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The Organization and Function of the Phagophore-ER Membrane Contact Sites
Contact (Thousand Oaks (Ventura County, Calif )), 2023 Macroautophagy is characterized by the de novo formation of double-membrane vesicles termed autophagosomes. The precursor structure of autophagosomes is a membrane cistern called phagophore, which elongates through a massive acquisition of lipids until ...
Fulvio Reggiori
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Morphology of Phagophore Precursors by Correlative Light-Electron Microscopy
Cells, 2022 Autophagosome biogenesis occurs in the transient subdomains of the endoplasmic reticulum that are called omegasomes, which, in fluorescence microscopy, appear as small puncta, which then grow in diameter and finally shrink and disappear once the ...
Sigurdur Runar Gudmundsson +2 more
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Endosome-phagophore linking assemblies for the degradation of membrane/extracellular proteins [PDF]
Nature CommunicationsLysosome-targeting chimeras specifically degrade membrane/extracellular proteins with the specificity and potency highly dependent on the expression pattern and kinetics of lysosome-targeting receptors.
Pan Wang +9 more
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ER-endosome contacts generate a local environment promoting phagophore formation
Cell ReportsSummary: Autophagy starts with the formation of a double-membrane vacuole called the autophagosome, initiated by a transient structure known as the phagophore. Previous studies reported that phagophore biogenesis primarily occurs at endoplasmic reticulum
Etienne Morel +2 more
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Kenny is the adaptor protein for ubiquitin-dependent mitophagy in Drosophila melanogaster [PDF]
Autophagy ReportsMitophagy is the selective degradation program for damaged and unnecessary mitochondria to maintain cellular mitostasis and survival. Specific mutations in the mediators for the canonical ubiquitin (ub)-dependent mitophagy pathway have been identified ...
Hubert Osei Acheampong, Ryan Insolera
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TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion
Cell Reports, 2019 Summary: During autophagy, phagophores grow into double-membrane vesicles called autophagosomes, but the underlying mechanism remains unclear. Here, we show a critical role of Atg2A in phagophore expansion.
Tatsuya Hattori +2 more
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ER-driven Contact Sites in Autophagosome Biogenesis Sequence [PDF]
ContactAutophagosome biogenesis is a highly coordinated membrane remodeling process that relies on the de novo formation and expansion of the phagophore, yet the cellular principles governing its spatial and temporal organization remain incompletely understood.
Juliane Da Graça +2 more
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Atg18 interaction positions Atg2 for efficient lipid transfer into phagophore elongation [PDF]
The EMBO JournalDuring macroautophagy, the de novo formation of the autophagosome at a membrane contact site (MCS) with the endoplasmic reticulum requires directional lipid flux for the growth of the initial phagophore before its sealing into an autophagosome and ...
Sabrina Chumpen Ramirez +10 more
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ATG9A-dependent, LC3-independent autophagy curbs the immune system to protect against disease [PDF]
Autophagy ReportsSelective autophagy is generally believed to require the conjugation of microtubule associated protein 1 light chain 3 (LC3) proteins (or other autophagy-related 8 [ATG8] family members) on the inner phagophore leaflet to enable the recruitment of cargo ...
Dario Priem, Mathieu JM Bertrand
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Communicative and Integrative Biology, 2018 Autophagy is an essential physiological process that maintains cellular homeostasis by eliminating harmful protein aggregates, damaged organelles and certain pathogens through lysosomal degradation.
Shivranjani Moharir, Ghanshyam Swarup
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