Pharmaceutical Cocrystals—A Review [PDF]
Proceedings, 2021 The design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offers a tremendous opportunity for the development of new drug products with superior physical and ...
Sheetal S. Buddhadev, Kevin C. Garala
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Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications [PDF]
Crystal Growth & Design, 2018 Originally discovered almost a century ago, cocrystals continue to gain interest in the modern day due to their ability to modify the physical properties of solid-state materials, particularly pharmaceuticals.
Maryam Karimi-Jafari +3 more
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Predicting the Solubility of Pharmaceutical Cocrystals in Solvent/Anti-Solvent Mixtures [PDF]
Molecules, 2016 In this work, the solubilities of pharmaceutical cocrystals in solvent/anti-solvent systems were predicted using PC-SAFT in order to increase the efficiency of cocrystal formation processes.
Linda Lange +2 more
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Enhancing the Solubility of Indomethacin: A Breakthrough with Cocrystal Formation [PDF]
PharmaceuticalsBackground/objectives: Pharmaceutical cocrystals have emerged as a promising strategy to enhance the solubility and bioavailability of poorly water-soluble drugs.
Hugo Pardo +3 more
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Crystal engineering optimizes emodin-tetramethylpyrazine combination: From cocrystal design to in vivo anti-colitis efficacy assessment [PDF]
International Journal of Pharmaceutics: XEmodin (EMO) shows therapeutic promise for ulcerative colitis (UC), yet its clinical utility is hampered by low bioavailability. To rationally overcome this limitation, this study employed cocrystal engineering, strategically selecting ...
Meiru Liu +12 more
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Urea as a Cocrystal Former—Study of 3 Urea Based Pharmaceutical Cocrystals [PDF]
Pharmaceutics, 2021 Cocrystallization is commonly used for its ability to improve the physical properties of APIs, such as solubility, bioavailability, compressibility, etc.
Fucheng Leng, Koen Robeyns, Tom Leyssens
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Structural Characterization of Pharmaceutical Cocrystals with the Use of Laboratory X-ray Powder Diffraction Patterns [PDF]
Crystals, 2023 X-ray powder diffraction is a vital analytical tool that is used in pharmaceutical science. It is increasingly used to establish the crystal structure of a new pharmaceutical substance, in particular, cocrystal or its polymorphic forms.
Vladimir V. Chernyshev
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DEVELOPMENT OF COSMETIC CREAM CONTAINING A PHARMACEUTICAL COCRYSTAL OF SALICYLIC AND PHENYLALANINE
International Journal of Applied Pharmaceutics, 2019 Objective: The objective of this present work was to develop the chemical peeling cream containing the synthesized active ingredient pharmaceutical cocrystal of salicylic acid and phenylalanine.
H. Phetmung, Somchai Sawatdee
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ACS OmegaTo improve the water solubility of phloretin, we synthesized the Phl–4B cocrystal using the solvent evaporation method. Various analytical techniques including powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), differential scanning ...
Zhongyu Lu +5 more
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Salt Cocrystallization—A Method to Improve Solubility and Bioavailability of Dihydromyricetin [PDF]
PharmaceuticsObjectives: This study aimed to find salts with similar pharmacological effects designed as cocrystals to improve the aqueous solubility and bioavailability of dihydromyricetin (DMY).
Jingping Li +3 more
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