Results 51 to 60 of about 13,993 (208)

LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. [PDF]

, 2019
During autophagy, actin filament networks move and remodel cellular membranes to form autophagosomes that enclose and metabolize cytoplasmic contents. Two actin regulators, WHAMM and JMY, participate in autophagosome formation, but the signals linking ...
Axe, Cooper, Coutts, Coutts, Coyle, Dayel, Demonacos, Firat-Karalar, Graef, Hu, Jahreiss, Kaiser, Kast, Klionsky, Koronakis, Li, Mathiowetz, Mi, Okrut, Padrick, Padrick, Palmgren, Pankiv, Pankiv, Papinski, Quinlan, Quinlan, R. Dyche Mullins, Ran, Rohatgi, Rohatgi, Schlüter, Shibutani, Shikama, Sun, Urbanek, Welch, Xiaohua Hu, Yamamoto, Zhao, Zuchero   +40 more
core   +2 more sources

The phagophore in four dimensions—a study in wood [PDF]

Autophagy, 2018
One of the key features of macroautophagy/autophagy is the dynamic nature of the membrane rearrangements that take place during expansion of the phagophore, the sequestering compartment that matures into an autophagosome. There are various ways to depict this process, but in most cases the method ultimately relies on a two-dimensional medium.
John C. Sewell, Daniel J. Klionsky
openaire   +2 more sources

Myosins, Actin and Autophagy. [PDF]

, 2016
Myosin motor proteins working together with the actin cytoskeleton drive a wide range of cellular processes. In this review, we focus on their roles in autophagy - the pathway the cell uses to ensure homeostasis by targeting pathogens, misfolded proteins
Buss, Folma, Kendrick-Jones, John, Kruppa, Antonina J   +2 more
core   +2 more sources

Defining the membrane precursor supporting the nucleation of the phagophore [PDF]

Autophagy, 2013
How does the phagophore form? Which membrane acts as a platform for its biogenesis? Over the years, extensive use of microscopy techniques have led to the controversial identification of multiple potential membranes as precursors for phagophore nucleation and/or for the supply of lipids to the expanding compartment.
Amélie, Bernard, Daniel J, Klionsky
openaire   +2 more sources

The Rod-Shaped ATG2A-WIPI4 Complex Tethers Membranes In Vitro

Contact, 2018
The autophagosome precursor membrane, termed the isolation membrane or phagophore , emerges adjacent to a phosphatidylinositol 3-phosphate (PI3P)-enriched transient subdomain of the endoplasmic reticulum called the omegasome , thereafter expanding to ...
Takanori Otomo, Saikat Chowdhury, Gabriel C. Lander   +2 more
doaj   +1 more source

The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum. [PDF]

, 2013
Autophagy is a catabolic pathway typically induced by nutrient starvation to recycle amino acids, but can also function in removing damaged organelles. In addition, this pathway plays a key role in eukaryotic development. To date, not much is known about
Bunnik, Evelien M, Cervantes, Serena, Conner, Christopher M, Escalante, Aster, Florens, Laurence, Le Roch, Karine G, Ponts, Nadia, Prudhomme, Jacques, Saraf, Anita, Sardiu, Mihaela E   +9 more
core   +4 more sources

Assays to Monitor Autophagy Progression in Cell Cultures

Cells, 2017
The vast number of implications of autophagy in multiple areas of life sciences and medicine has attracted the interest of numerous scientists that aim to unveil the role of this process in specific physiological and pathological contexts.
Idil Orhon, Fulvio Reggiori
doaj   +1 more source

C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy [PDF]

, 2016
A GGGGCC hexanucleotide repeat expansion in the first intron of the C9orf72 gene is the most common genetic defect associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS/FTD).
De Vos, K., Grierson, A.J., Smith, E.F., Webster, C.P.   +3 more
core   +1 more source

Caspase involvement in autophagy [PDF]

, 2017
Caspases are a family of cysteine proteases widely known as the principal mediators of the apoptotic cell death response, but considerably less so as the contributors to the regulation of pathways outside cellular demise.
A Gross, AB Parrish, AD Rubinstein, AL Anding, AM Abraha, B Zhivotovsky, BD Bell, BT Hyman, C Behrends, C Gaubitz, C He, CA Lamb, CA Mercer, CEL Chua, CH Jung, CH Jung, CL Birmingham, CM Kenific, D Denton, D Denton, D Denton, D Denton, D Narendra, D Oz-Arslan, DC Rubinsztein, DG McEwan, DH Cho, DJ Klionsky, DL Berry, DR McIlwain, E Kuranaga, E Wirawan, E Wong, G Bjørkøy, G Kroemer, G Marino, H Wu, HK Lee, HS Jeong, I Sirois, I Tanida, IG Ganley, Ioannis P Nezis, IP Nezis, IP Nezis, J Diao, J Geng, J Han, J Zhang, J Zirin, JA Pan, JA Seaman, JM Norman, JS Peterson, JS Peterson, K Takeshige, K Zhu, KG Lassen, KK Huynh, KR Parzych, KS Ferreira, L DeVorkin, L Galluzzi, L Lamy, LA Booth, LC Kim, LH Ho, M Djavaheri-Mergny, M Miura, M Tiwari, M Tiwari, M Ulgherait, M You, Ma Laussmann, MA Lynch-Day, ML Würstle, MM Young, N Mizushima, N Mizushima, N Mizushima, N Mizushima, NC Mulakkal, O Oral, P Nilsson, Panagiotis Tsapras, Q Sun, R Kang, R Mathew, R Nunez, R Zoncu, RSY Wong, S Alers, S Bortnik, S Huang, S Kaushik, S Pankiv, S Shalini, S Tu, SL Fink, T Hara, T Johansen, T Lamark, T Shpilka, V Deretic, V Pagliarini, VMS Betin, VMS Betin, W He, W Hou, WW Li, Y Ichimura, Y Zhao, Y Zhu, YB Zhang, YCC Hou   +114 more
core   +1 more source

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major [PDF]

, 2012
Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome ...
A Garami, AD Uboldi, AM Silva, B Levine, Benjamin Cull, C Mammucari, C Osman, DC Rubinsztein, DJ Rigden, DJ Rigden, DL Sacks, DR Voelker, DW Hailey, EG Bligh, EL Axe, FF Hsu, GA McQuibban, GH Coombs, Graham H. Coombs, H Nakatogawa, H Weidberg, I Kim, I Tanida, JC Mottram, Jeremy C. Mottram, K Okamoto, K Wang, K Zhang, K Zhang, Kent L. Hill, LM Stephenson, M Graef, M Herman, N Mendl, P Codogno, PJ Myler, PW Denny, R Scherz-Shouval, R t'Kindt, R t'Kindt, R Zufferey, R Zunino, RA Gottlieb, RA Williams, RA Williams, RA Williams, RA Williams, RL Schweers, Roderick A. M. Williams, S Besteiro, S Pankiv, SA Tooze, T Hanada, T Kanki, T Shintani, Terry K. Smith, U Nair, V Soubannier, W Dowhan, Y Fujioka, Y Zhang, Z Yang   +61 more
core   +8 more sources