Results 31 to 40 of about 11,851 (177)
Communicative and Integrative Biology, 2018 Autophagy is an essential physiological process that maintains cellular homeostasis by eliminating harmful protein aggregates, damaged organelles and certain pathogens through lysosomal degradation.
Shivranjani Moharir, Ghanshyam Swarup
exaly +2 more sources
Journal of Fungi, 2023 Endocytosis and autophagy are the main pathways to deliver cargoes in vesicles and autophagosomes, respectively, to vacuoles/lysosomes in eukaryotes. Multiple positive regulators but few negative ones are reported to regulate the entry of vesicles and ...
Xiaofan Chen, Yongheng Liang
doaj +1 more source
Membrane Contact Sites in Autophagy
Cells, 2022 Eukaryotes utilize different communication strategies to coordinate processes between different cellular compartments either indirectly, through vesicular transport, or directly, via membrane contact sites (MCSs).
Emma Zwilling, Fulvio Reggiori
doaj +1 more source
Cells, 2023 Autophagy–the lysosomal degradation of cytoplasm–plays a central role in cellular homeostasis and protects cells from potentially harmful agents that may accumulate in the cytoplasm, including pathogens, protein aggregates, and dysfunctional organelles ...
Yan Zhen, Harald Stenmark
doaj +1 more source
Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy
eLife, 2021 Autophagy is a cellular process that degrades cytoplasmic cargo by engulfing it in a double-membrane vesicle, known as the autophagosome, and delivering it to the lysosome.
Lisa M Strong +9 more
doaj +1 more source
Autophagy, 2023 Macroautophagy/autophagy is a key catabolic pathway in which double-membrane autophagosomes sequester various substrates destined for degradation, enabling cells to maintain homeostasis and survive under stressful conditions.
Yongook Lee +3 more
semanticscholar +1 more source
The autophagic membrane tether ATG2A transfers lipids between membranes
eLife, 2019 An enigmatic step in de novo formation of the autophagosome membrane compartment is the expansion of the precursor membrane phagophore, which requires the acquisition of lipids to serve as building blocks.
Shintaro Maeda +2 more
doaj +1 more source
The lipid flippase Drs2 regulates anterograde transport of Atg9 during autophagy
Autophagy Reports, 2022 Macroautophagy/autophagy is a conserved catabolic pathway during which cellular material is sequestered within newly formed double-membrane vesicles called autophagosomes and delivered to the lytic compartment of eukaryotic cells for degradation ...
Franziska Kriegenburg +7 more
doaj +1 more source
AMPK Regulates Phagophore-to-Autophagosome Maturation
bioRxiv, 2023 Autophagy is an important metabolic pathway that can non-selectively recycle cellular material or lead to targeted degradation of protein aggregates or damaged organelles.
C. Barnaba +3 more
semanticscholar +1 more source
Mitophagy intermediates in Vps13D depleted neurons engage with a phagophore.
, 2021 A) Representative images of individual larval motoneurons which co-express mitochondrial marker mitoGFP (green) and the indicated RNAi via the D42-Gal4 driver, stained for polyubiquitin (PolyUb, blue), endogenous Atg8A/B (magenta), and endogenous IMM ...
Gábor Juhász (752374) +4 more
core +1 more source