Results 71 to 80 of about 666,519 (246)

Resolution of a Chiral β‐Aminoketone via Diastereomeric Salt Formation: From Experimental Evidence to Molecular‐Level Insights Into Solution‐Phase Clusters

Chirality, Volume 38, Issue 3, March 2026.
Subtle but significant differences between the heterochiral and homochiral salts during the prenucleation stage, revealed by molecular simulations, are related to the enantiomeric separation of a β‐aminoketone through the precipitation of its corresponding diastereomeric salts. ABSTRACT The classical diastereomeric salt resolution approach was employed
Caterina Momoli, Laura Palombi, Isabella Daidone, Erica Scarel, Massimiliano Aschi   +4 more
wiley   +1 more source

2D Monte Carlo Simulation of Cocrystal Formation Using Patchy Particles

Crystals, 2022
Cocrystals of Active Pharmaceutical Ingredients (APIs) are an attractive therapeutic alternative to salt formations. However, due to the molecular scale processes involved, the earliest stages of cocrystal formation remain poorly understood.
Bogdan Ranguelov, Christo Nanev
doaj   +1 more source

Double Salts and Racemate in Mefloquine–Ibuprofen and Mefloquine–Ketoprofen Systems. A Structural and Thermochemical Analysis

Chirality, Volume 38, Issue 3, March 2026.
(S)‐ibuprofen or ketoprofen were used to resolve mefloquine, forming double salts structurally similar to the racemic forms. ABSTRACT The formation of salts remains a highly sought‐after yet unpredictable strategy for resolving chiral drugs. Using a drug–drug approach, we have investigated the crystallization behavior of Mefloquine (Mf), a racemic ...
Juliana B. Martins, João V. Segatto, Juan C. Tenorio, Paulo S. Carvalho Jr   +3 more
wiley   +1 more source

The crystal packing and slip plane analysis in mechanical properties improvement of mefenamic acid by cocrystallization with nicotinamide coformer

Communications in Science and Technology, 2020
Mefenamic acid is an analgesic non-steroidal anti-inflammatory drug (NSAID) that is categorized as Biopharmaceutical Classification System (BCS) class II drug. Cocrystallization of mefenamic acid (MFA) with nicotinamide (NIC) has been reported to enhance
Ari Wahyudi, Dwi Utami, Arif Budi Setianto   +2 more
doaj   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, Volume 2, Issue 2, Page 184-204, March 2026.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source

Improving the Physicochemical and Biopharmaceutical Properties of Active Pharmaceutical Ingredients Derived from Traditional Chinese Medicine through Cocrystal Engineering [PDF]

, 2021
Danyingzi Guan, Bianfei Xuan, Chengguang Wang, Ruitao Long, Yaqin Jiang, Lina Mao, Jinbing Kang, Ziwen Wang, Shing Fung Chow, Qun Zhou   +9 more
openalex   +1 more source

Direct‐to‐Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Crude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Ariane F. Hübner, Fabian Barthels
wiley   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, Volume 13, Issue 12, 27 February 2026.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Larvicidal Activity of Naringenin: Betaine Cocrystals Against Aedes Aegypti

Crystal Research and Technology, Volume 61, Issue 2, February 2026.
This study demonstrates that naringenin: betaine cocrystals significantly enhance larvicidal activity against Aedes aegypti compared to physical mixtures or pure compounds. Improved dissolution properties contributed to higher mortality rates, supporting the use of cocrystallization as a promising green technology for vector management.
Felipe Zaniol, Patricia Viera de Oliveira, Daniel Albeny‐Simões, Jacir Dal Magro, José Vladimir de Oliveira   +4 more
wiley   +1 more source

Analgesic and Antidiarrheal Properties of Lappaconitine, Possibly Through Cyclooxygenase and µ‐Opioid Receptor Interaction Pathways: In Vivo and In Silico Studies

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Lappaconitine (LAP) is a diterpenoid alkaloid with strong anti‐inflammatory activity. However, there is limited information on its gastroprotective effects. The present study aimed to explore the analgesic and antidiarrheal effects of LAP through in vivo and in silico studies.
Shahid Shah, Arifa Akter, Salehin Sheikh, Razina Rouf, Raihan Chowdhury, Jannatul Ferdous, Md. Shimul Bhuia, Imam Hossain Rakib, Md. Zahid Hasan, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam   +11 more
wiley   +1 more source