVD), viral infections, infertility, immune system abnormalities, metabolic diseases, neurological disorders, and growth ...
Febriana Kurniasari +5 more
doaj +1 more source
Autophagy and rheumatoid arthritis: Current knowledges and future perspectives [PDF]
, 2018 Autophagy is a degradation mechanism by which cells recycle cytoplasmic components to generate energy. By influencing lymphocyte development, survival, and proliferation, autophagy regulates the immune responses against self and non-self antigens ...
Alessandri, Cristiano +10 more
core +2 more sources
Mammalian phagophores with finger-like shapes emerge from recycling endosomes
Autophagy, 2023 Autophagosomes are double-membraned vesicles that engulf cytoplasmic contents, which are ultimately degraded after autophagosome-lysosome fusion. The prevailing view, largely inferred from EM-based studies, was that mammalian autophagosomes evolved from disc-shaped precursors that invaginated and then were closed at the single opening.
Claudia Puri, David C Rubinsztein
openaire +2 more sources
The essential role of mitochondrial dynamics in antiviral immunity. [PDF]
, 2018 Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun +3 more
core +2 more sources