Results 11 to 20 of about 11,851 (177)

How Membrane Contact Sites Shape the Phagophore

Contact, 2023
During macroautophagy, phagophores establish multiple membrane contact sites (MCSs) with other organelles that are pivotal for proper phagophore assembly and growth. In S.
Cristina Capitanio, Anna Bieber, Florian Wilfling   +2 more
doaj   +3 more sources

Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure

Communications Biology
VPS37A, an ESCRT-I complex component, is required for recruiting a subset of ESCRT proteins to the phagophore for autophagosome closure. However, the mechanism by which VPS37A is targeted to the phagophore remains obscure.
Yansheng Ye, Xinwen Liang, Guifang Wang, Maria C. Bewley, Kouta Hamamoto, Xiaoming Liu, John M. Flanagan, Hong-Gang Wang, Yoshinori Takahashi, Fang Tian   +9 more
doaj   +3 more sources

The yeast dynamin-like GTPase Vps1 mediates Atg9 transport to the phagophore assembly site in Saccharomyces cerevisiae

Autophagy Reports, 2023
Macroautophagy/autophagy is a degradative pathway that plays an important role in maintaining cellular homeostasis in eukaryotes. During autophagy, cisternal compartments called phagophores are generated to sequester intracellular components; these ...
Yan Hu, Fulvio Reggiori
doaj   +3 more sources

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy [PDF]

Advanced Science
Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
doaj   +3 more sources

Hepatitis C Virus NS5A Activates Mitophagy Through Cargo Receptor and Phagophore Formation

Pathogens
Chronic HCV infection is a risk factor for end-stage liver disease, leading to a major burden on public health. Mitophagy is a specific form of selective autophagy that eliminates mitochondria to maintain mitochondrial integrity.
Yuan-Chao Hsiao, Chih-Wei Chang, Chau-Ting Yeh, Po-Yuan Ke   +3 more
doaj   +3 more sources

Atg9 interactions via its transmembrane domains are required for phagophore expansion during autophagy [PDF]

Autophagy, 2022
During macroautophagy/autophagy, precursor cisterna known as phagophores expand and sequester portions of the cytoplasm and/or organelles, and subsequently close resulting in double-membrane transport vesicles called autophagosomes.
Sabrina Chumpen Ramirez, R. Gómez-Sánchez, Pauline Verlhac, Ralph Hardenberg, E. Margheritis, Katia Cosentino, F. Reggiori, C. Ungermann   +7 more
semanticscholar   +3 more sources

<i>Kenny</i> mediates the recruitment of the phagophore for ubiquitin-dependent mitophagy in <i>Drosophila</i> neurons. [PDF]

Mol Biol Cell
The maintenance of healthy mitochondria is essential to neuronal homeostasis. Mitophagy is a critical mechanism that degrades damaged mitochondria, and disruption of this process is associated with neurodegenerative disease.
Acheampong HO, Rozich E, Haupt Z, Tokarz C, Khan M, Ghosn ZA, Insolera R.   +6 more
europepmc   +2 more sources

A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation [PDF]

Nature Communications
Autophagy degrades cellular material by sequestering it within autophagosomes, which form de novo from precursors called phagophores. Phagophore assembly and expansion require ATG9A-positive seed compartments, the lipid transfer protein ATG2A, and the ...
Elisabeth Holzer, Justyna Sawa-Makarska, Daniel Bernklau, Julia Romanov, Martina Schuschnig, Sascha Martens   +5 more
doaj   +2 more sources

Establishment of the phagophore-ERES membrane contact site initiates phagophore elongation. [PDF]

Nat Struct Mol Biol
The de novo generation of membrane contact sites (MCSs) between the phagophore and the endoplasmic reticulum exit sites (ERES) is important for the acquisition of the lipids necessary for phagophore elongation and autophagosome formation during autophagy.
Gómez-Sánchez R, Chumpen Ramirez S, Vargas Duarte P, Hu Y, Mari M, Olschewski K, Hardenberg R, Fromme JC, Ungermann C, Reggiori F.   +9 more
europepmc   +2 more sources

ER-driven Contact Sites in Autophagosome Biogenesis Sequence [PDF]

Contact
Autophagosome biogenesis is a highly coordinated membrane remodeling process that relies on the de novo formation and expansion of the phagophore, yet the cellular principles governing its spatial and temporal organization remain incompletely understood.
Juliane Da Graça, Dobrawa Amiri Czajkowski, Etienne Morel   +2 more
doaj   +2 more sources