Polymorphism of Carbamazepine Pharmaceutical Cocrystal: Structural Analysis and Solubility Performance [PDF]
Pharmaceutics, 2023 Polymorphism is a common phenomenon among single- and multicomponent molecular crystals that has a significant impact on the contemporary drug development process. A new polymorphic form of the drug carbamazepine (CBZ) cocrystal with methylparaben (MePRB)
Artem O. Surov +6 more
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Pharmaceutical cocrystal of antibiotic drugs: A comprehensive review [PDF]
Heliyon, 2022 Pharmaceutical cocrystals, which contain at least one active pharmaceutical ingredient (API), are still an attention-grabbing field for researchers. Two or more discrete molecules unite together by non-covalent bonds, e.g., hydrogen, Van der Waals, and π⋯
Mais Bashimam, Hind El-Zein
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Ketoconazole-Fumaric Acid Pharmaceutical Cocrystal: From Formulation Design for Bioavailability Improvement to Biocompatibility Testing and Antifungal Efficacy Evaluation. [PDF]
Int J Mol SciDevelopment of cocrystals through crystal engineering is a viable strategy to formulate poorly water-soluble active pharmaceutical ingredients as stable crystalline solid forms with enhanced bioavailability.
Baldea I +11 more
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Pharmaceutical Cocrystal Formation of Pyrazinamide with 3-Hydroxybenzoic Acid: A Terahertz and Raman Vibrational Spectroscopies Study [PDF]
Molecules, 2019 Vibrational modes of pyrazinamide (PZA), 3-hydroxybenzoic acid (3-hBA), and their cocrystal were characterized using terahertz time-domain (THz-TDS) and Raman vibrational spectroscopic techniques.
Qiqi Wang, Jiadan Xue, Zhi Hong, Yong Du
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Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution.
Prabhakar Panzade +3 more
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Optimisation of Pharmaceutical Cocrystal Dissolution Performance through a Synergistic Precipitation Inhibition. [PDF]
Pharm Res, 2023 Objectives Polymeric excipients play an important role in a cocrystal formulation to act as precipitation inhibitors to maximize the potential. Otherwise, a stable form of the parent drug will be recrystallized on the dissolving cocrystal surface and/or ...
Shi K, Li M.
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Imaging supermolecular interactions of the pharmaceutical-cocrystal of apigenin-nicotinamide binding with serum albumin. [PDF]
Turk J Chem, 2023 In this paper, a new pharmaceutical cocrystal was synthesized using apigenin (AP) and pharmaceutically acceptable conformer nicotinamide (Nico), and the drug delivery between AP-Nico pharmaceutical cocrystal and human serum albumin (HSA) in vivo was ...
Sun Y, Guo M, Zhao X, Wu R.
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Effects of polyvinylpyrrolidone and poly (ethylene glycol) on preparation of ibuprofen pharmaceutical cocrystal [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2023 In this study, we investigated the effects of polymers on the pharmaceutical cocrystal formation process. Ibuprofen (IBU) was selected as the active pharmaceutical ingredient (API), nicotinamide (NIC) and saccharin (SAC) as the cocrystal coformer (CCF ...
Xintong Yang, Yang Chen, Ning Qiao
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Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023 Cocrystallization is an emerging approach for improving physico-chemical characteristics of an active pharmaceutical ingredient (API) for instance dissolution rate, solubility, stability in addition to mechanical properties without affecting their ...
Ameera A Radhi +3 more
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Pharmaceutical Cocrystal Development of TAK-020 with Enhanced Oral Absorption
Crystals, 2020 The objective of this study was to improve the solubility of poorly water-soluble drugs by pharmaceutical cocrystal engineering techniques and select the best pharmaceutical forms with high solubility and solubilized formulations for progress from the ...
Kouya Kimoto +6 more
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